The Role of Lck Kinase in T-cell Antigen Receptor Signaling

• Thesis title in Czech: Role kinázy Lck v antigenní signalizaci T-lymfocytů
• Thesis title in English: The Role of Lck Kinase in T-cell Antigen Receptor Signaling
• Key words: Lck, T-lymfocyt, antigen, kináza, enzym
• English key words: Lck, T-cell, antigen, kinase, enzyme
• Academic year of topic announcement: 2019/2020
• Thesis type: Bachelor's thesis
• Thesis language: angličtina
• Department: Department of Genetics and Microbiology (31-140)
• Supervisor: Mgr. Ondřej Štěpánek, Ph.D.
• Author: hidden - assigned by the advisor
• Date of registration: 18.11.2019
• Date of assignment: 18.11.2019
• Date of electronic submission: 14.08.2020
• Date of proceeded defence: 03.09.2020
• Opponents: doc. RNDr. Daniel Rösel, Ph.D.

Preliminary scope of work

Uchazeč vytvoří ucelený literární přehled týkající se role Lck kinázy v antigenní stimulaci T-lymfocytů. Důraz bude kladen na následující aspekty: možná adaptorová funkce molekuly Lck, regulace aktivity Lck, význam Lck vázající CD4 nebo CD8 koreceptor.

Preliminary scope of work in English

The student will carry out a comprehensive literature review focusing on the role of Lck kinase in the antigenic stimulation of T cells. The following aspects will be empasized: the possible adaptor role of Lck, the regulation of Lck activity and the function of Lck interacting with CD4 or CD8 coreceptors.