Aktivita nových akridinových barviv - in vitro studie
| Thesis title in Czech: | Aktivita nových akridinových barviv - in vitro studie |
|---|---|
| Thesis title in English: | Activity of novel acridine dyes - in vitro study |
| Academic year of topic announcement: | 2019/2020 |
| Thesis type: | diploma thesis |
| Thesis language: | čeština |
| Department: | Department of Biochemical Sciences (16-16160) |
| Supervisor: | RNDr. Miloslav Macháček, Ph.D. |
| Author: | hidden - assigned by the advisor |
| Date of registration: | 21.10.2019 |
| Date of assignment: | 19.10.2020 |
| Date and time of defence: | 03.06.2021 09:00 |
| Date of electronic submission: | 14.05.2021 |
| Date of proceeded defence: | 03.06.2021 |
| Opponents: | RNDr. Bc. Eva Novotná, Ph.D. |
| Advisors: | PharmDr. Filip Kostelanský, Ph.D. |
| Mgr. Jan Kubeš | |
| Guidelines |
| 1. Seznámení se s odbornou literaturou a vypracování rešerše. 2. Nácvik potřebných metodik (základy aseptické práce s buněčnými kulturami, cytotoxicitní experimenty apod.) 3. Samostatná experimentální práce. 4. Zpracování a hodnocení dat. 5. Sepsání diplomové práce |
| References |
| Lisa M. Oppegard, Andrei V. Ougolkov, Doris N. Luchini, Renee A. Schoon, John R. Goodell Harneet Kaur, Daniel D. Billadeau, David M. Ferguson, Hiroshi Hiasa. Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II. Eur J Pharmacol. 2009; 602(2-3): 223–229. doi:10.1016/j.ejphar.2008.11.044 John R. Goodell, Andrei V. Ougolkov, Hiroshi Hiasa, Harneet Kaur, Rory Remmel, Daniel D. Billadeau, David M. Ferguson. Acridine-Based Agents with Topoisomerase II Activity Inhibit Pancreatic Cancer Cell Proliferation and Induce Apoptosis. J Med Chem. 2008;51(2):179-82. doi: 10.1021/jm701228e Laurence P. G. Wakelm, Graham J. Atwell, Gordon W. Rewcastle, William A. Denny. Relationships between DNA-Binding Kinetics and Biological Activity for the 9-Aminoacridine-4-carboxamide Class of Antitumor Agents. J. Med. Chem. 1987, 30, 855-861 William A. Denny, Graham J. Atwell, Gordon W. Rewcastle, Bruce C. Baguley. Potential Antitumor Agents. 49. 5-Substituted Derivatives of N-[2-(Dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in Vivo Solid-Tumor Activity. Journal of Medicinal Chemistry, 1987, Vol. 3, No. 4; 658-663 Gordon W. Rewcastle, Graham J. Atwell, David Chambers, Bruce C. Baguley, William A. Denny. Potential Antitumor Agents. 46. Structure-Activity Relationships for Acridine Monosubstituted Derivatives of the Antitumor Agent N-[2-Dimethylamino)ethyl]-9-aminoacridine-4-carboxamide. Journal of Medicinal Chemistry, 1986, Vol. 29, No. 4; 472-477 Graham J. Atwell, Bruce F. Cain,7 Bruce C. Baguley, Graeme J. Finlay, and William A. Denny. Potential Antitumor Agents. 43. Synthesis and Biological Activity of Dibasic 9-Aminoacridine-4-carboxamides, a New Class of Antitumor Agent. J. Med. Chem. 1984, 27, 1481-1485 |