2-(Fosfonomethoxy)ethyl deriváty 6-fluor-3-hydroxypyrazin-2-karboxamidu
| Thesis title in Czech: | 2-(Fosfonomethoxy)ethyl deriváty 6-fluor-3-hydroxypyrazin-2-karboxamidu |
|---|---|
| Thesis title in English: | 2-(Phosphonomethoxy)ethyl derivatives of 6-fluoro-3-hydroxypyrazine-2-carboxamide |
| Key words: | fosfonáty; analogy acyklických nukleosidů; T705; antivirální aktivita |
| English key words: | phosphonates; acyclic nucleoside analogs; T705; antiviral activity |
| Academic year of topic announcement: | 2018/2019 |
| Thesis type: | Bachelor's thesis |
| Thesis language: | čeština |
| Department: | Department of Organic Chemistry (31-270) |
| Supervisor: | doc. RNDr. Jindřich Jindřich, CSc. |
| Author: | hidden - assigned by the advisor, waiting for guarantor's approval |
| Date of registration: | 22.11.2018 |
| Date of assignment: | 08.01.2019 |
| Date of electronic submission: | 16.05.2019 |
| Date of proceeded defence: | 04.06.2019 |
| Opponents: | Ing. Ondřej Baszczyňski, Ph.D. |
| Preliminary scope of work |
| Náplní práce je syntéza 2-(fosfonomethoxy)ethyl derivátů analoga nukleobáze - 6-fluor-3-hydroxypyrazin-2-karboxamidu (T-705) Od tohoto analoga fosfonátů acyklických nukleosidů budou dále připraveny mono a difosfáty a také odpovídající proléčiva. Takto připravené látky budou testovány na antivirální aktivitu na spolupracujícím pracovišti v Belgii. |
| Preliminary scope of work in English |
| The work will deal with the synthesis of 2-(phosphonomethoxy)ethyl derivatives of a nucleobase analog - 6-fluoro-3-hydroxypyrazine-2-carboxamide (T-705). From this acyclic nucleoside phosphonate analog, mono and diphosphates and the corresponding prodrugs will be further prepared. The synthesized compounds will be tested for their antiviral activity at the collaborators' facility in Belgium. |