Syntéza analogů nukleosidů založených na derivátech 2-deoxy-2-fluor- a 3-deoxy-3-fluor-D-ribosy a pyrazinu

• Thesis title in Czech: Syntéza analogů nukleosidů založených na derivátech 2-deoxy-2-fluor- a 3-deoxy-3-fluor-D-ribosy a pyrazinu
• Thesis title in English: Synthesis of nucleoside analogs based on derivatives of 2-deoxy-2-fluoro- and 3-deoxy-3-fluoro-D-ribose and pyrazines
• Key words: favipiravir (T-705), T-1105, proléčiva, fosfonáty, fluorované nukleosidy
• English key words: favipiravir (T-705), T-1105, prodrugs, phosphonates, fluorinated nucleosides
• Academic year of topic announcement: 2018/2019
• Thesis type: diploma thesis
• Thesis language: čeština
• Department: Department of Organic Chemistry (31-270)
• Supervisor: doc. RNDr. Jindřich Jindřich, CSc.
• Author: hidden - assigned by the advisor
• Date of registration: 12.10.2018
• Date of assignment: 09.01.2019
• Date of electronic submission: 13.08.2020
• Date of proceeded defence: 16.09.2020
• Opponents: doc. Ing. Stanislav Smrček, CSc.

Guidelines

Sacharidy
Alkaloidy
Supramolekulární chemie

Preliminary scope of work

Náplní práce bude syntéza 2-deoxy-2-fluor-ribosových prekursorů vhodných pro N-glykosylační reakci s hetarylovými deriváty 3-hydroxypyrazin-2-karboxamidu a příprava pro-drugs vhodných pro testování antivirální aktivity.

Preliminary scope of work in English

The work will deal with the synthesis of 2-deoxy-2-fluoro-ribosyl precursors suitable for N-glycosylation reaction with hetaryl derivatives based on 3-hydroxypyrazine-2-carboxamide and preparation of pro-drugs suitable for testing of antiviral activity.