Thesis (Selection of subject)

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Synthesis of N-(per)fluoroalkyl azoles by rhodium(II)-catalyzed transannulation of N-(per)fluoroalkyl-1,2,3-triazoles

Thesis title in Czech:	Syntéza N-(per)fluoralkyl azolů rhodium(II) katalyzovanou transanulací N-(per)fluoralkyl-1,2,3-triazolů
Thesis title in English:	Synthesis of N-(per)fluoroalkyl azoles by rhodium(II)-catalyzed transannulation of N-(per)fluoroalkyl-1,2,3-triazoles
Key words:	azid; fluor; triazol; pyrrol; indol
English key words:	azide; fluorine; triazole; pyrrole; indole
Academic year of topic announcement:	2018/2019
Thesis type:	dissertation
Thesis language:	angličtina
Department:	Department of Organic Chemistry (31-270)
Supervisor:	Ing. Petr Beier, Ph.D.
Author:	hidden - assigned by the advisor
Date of registration:	08.10.2018
Date of assignment:	08.10.2018
Date of electronic submission:	22.12.2023
Date of proceeded defence:	20.03.2024
Opponents:	prof. Ing. Pavel Kočovský
	prof. doc. Ing. Jaroslav Kvíčala, CSc.

References

1. Z. E. Blastik, P. Beier, et al. Angew. Chem. Int. Ed. 2017, 56, 346.
2. A. Budinská, P. Beier, et al. Org. Lett. 2016, 18, 5844.
3. S. Voltrová, P. Beier, et al. Org. Biomol. Chem. 2017, 15, 4962.

Preliminary scope of work

Naše nedávno publikovaná syntéza perfluoralkyl azidů otevřela nové možnosti ke studiu vlastností a reaktivity těchto látek. V tomto projektu budou studovány nové syntetické přístupy k obecně málo probádaným N-perfluoralkylovaným sloučeninám jako jsou azidy, azoly, močoviny, karbamáty a amidy. Očekává se, že tato skupina látek najde použití ve vývoji nových léčiv a materiálů.

Preliminary scope of work in English

The recently reported synthesis of perfluoroalkyl azides opened the door to study properties and reactivity of these compounds. In this project, the rich chemistry of (per)fluoroalkyl azides will be investigated and new synthetic approaches to underdeveloped N-fluoroalkyl-containing compounds such as azides, azoles, ureas, carbamates, and amides will be studied. This class of compounds is expected to find utilization in drug discovery and in the development of new materials.