Hybridní polymerní-lipidické nanočástice jako nosiče léčiv
| Thesis title in Czech: | Hybridní polymerní-lipidické nanočástice jako nosiče léčiv |
|---|---|
| Thesis title in English: | Hybrid polymeric-lipid nanoparticles as drug carriers |
| Key words: | PLGA, fosfolipid, lipidní-polymerní hybridní nanočástice |
| English key words: | PLGA, fosfolipid, lipid-polymer hybrid nanoparticles |
| Academic year of topic announcement: | 2018/2019 |
| Thesis type: | diploma thesis |
| Thesis language: | čeština |
| Department: | Department of Pharmaceutical Technology (16-16210) |
| Supervisor: | PharmDr. Ondřej Holas, Ph.D. |
| Author: | hidden - assigned by the advisor |
| Date of registration: | 02.10.2018 |
| Date of assignment: | 25.02.2020 |
| Date and time of defence: | 04.06.2020 10:00 |
| Date of electronic submission: | 15.05.2020 |
| Date of proceeded defence: | 04.06.2020 |
| Opponents: | Mgr. Monika Smékalová, Ph.D. |
| Guidelines |
| Po prostudování literatury bude následovat experimentální část zaměřená na přípravu nanočástic jako potenciálních nosičů léčiv. |
| References |
| Hadinotto, K., Sundersan, A., Cheow, W.S. Lipid–polymer hybrid nanoparticles as a new generation therapeutic delivery platform: A review. Eur. J. Pharm. Biopharm. 2013, 85, 427-443 Tammam S.N., Azzazy H.M.E., Lamprecht, A. Biodegradable Particulate Carrier Formulation and Tuning for Targeted Drug Delivery. J. Biomed. Nanotechnol. 2015, 11, 555-577 Hans M.L., Lowman A.M. Biodegradable nanoparticles for drug delivery and targeting, Curr. Opp. Sol. St. Mat. Sci. 2002, 6, 319-327 Hickey J.W., Santos J.L., Williford J.M., Mao H.Q. Control of polymeric nanoparticle size to improve therapeutic delivery, J. Control Release, 2015, 10, 536-547 Rao J.P., Gelecker H.E. Polymer nanoparticles: Preparation techniques and size-control parameters, 2011, 36, 887-913 Bennet D., Kim S. 2014, Polymer nanoparticles for smart drug delivery, Application of Nanotechnology in Drug Delivery, PhD. Ali Demir Sezer (Ed.), InTech, DOI: 10.5772/58422 |
| Preliminary scope of work |
| Příprava hybridních nanočástic s enkpsulovanýcm léčivem Hodnocení enkapsulační efektivity Disoluční testy Sepsání práce |
| Preliminary scope of work in English |
| Preparation of drug loaded nanoparticles Drug release testing Encapsulation efficiency assessment Writing a thesis |