Experimentálne stanovenie fotodynamickej účinnosti derivátov ftalocyanínov a stanovenie bunkovej smrti.

• Thesis title in thesis language (Slovak): Experimentálne stanovenie fotodynamickej účinnosti derivátov ftalocyanínov a stanovenie bunkovej smrti.
• Thesis title in Czech: Experimentální stanovení fotodynamické účinnosti derivátů ftalocyaninů a stanovení buněčné smrti.
• Thesis title in English: Experimental evaluation of photodynamic efficiency of phthalocyanine photosensitisers and cell death assessment.
• Academic year of topic announcement: 2019/2020
• Thesis type: Bachelor's thesis
• Thesis language: slovenština
• Department: Department of Biochemical Sciences (16-16160)
• Supervisor: RNDr. Miloslav Macháček, Ph.D.
• Author: hidden - assigned by the advisor
• Date of registration: 30.10.2019
• Date of assignment: 11.02.2021
• Date and time of defence: 01.06.2021 09:00
• Date of electronic submission: 17.05.2021
• Date of proceeded defence: 01.06.2021
• Opponents: Mgr. Petra Kollárová, Ph.D.
• Advisors: Mgr. Marie Halašková, Ph.D.

Guidelines

Osvojení si zásad práce s odbornou literaturou
Vyhledání a zpracování odpovídající recentní literatury
Vypracování rešerše k teoretické části práce
Experimentální práce
Zpracování výsledků

References

AGOSTINIS, Patrizia, Kristian BERG, Keith A. CENGEL, Thomas H. FOSTER, Albert W. GIROTTI, Sandra O. GOLLNICK, Stephen M. HAHN, Michael R. HAMBLIN, Asta JUZENIENE, David KESSEL, Mladen KORBELIK, Johan MOAN, Pawel MROZ, Dominika NOWIS, Jacques PIETTE, Brian C. WILSON a Jakub GOLAB. Photodynamic therapy of cancer: An update. CA: A Cancer Journal for Clinicians. 2011, vol. 61, issue 4, s. 250-281
MACDONALD, IAN J. a THOMAS J. DOUGHERTY. Basic principles of photodynamic therapy. Journal of Porphyrins and Phthalocyanines. 2001, vol. 05, issue 02, s. 105-129
CASTANO, Ana P., Tatiana N. DEMIDOVA a Michael R. HAMBLIN. Mechanisms in photodynamic therapy: part one—photosensitizers, photochemistry and cellular localization. Photodiagnosis and Photodynamic Therapy. 2004, vol. 1, issue 4, s. 279-293
JOSEFSEN, L B a R W BOYLE. Photodynamic therapy: novel third-generation photosensitizers one step closer?. British Journal of Pharmacology. 2008, vol. 154, issue 1, s. 1-3
MACHACEK Miloslav, Kevin CARTER, Filip KOSTELANSKY, Dyego MIRANDA, A SEFFOUH, J ORTEGA, Tomas SIMUNEK, Petr ZIMCIK, J LOVELL. Binding of an amphiphilic phthalocyanine to pre-formed liposomes confers light-triggered cargo release.
Journal of Materials Chemistry B. 2018; 6: 7298-7305
KOLLAR, Jan, Miloslav MACHACEK, MAarie HALASKOVA, Juraj LENCO, Radim KUCERA, Jiri DEMUTH, Monika STEKLA, Katerina HASONOVA, Miroslav MILETIN, Veronika NOVAKOVA, Petr ZIMCIK. Cationic versus Anionic Phthalocyanines for Photodynamic Therapy: What a Difference the Charge Makes. Journal of Medicinal Chemistry. 2020; 63(14); 7616-7632