On Saturday 19th October 2024 there will be a shutdown of some components of the information system. Especially the work with files in Thesis modules will be particularly unavailable. Please postpone your requests for a later time. |
Detection of Sap2 in the secretome of Candida albicans cell wall and secretory mutants
Thesis title in Czech: | Detekce Sap2 proteinu v sekretomu kmenů Candida albicans mutantních v buněčné stěně a sekreci |
---|---|
Thesis title in English: | Detection of Sap2 in the secretome of Candida albicans cell wall and secretory mutants |
Key words: | Candida albicans; Sap2; sekretom; LC-MS/MS analýza |
English key words: | Candida albicans; Sap2; secretome; LS-MS/MS analysis |
Academic year of topic announcement: | 2017/2018 |
Thesis type: | rigorosum thesis |
Thesis language: | angličtina |
Department: | Department of Biochemical Sciences (16-16160) |
Supervisor: | PharmDr. Ondřej Janďourek, Ph.D. |
Author: | hidden - assigned and confirmed by the Study Dept. |
Date of registration: | 27.09.2017 |
Date of assignment: | 27.09.2017 |
Confirmed by Study dept. on: | 27.09.2017 |
Date and time of defence: | 15.02.2018 00:00 |
Date of electronic submission: | 14.02.2018 |
Date of proceeded defence: | 15.02.2018 |
Opponents: | RNDr. Klára Konečná, Ph.D. |
Advisors: | Gloria Molero, Dr., Ph.D. |
Guidelines |
Rešerše literárních pramenů problematiky Zpracování praktické části diplomové práce a vlastní provedení experimentů Vyhodnocení a diskuze výsledků |
References |
GIL-BONA, Ana; MONTEOLIVA, Lucía; GIL, Concha. Global proteomic profiling of the secretome of Candida albicans ecm33 cell wall mutant reveals the involvement of Ecm33 in Sap2 secretion. Journal of proteome research, 2015, 14.10: 4270-4281. Využití databáze PubMed a další literatury |
Preliminary scope of work |
Cílem této práce je objasnit, zda defekt v sekreci Sap2 proteinu je specifický pro Ecm33 mutanta C. albicans (RML2U) nebo je spojen všeobecně s poškozením buněčné stěny či sekrečních mechanismů. |
Preliminary scope of work in English |
The aim of this work is to elucidate if the defect in Sap2 secretion is specific of C. albicans Ecm33 mutant (RML2U) or is related with general defects in cell wall or secretion pathways. |