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Alkaloidy Zephyranthes citrina (Amaryllidaceae): izolace, strukturní identifikace, biologická aktivita.
| Thesis title in Czech: | Alkaloidy Zephyranthes citrina (Amaryllidaceae): izolace, strukturní identifikace, biologická aktivita. |
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| Thesis title in English: | Alkaloids of Zephyranthes citrina (Amaryllidaceae): isolation, identification, biological activity. |
| Key words: | alkaloidy, izolace, čeleď Amaryllidaceae, biologická aktivita |
| English key words: | alkaloids, isolation, Amaryllidaceae family, biological activity |
| Academic year of topic announcement: | 2017/2018 |
| Thesis type: | dissertation |
| Thesis language: | čeština |
| Department: | Department of Pharmaceutical Botany (16-16130) |
| Supervisor: | prof. Ing. Lucie Cahlíková, Ph.D. |
| Author: | hidden - assigned by the advisor |
| Date of registration: | 02.10.2017 |
| Date of assignment: | 02.10.2017 |
| Date and time of defence: | 15.09.2021 09:30 |
| Date of electronic submission: | 16.07.2021 |
| Date of submission of printed version: | 19.07.2021 |
| Date of proceeded defence: | 15.09.2021 |
| Opponents: | prof. RNDr. Oldřich Lapčík, Ph.D. |
| prof. PharmDr. Pavel Mučaji, Ph.D. | |
| Preliminary scope of work |
| Extraction and isolation of alkaloids from selected plants of family Amaryllidaceae in order to study their biological activity. For the isolation of the alkaloids will be used conventional chromatographic methods such as column chromatography, flash chromatography, preparative thin-layer chromatography, preparative HPLC. Isolated substances will be identified by using of spectroscopic methods and will be subjected to screening for testing their biological activities at the Department of Pharmaceutical Botany (inhibition of AChE, BuChE, POP, GSK-3β) and in cooperation with national and foreign institutions (BACE-1, cytotoxicity, antimicrobial activity, antimalarial activity and others). The active substance will be subjected to more detailed biological tests (e.g. in the case of inhibition cholinestrases will be studied type of inhibition, transfer through BBB, etc.). |