Ddi1-like proteins: a novel family of retroviral-like aspartyl proteases

• Thesis title in Czech: Proteiny Ddi1: nová rodina retrovirům podobných aspartátových proteas
• Thesis title in English: Ddi1-like proteins: a novel family of retroviral-like aspartyl proteases
• Key words: ubikvitin-proteasomový systém, ubikvitin, proteasa, poškození DNA
• English key words: ubiquitin-proteasome pathway, ubiquitin, protease, DNA damage
• Academic year of topic announcement: 2016/2017
• Thesis type: Bachelor's thesis
• Thesis language: angličtina
• Department: Department of Genetics and Microbiology (31-140)
• Supervisor: Mgr. Klára Grantz Šašková, Ph.D.
• Author: hidden - assigned by the advisor, waiting for guarantor's approval
• Date of registration: 14.10.2016
• Date of assignment: 14.10.2016
• Date of electronic submission: 14.05.2017
• Date of proceeded defence: 06.06.2017
• Opponents: RNDr. Michal Šmahel, Ph.D.

Preliminary scope of work

Studentka vypracuje podrobnou rešerši na téma funkční charakterizace jednotlivých členů proteinové rodiny tzv. "DNA damage-inducible proteins 1", neboli Ddi1 proteinů. Zaměří se zejména na Ddi1 z kvasinky Saccharomyces cerevisiae, Ddi1 z červa C. elegans, Ddi1 z octomilky a v neposlední řadě také popíše oba lidské homology tohoto proteinu, Ddi1 a Ddi2.

Preliminary scope of work in English

The student will focus on complete functional characterization (in terms of work with the literature, no experimental work will be included) of several members of proteins from Ddi1-like protein family (DNA damage-inducible proteins 1-like), namely Ddi1 from Saccharamyces cerevisiae, Ddi1 from C. elegans, Ddi1 from drosophila and last but not least both human Ddi1 and Ddi2.