hidden - assigned by the advisor, waiting for guarantor's approval
Date of registration:
04.10.2016
Date of assignment:
11.10.2016
Date of electronic submission:
14.05.2017
Date of proceeded defence:
05.06.2017
Opponents:
doc. RNDr. Magdaléna Krulová, Ph.D.
Preliminary scope of work
The student will review current scientific literature on the topic of homeostatic memory and virtual memory T cells. Homeostatic memory T cells are generated from naive CD8+ Tlymphocytes during lymphopenia. Virtual memory CD8+ T cells also do not represent true immunological memory, because they are generated in the absence of a cognate foreign antigen. In contrast to homeostatic memory T cells, virtual memory T cells naturally occur in healthy lymphoreplete hosts. The origin of virtual memory T cells is still unclear, but they might represent the same T cell subset as experimentally induced homeostatic memory T cells. Gene expression signature and functional characteristics of homeostatic and virtual memory T cells will be compared to resolve whether or not homeostatic memory and virtual memory T cells represent the same differentiation program. Last but not least, the student will compare these T cells populations with conventional „true“ memory T cells that are formed upon exposure to cognate foreign antigens.
Preliminary scope of work in English
The student will review current scientific literature on the topic of homeostatic memory and virtual memory T cells. Homeostatic memory T cells are generated from naive CD8+ T lymphocytes during lymphopenia. Virtual memory CD8+ T cells also do not represent true immunological memory, because they are generated in the absence of a cognate foreign antigen. In contrast to homeostatic memory T cells, virtual memory T cells naturally occur in healthy lymphoreplete hosts. The origin of virtual memory T cells is still unclear, but they might represent the same T cell subset as experimentally induced homeostatic memory T cells. Gene expression signature and functional characteristics of homeostatic and virtual memory T cells will be compared to resolve whether or not homeostatic memory and virtual memory T cells represent the same differentiation program. Last but not least, the student will compare these T cells populations with conventional „true“ memory T cells that are formed upon exposure to cognate foreign antigens.
- assigned by the advisor, waiting for guarantor's approval