Protidestičkové účinky flavonoidů
| Thesis title in Czech: | Protidestičkové účinky flavonoidů |
|---|---|
| Thesis title in English: | Antiplatelet effects of flavonoids |
| Key words: | flavonoid, krevní destičky, agregace |
| English key words: | flavonoid, platelets, aggregation |
| Academic year of topic announcement: | 2015/2016 |
| Thesis type: | diploma thesis |
| Thesis language: | čeština |
| Department: | Department of Pharmacology and Toxicology (16-16170) |
| Supervisor: | prof. PharmDr. Přemysl Mladěnka, Ph.D. |
| Author: | hidden - assigned by the advisor |
| Date of registration: | 16.12.2015 |
| Date of assignment: | 16.12.2015 |
| Date and time of defence: | 31.05.2017 08:00 |
| Date of electronic submission: | 12.05.2017 |
| Date of proceeded defence: | 31.05.2017 |
| Opponents: | PharmDr. Eduard Jirkovský, Ph.D. |
| Guidelines |
| Vyhledání informací v informačních databázích a v odborné literatuře nezbytných k vypracování rešeršní diplomové práce. Sepsání diplomové práce podle "Závazných pokynů pro vypracování diplomových prací" platných na Katedře farmakologie a toxikologie. |
| References |
| Informační databáze – PubMed, Scopus a Web Of Science Mladenka P, Zatloukalová L, Filipský T, Hrdina R. Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity. Free Radic Biol Med. 2010 Sep 15;49(6):963-75. Landolfi R, Mower RL, Steiner M. Modification of platelet function and arachidonic acid metabolism by bioflavonoids. Structure-activity relations. Biochem. Pharmacol. 33:1525–1530; 1984. Hubbard GP, Stevens JM, Cicmil M, Sage T, Jordan PA, Williams CM, Lovegrove JA, Gibbins JM, Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway. J. Thromb. Haemost. 1:1079–1088;2003. Navarro-Nunez L, Castillo J, Lozano, ML, Martinez C, Benavente-Garcia O, Vicente, V, Rivera J. Thromboxane A2 receptor antagonism by flavonoids: structure-activity relationships. J. Agric. Food Chem. 57:1589–1594; 2009. Guerrero JA, Navarro-Nunez L, Lozano ML, Martinez C, Vicente V, Gibbins JM, Rivera J. Flavonoids inhibit the platelet TxA(2) signalling pathway and antagonize TxA(2) receptors (TP) in platelets and smooth muscle cells. Br. J. Clin. Pharmacol. 64:133–144; 2007. Karlíčková J, Říha M, Filipský T, Macáková K, Hrdina R, Mladěnka P. Antiplatelet Effects of Flavonoids Mediated by Inhibition of Arachidonic Acid Based Pathway. Planta Med. 2015 Sep 21. |
| Preliminary scope of work |
| Rešerše na téma protidestičkové účinky flavonoidů |
| Preliminary scope of work in English |
| Review on the topic of antiplatelet effects of flavonoids |