Thesis (Selection of subject)

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Kardioprotektivní úloha adaptací na hypoxii a chlad: Konexin 43 a hexokináza 2

Thesis title in thesis language (Slovak):	Kardioprotektivní úloha adaptací na hypoxii a chlad: Konexin 43 a hexokináza 2
Thesis title in Czech:	Kardioprotektivní úloha adaptací na hypoxii a chlad: Konexín 43 a hexokináza 2
Thesis title in English:	Cardioprotective effect of adaptations to hypoxia and cold: Connexin 43 and hexokinase 2
Key words:	Potkan, Srdce, Chlad, Hypoxia, Konexín 43, Hexokináza
English key words:	Rat, Heart, Cold, Hypoxia, Connexin 43, Hexokinase
Academic year of topic announcement:	2013/2014
Thesis type:	dissertation
Thesis language:	slovenština
Department:	Department of Physiology (31-152)
Supervisor:	doc. RNDr. Jitka Žurmanová, Ph.D.
Author:	hidden - assigned by the advisor
Date of registration:	06.10.2014
Date of assignment:	06.10.2014
Date and time of defence:	27.03.2019 13:00
Date of electronic submission:	27.01.2019
Date of proceeded defence:	27.03.2019
Opponents:	doc. MUDr. Jana Radošinská, Ph.D.
	RNDr. Miroslav Barančík, DrSc.

Preliminary scope of work

Výskyt malígnych arytmií, ako dôsledok ischemicko-reperfúzneho (I/R) poškodenia srdca má významnú úlohu v úmrtnosti v súčasnej populácií, preto poznanie endogénnych ochranných mechanizmov je celospoločensky významné a môže prispieť k zlepšeniu farmakologickej liečby. Cieľom dizertačnej práce bolo lepšie pochopiť význam distribúcie Cx43 a isoforiem hexokinázy a rôznych fosforylácií Cx43 a nájsť ich súvislosť s antiarytmickým účinkom adaptácie na hypoxiu a na chlad.

Preliminary scope of work in English

Malignant arrhythmias as a consequence of ischemia-reperfusion injury in the heart has an important role in mortality in the current population, the knowledge of endogenous protective mechanisms is of great importance and can contribute to the improvement of pharmacological treatment. The aim of the dissertation was to better understand the importance of the distribution of Cx43 and hexokinase and the various Cx43 phosphorylations and to find their connection with the antiarrhythmic effect of adaptation to IHH and cold.