Pharmacological perspectives and clinical benefits of SIRT1 and AMPK activators and inhibitors in inflammatory and oxidative stress in the liver
| Thesis title in Czech: | Perspektivy farmakologického a klinického přínosu aktivátorů a inhibitorů sirtuinu 1 a AMPK při zánětlivém a oxidativním poškození v jaterní tkáni |
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| Thesis title in English: | Pharmacological perspectives and clinical benefits of SIRT1 and AMPK activators and inhibitors in inflammatory and oxidative stress in the liver |
| Key words: | acetaminophen; adenosine monophosphate protein kinase (AMPK); AICAR; CAY10591; Compound C; D-Galactosamine (GalN)/lipopolysaccharide (LPS); enzyme activation; EX-527; hepatocyte protection; hepatotoxicity; sirtuin 1 (SIRT1) |
| English key words: | AICAR; aktivace enzymu; AMP-aktivovaná proteinová kináza (AMPK); CAY10591; Compound C; D-galaktózamin (GalN)/lipopolysacharid (LPS); EX-527; hepatotoxicita; hepatoprotekce; paracetamol; sirtuin 1 (SIRT1) |
| Academic year of topic announcement: | 2013/2014 |
| Thesis type: | dissertation |
| Thesis language: | angličtina |
| Department: | Institute of Pharmacology First Faculty of Medicine Charles University and General University Hospital in Prague (11-00190) |
| Supervisor: | MUDr. Nikolina Canová, Ph.D. |
| Author: | hidden - assigned and confirmed by the Study Dept. |
| Date of registration: | 31.07.2014 |
| Date of assignment: | 31.07.2014 |
| Confirmed by Study dept. on: | 31.07.2014 |
| Date and time of defence: | 01.04.2022 14:30 |
| Venue of defence: | Albertov 4, Praha 2, FARMS7, 3075, Albertov 4, 2. patro, knihovna |
| Date of electronic submission: | 02.02.2022 |
| Date of proceeded defence: | 01.04.2022 |
| Course: | Defence of the dissertation (B90002) |
| Opponents: | prof. RNDr. Petr Hodek, CSc. |
| doc. MUDr. Martin Votava, Ph.D. | |