JNK3 MAP-kinase localization in the brain of mice with Alzheimer’s disease
| Thesis title in Czech: | LOKALIZACE JNK3 MAP-KINÁZY V MOZKU MYŠÍ POSTIŽENÝCH ALZHEIMEROVOU CHOROBOU |
|---|---|
| Thesis title in English: | JNK3 MAP-kinase localization in the brain of mice with Alzheimer’s disease |
| Academic year of topic announcement: | 2013/2014 |
| Thesis type: | diploma thesis |
| Thesis language: | angličtina |
| Department: | Department of Biological and Medical Sciences (16-16150) |
| Supervisor: | PharmDr. Jana Urbánková Rathouská, Ph.D. |
| Author: | hidden - assigned by the advisor |
| Date of registration: | 25.06.2014 |
| Date of assignment: | 25.06.2014 |
| Date and time of defence: | 04.06.2015 00:00 |
| Date of electronic submission: | 28.04.2015 |
| Date of proceeded defence: | 04.06.2015 |
| Opponents: | doc. MUDr. Josef Herink, DrSc. |
| Guidelines |
| 1. Rešerše odborné literatury 2. Imunohistochemická analýza zvoleného markeru - detekce, specifikace lokalizace 3. Zhodnocení 4. Diskuse 5. Závěry |
| References |
| (1) Alzheimer`s Association., 2012. Alzheimer`s disease facts and figure. Alzheimer`s Dement. 8, 131-168 (2) Rubio-Perez and Morillas-Ruiz,2012, A review: inflammatory process in Alzheimer’s disease, role of cytokines. Scientific World Journal 2012, 756357 (3) Yang DD, Kuan CY, Absence of excitotoxicity-induced apoptosis in hippocampus of mice lacking the Jnk3 gene. Nature 1997,389(6653) (4) W.Haeusgen et al., Specific activities of individual c-Jun N-terminal kinases in the brain, Neuroscience 161,2009 951-959 (5) Sung ok Yoon, Dong Ju Park, Jae Cheon Ryu, at al., JNK3 perpetuates metabolic stress induced by Aβ peptides, Neuron 75,824-837,2012 sept. (6) Bogoyevitz M.A., The isoform specific functions of the JNKs : difference revealed by gene targeting,2006 Wiley periodicals, Bio Essays 28,923-934 (7) Brown PH, Alani R, Preis LH, Szabo E, Birrer MJ, Supression of oncogene-induced transformation by delection mutant of c-Jun. Oncogene 1993, 8, 877-866 (8) Hikari Y., Sato H., Hiroto N, JNK regulates the photic response of the mammalian circadian clock, 2012EMbor |
| Preliminary scope of work |
| 1) Rešerše literatury týkající se zadané problematiky 2) Základy imunohistochemického barvení 3) Aplikace metody na sledování exprese JNK3-MAP kinázy v myším mozku 4) Zhodnocení výsledků 5) Diskuse a závěry |
| Preliminary scope of work in English |
| 1) Review of the literature 2) Basics of the immunohistochemical staining 3) Application of the method on JNK3-MAP kinase expression in mouse brain 4) Resuls evaluation 5) Discussion and results |