Individualized pharmacokinetically guided dosage adjustment of fluorouracil using population pharmacokinetic modeling
| Thesis title in Czech: | Individualizovaná farmakokineticky vedená úprava dávkování fluorouracilu s použitím populačního farmakokinetického modelu |
|---|---|
| Thesis title in English: | Individualized pharmacokinetically guided dosage adjustment of fluorouracil using population pharmacokinetic modeling |
| Key words: | fluorouracil, pharmacokinetic, efficacy, tolerability |
| English key words: | fluorouracil, pharmacokinetic, efficacy, tolerability |
| Academic year of topic announcement: | 2013/2014 |
| Thesis type: | diploma thesis |
| Thesis language: | angličtina |
| Department: | Department of Social and Clinical Pharmacy (16-16220) |
| Supervisor: | prof. RNDr. Jiří Vlček, CSc. |
| Author: | hidden - assigned by the advisor |
| Date of registration: | 27.01.2014 |
| Date of assignment: | 27.01.2014 |
| Date and time of defence: | 23.09.2014 08:25 |
| Date of electronic submission: | 03.09.2014 |
| Date of proceeded defence: | 23.09.2014 |
| Opponents: | prof. PharmDr. Petr Pávek, Ph.D. |
| Guidelines |
| 1) Model building with existing data 2) Validation 3) Simulation for limited sampling 4) Development of Excel tool 5) Comparison |
| References |
| 1. Bonate PL. (2011) Pharmacokinetic-Pharmacodynamic Modeling and Simulation. 2nd edition. Springer, New York, pp. 620. 2. Ette EI and Williams PJ. (2007) Pharmacometrics: The Science of Quantitative Pharmacology. John Wiley & Sons, Inc., London, pp. 1216. 3. Mould DR and Upton RN. (2013) Basic concepts in population modeling, simulation, and model-based drug development - Parts 1-2. Pharmacometrics & Systems Pharmacology: 2:e38. |
| Preliminary scope of work |
| To increase the efficacy and tolerability of fluorouracil (5-FU) with pharmacokinetically-guided dose adjustment based on a target-AUC. To develop a user friendly Excel tool to estimate individual AUCs based on a population pharmacokinetic (PK) model for 5-FU. To ensure quality, the AUC estimated with the PK model will be compared to the AUC calculated with a simple equation (AUC(5-FU) = steady-state concentration x infusion duration) in terms of bias and precision. |
| Preliminary scope of work in English |
| To increase the efficacy and tolerability of fluorouracil (5-FU) with pharmacokinetically-guided dose adjustment based on a target-AUC. To develop a user friendly Excel tool to estimate individual AUCs based on a population pharmacokinetic (PK) model for 5-FU. To ensure quality, the AUC estimated with the PK model will be compared to the AUC calculated with a simple equation (AUC(5-FU) = steady-state concentration x infusion duration) in terms of bias and precision. |