Amidoximes as intermediates for the synthesis of potential drugs

• Thesis title in English: Amidoximes as intermediates for the synthesis of potential drugs
• Academic year of topic announcement: 2013/2014
• Thesis type: diploma thesis
• Thesis language: angličtina
• Department: Department of Pharmaceutical Chemistry and Pharmaceutical Analysis (16-16190)
• Supervisor: doc. RNDr. Veronika Opletalová, Ph.D.
• Author: hidden - assigned by the advisor
• Date of registration: 30.09.2013
• Date of assignment: 14.10.2013
• Date and time of defence: 01.06.2015 10:00
• Date of electronic submission: 13.05.2015
• Date of proceeded defence: 01.06.2015
• Opponents: PharmDr. Marta Kučerová, Ph.D.

Guidelines

The diploma thesis is a continuation of previous studies aimed at the synthesis of biologically active derivatives pyrazine. It was found that the amidoximes exhibited poor biological effects, but they can serve as intermediates for the synthesis of other potential drugs.
The aim of the present diploma thesis is to review reactions used to transform amidoximes in other derivatives. In experimental part, the student will try some of these reactions to get products for biological testing. All experiments will be performed under the supervision of a tutor, and all fire and safety precautions will be strictly observed.
Simultaneously, the student will study literature essential for the in-depth understanding of the topic and writing the theoretical part of the thesis. The thesis will have approximately 50 pages (font 11 or 12, line spacing 1.5) and will be divided into the following chapters:
1. Introduction and the aim of the work
2. Theorerical part
3. Experimental part
4. Discussion
5. Conclusions
6. References (approx. 50 items)

References

On-line databases (e. g. PubMed, Medline, Web of Science, Reaxys)
Original papers in journals, books and patents
Previous diploma theses as examples for the formal arrangment of the diploma thesis.