Úloha Akt kinázy v kardioprotektivních mechanismech chronické hypoxie
| Thesis title in Czech: | Úloha Akt kinázy v kardioprotektivních mechanismech chronické hypoxie |
|---|---|
| Thesis title in English: | The role of Akt kinase in cardioprotective mechanisms induced by chronic hypoxia |
| Key words: | Akt kináza, adaptace na hypoxii, srdce, kardioprotektivní mechanismy |
| English key words: | Akt kinase, adaptation to hypoxia, heart, cardioprotective mechanisms |
| Academic year of topic announcement: | 2012/2013 |
| Thesis type: | diploma thesis |
| Thesis language: | čeština |
| Department: | Department of Physiology (31-152) |
| Supervisor: | doc. RNDr. Jitka Žurmanová, Ph.D. |
| Author: | hidden - assigned by the advisor |
| Date of registration: | 20.11.2012 |
| Date of assignment: | 20.11.2012 |
| Date of electronic submission: | 15.08.2016 |
| Date of proceeded defence: | 12.09.2016 |
| Opponents: | RNDr. Anna Svatoňová, Ph.D. |
| Preliminary scope of work |
| Adaptace na chronickou hypoxii snižuje míru ischemicko-reperfúzního (I/R) poškození . Cílem práce je stanovit míru aktivace AKT signální dráhy v levé komoře potkana v průběhu I/R poškození u normoxických a hypoxických zvířat (10% O2) s ohledem na zvýšnou aktivitou mitochondriální hexokinázy po ischemické inzultu. |
| Preliminary scope of work in English |
| Adaptation to chronic hypoxia reduces the rate of ischemic reperfusion (I / R) injury. The aim ot the theses is to determine the degree of activation of Akt signaling pathway in left ventricle during I / R damage in normoxic and hypoxic rats (10% O2). with respect to the increase of mitochondrial hexokinase activity after the ischemic insult. |