Plasticita po ložiskovém mozkovém poškození

• Název práce v češtině: Plasticita po ložiskovém mozkovém poškození
• Název v anglickém jazyce: Plasticity after focal brain ischemia
• Klíčová slova: Ischemické poškození, mozková kůra, zvířecí modely, obnova funkce, plasticita
• Klíčová slova anglicky: Ischemic injury, cortex, animal models, recovery, plasticity
• Akademický rok vypsání: 2010/2011
• Typ práce: bakalářská práce
• Jazyk práce: čeština
• Ústav: Klinika rehabilitace a tělovýchovného lékařství (13-432)
• Vedoucí / školitel: prof. MUDr. Pavel Mareš, DrSc.
• Řešitel: skrytý - zadáno a potvrzeno stud. odd.
• Datum přihlášení: 20.01.2011
• Datum zadání: 20.01.2011
• Datum a čas obhajoby: 24.05.2011 08:40
• Datum odevzdání elektronické podoby: 01.05.2011
• Datum odevzdání tištěné podoby: 15.04.2011
• Datum proběhlé obhajoby: 24.05.2011
• Oponenti: PaedDr. Irena Zounková, Ph.D.

Seznam odborné literatury

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Předběžná náplň práce

Práce se zabývá problematikou fokální mozkové ischemie s důrazem na následné plastické změny v mozku, které mohou mít vliv na návrat motorické funkce.
V obecné části jsou vysvětleny základní pojmy týkající se mozkové kůry, klasifikace mozkové ischemie, ischemického ložiska, ischemických změn včetně reperfuzního poškození a spontánních autoreparačních procesů.
V hlavní části jsou rešeršně zpracovány výsledky soudobých studií zabývajících se modelem korové fokální ischemie u laboratorního potkana a vlivu rehabilitace na neuroplasticitu a obnovu motorické funkce.

Předběžná náplň práce v anglickém jazyce

The thesis appropriate to approach brain ischemia injury with the wiew of subsequent spontaneous and rehabilitation-induced plastic changes related to motor recovery.
In general part there is described cortex anatomy and brain ischaemia patophysiology including notions about ischemia classification, ischemic cascade and reperfusion injury. There is also chapter about spontaneous plasticity and recovery.
The main part is about contemporary rat models of focal cortical ischemia, about function assement and rehabilitative training and there are presented results of rehabilitation-induced cortical plasticity.