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Súčasné trendy v terapii dyslipidémií
Název práce v jazyce práce (slovenština): Súčasné trendy v terapii dyslipidémií
Název práce v češtině: Současné trendy v terapií dyslipidémií
Název v anglickém jazyce: Current trends in dyslipidemia therapy
Akademický rok vypsání: 2020/2021
Typ práce: diplomová práce
Jazyk práce: slovenština
Ústav: Katedra biologických a lékařských věd (16-16150)
Vedoucí / školitel: prof. PharmDr. Petr Nachtigal, Ph.D.
Řešitel: skrytý - zadáno vedoucím/školitelem
Datum přihlášení: 29.09.2021
Datum zadání: 23.02.2023
Datum a čas obhajoby: 30.05.2023 08:00
Datum odevzdání elektronické podoby:05.05.2023
Datum proběhlé obhajoby: 30.05.2023
Oponenti: PharmDr. Katarína Tripská, Ph.D.
 
 
 
Zásady pro vypracování
Literární rešerše
Praktická experimentální část
Sepsání diplomové práce
Obhajoba diplomové práce
Seznam odborné literatury
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2. Alt, A., Miguel-Romero, L., Donderis, J., Aristorena, M., Blanco, F. J., Round, A., Rubio, V., Bernabeu, C., and Marina, A. (2012) Structural and functional insights into endoglin ligand recognition and binding. PloS one 7, e29948
3. Lopez-Novoa, J. M., and Bernabeu, C. (2010) The physiological role of endoglin in the cardiovascular system. Am J Physiol Heart Circ Physiol 299, H959-974
4. Bot, P. T. G., Hoefer, I. E., Sluijter, J. P. G., Vliet, P. v., Smits, A. M., Lebrin, F., Moll, F., Vries, J.-P. d., Doevendans, P., Piek, J. J., Pasterkamp, G., and Goumans, M.-J. (2009) Increased Expression of the Transforming Growth Factor-β Signaling Pathway, Endoglin, and Early Growth Response-1 in Stable Plaques. Stroke 40, 439-447
5. St-Jacques, S., Forte, M., Lye, S. J., and Letarte, M. (1994) Localization of endoglin, a transforming growth factor-beta binding protein, and of CD44 and integrins in placenta during the first trimester of pregnancy. Biol Reprod 51, 405-413
6. Meurer, S., Wimmer, A. E., van de Leur, E., and Weiskirchen, R. (2019) Endoglin Trafficking/Exosomal Targeting in Liver Cells Depends on N-Glycosylation. Cells 8, 997
7. Lastres, P., Bellon, T., Cabanas, C., Sanchez-Madrid, F., Acevedo, A., Gougos, A., Letarte, M., and Bernabeu, C. (1992) Regulated expression on human macrophages of endoglin, an Arg-Gly-Asp-containing surface antigen. Eur J Immunol 22, 393-397
8. Aristorena, M., Gallardo-Vara, E., Vicen, M., de Las Casas-Engel, M., Ojeda-Fernandez, L., Nieto, C., Blanco, F. J., Valbuena-Diez, A. C., Botella, L. M., Nachtigal, P., Corbi, A. L., Colmenares, M., and Bernabeu, C. (2019) MMP-12, Secreted by Pro-Inflammatory Macrophages, Targets Endoglin in Human Macrophages and Endothelial Cells. Int J Mol Sci 20
9. Hawinkels, L. J., Kuiper, P., Wiercinska, E., Verspaget, H. W., Liu, Z., Pardali, E., Sier, C. F., and ten Dijke, P. (2010) Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis. Cancer Res 70, 4141-4150
10. Blazquez-Medela, A. M., Garcia-Ortiz, L., Gomez-Marcos, M. A., Recio-Rodriguez, J. I., Sanchez-Rodriguez, A., Lopez-Novoa, J. M., and Martinez-Salgado, C. (2010) Increased plasma soluble endoglin levels as an indicator of cardiovascular alterations in hypertensive and diabetic patients. BMC Med 8, 86
11. Igreja Sa, I. C., Tripska, K., Hroch, M., Hyspler, R., Ticha, A., Lastuvkova, H., Schreiberova, J., Dolezelova, E., Eissazadeh, S., Vitverova, B., Najmanova, I., Vasinova, M., Pericacho, M., Micuda, S., and Nachtigal, P. (2020) Soluble Endoglin as a Potential Biomarker of Nonalcoholic Steatohepatitis (NASH) Development, Participating in Aggravation of NASH-Related Changes in Mouse Liver. Int J Mol Sci 21
12. Blaha, M., Cermanova, M., Blaha, V., Jarolim, P., Andrys, C., Blazek, M., Maly, J., Smolej, L., Zajic, J., Masin, V., Zimova, R., and Rehacek, V. (2008) Elevated serum soluble endoglin (sCD105) decreased during extracorporeal elimination therapy for familial hypercholesterolemia. Atherosclerosis 197, 264-270
13. Leanos-Miranda, A., Navarro-Romero, C. S., Sillas-Pardo, L. J., Ramirez-Valenzuela, K. L., Isordia-Salas, I., and Jimenez-Trejo, L. M. (2019) Soluble Endoglin As a Marker for Preeclampsia, Its Severity, and the Occurrence of Adverse Outcomes. Hypertension 74, 991-997
14. Santibañez, J. F., Quintanilla, M., and Bernabeu, C. (2011) TGF-β/TGF-β receptor system and its role in physiological and pathological conditions. Clin Sci (Lond) 121, 233-251
15. Munoz-Felix, J. M., Gonzalez-Nunez, M., and Lopez-Novoa, J. M. (2013) ALK1-Smad1/5 signaling pathway in fibrosis development: friend or foe? Cytokine Growth Factor Rev 24, 523-537
16. Rossi, E., Sanz-Rodriguez, F., Eleno, N., Duwell, A., Blanco, F. J., Langa, C., Botella, L. M., Cabanas, C., Lopez-Novoa, J. M., and Bernabeu, C. (2013) Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration. Blood 121, 403-415
17. Vicen, M., Vitverova, B., Havelek, R., Blazickova, K., Machacek, M., Rathouska, J., Najmanova, I., Dolezelova, E., Prasnicka, A., Sternak, M., Bernabeu, C., and Nachtigal, P. (2019) Regulation and role of endoglin in cholesterol-induced endothelial and vascular dysfunction in vivo and in vitro. FASEB J 33, 6099-6114
18. Ceriello, A., Quagliaro, L., Piconi, L., Assaloni, R., Da Ros, R., Maier, A., Esposito, K., and Giugliano, D. (2004) Effect of postprandial hypertriglyceridemia and hyperglycemia on circulating adhesion molecules and oxidative stress generation and the possible role of simvastatin treatment. Diabetes 53, 701-710
19. Liu, Y., Paauwe, M., Nixon, A. B., and Hawinkels, L. (2020) Endoglin Targeting: Lessons Learned and Questions That Remain. Int J Mol Sci 22
20. Liu, Y., Tian, H., Blobe, G. C., Theuer, C. P., Hurwitz, H. I., and Nixon, A. B. (2014) Effects of the combination of TRC105 and bevacizumab on endothelial cell biology. Invest New Drugs 32, 851-859
21. Madonna, R., Montebello, E., Lazzerini, G., Zurro, M., and De Caterina, R. (2010) NA+/H+ exchanger 1- and aquaporin-1-dependent hyperosmolarity changes decrease nitric oxide production and induce VCAM-1 expression in endothelial cells exposed to high glucose. Int J Immunopathol Pharmacol 23, 755-765
22. Brcakova, E., Fuksa, L., Cermanova, J., Kolouchova, G., Hroch, M., Hirsova, P., Martinkova, J., Staud, F., and Micuda, S. (2009) Alteration of methotrexate biliary and renal elimination during extrahepatic and intrahepatic cholestasis in rats. Biol Pharm Bull 32, 1978-1985
23. Puig-Kroger, A., Relloso, M., Fernandez-Capetillo, O., Zubiaga, A., Silva, A., Bernabeu, C., and Corbi, A. L. (2001) Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells. Blood 98, 2175-2182
24. Li, H., Yao, J., Chang, X., Wu, J., Duan, T., and Wang, K. (2018) LIFR increases the release of soluble endoglin via the upregulation of MMP14 expression in preeclampsia. Reproduction 155, 297-306
25. Liu, R., Shen, H., Wang, T., Ma, J., Yuan, M., Huang, J., Wei, M., and Liu, F. (2018) TRAF6 mediates high glucose-induced endothelial dysfunction. Exp Cell Res 370, 490-497
26. Quagliaro, L., Piconi, L., Assaloni, R., Da Ros, R., Maier, A., Zuodar, G., and Ceriello, A. (2005) Intermittent high glucose enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: the distinct role of protein kinase C and mitochondrial superoxide production. Atherosclerosis 183, 259-267
27. Hemling, P., Zibrova, D., Strutz, J., Sohrabi, Y., Desoye, G., Schulten, H., Findeisen, H., Heller, R., Godfrey, R., and Waltenberger, J. (2020) Hyperglycemia-induced endothelial dysfunction is alleviated by thioredoxin mimetic peptides through the restoration of VEGFR-2-induced responses and improved cell survival. Int J Cardiol 308, 73-81
28. Lv, Z. H., Phuong, T. A., Jin, S. J., Li, X. X., and Xu, M. (2017) Protection by simvastatin on hyperglycemia-induced endothelial dysfunction through inhibiting NLRP3 inflammasomes. Oncotarget 8, 91291-91305
29. La Sala, L., Pujadas, G., De Nigris, V., Canivell, S., Novials, A., Genovese, S., and Ceriello, A. (2015) Oscillating glucose and constant high glucose induce endoglin expression in endothelial cells: the role of oxidative stress. Acta Diabetol 52, 505-512
30. Sanchez-Elsner, T., Botella, L. M., Velasco, B., Langa, C., and Bernabeu, C. (2002) Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways. J Biol Chem 277, 43799-43808
31. van Uden, P., Kenneth, N. S., and Rocha, S. (2008) Regulation of hypoxia-inducible factor-1alpha by NF-kappaB. Biochem J 412, 477-484
32. Kumar, S., Pan, C. C., Bloodworth, J. C., Nixon, A. B., Theuer, C., Hoyt, D. G., and Lee, N. Y. (2014) Antibody-directed coupling of endoglin and MMP-14 is a key mechanism for endoglin shedding and deregulation of TGF-β signaling. Oncogene 33, 3970-3979
33. Blankenberg, S., Barbaux, S., and Tiret, L. (2003) Adhesion molecules and atherosclerosis. Atherosclerosis 170, 191-203
34. Liu, Y., Starr, M. D., Brady, J. C., Dellinger, A., Pang, H., Adams, B., Theuer, C. P., Lee, N. Y., Hurwitz, H. I., and Nixon, A. B. (2014) Modulation of circulating protein biomarkers following TRC105 (anti-endoglin antibody) treatment in patients with advanced cancer. Cancer Med 3, 580-591
 
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