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Vplyv glukózy na expresiu biomarkerov endotelové dysfunkcie u endotelových buniek.
Název práce v jazyce práce (slovenština): Vplyv glukózy na expresiu biomarkerov endotelové dysfunkcie u endotelových buniek.
Název práce v češtině: Vliv glukózy na expresi biomarkerů endotelové dysfunkce u endotelových buněk.
Název v anglickém jazyce: Glucose effects on the expression of biomarkers of endothelial dysfunction in endothelial cells
Akademický rok vypsání: 2019/2020
Typ práce: diplomová práce
Jazyk práce: slovenština
Ústav: Katedra biologických a lékařských věd (16-16150)
Vedoucí / školitel: prof. PharmDr. Petr Nachtigal, Ph.D.
Řešitel: skrytý - zadáno vedoucím/školitelem
Datum přihlášení: 14.10.2019
Datum zadání: 25.02.2021
Datum a čas obhajoby: 02.06.2021 09:00
Datum odevzdání elektronické podoby:29.05.2021
Datum proběhlé obhajoby: 02.06.2021
Oponenti: PharmDr. Petra Fikrová, Ph.D.
 
 
 
Zásady pro vypracování
Literární rešerše
Praktická část - RT-PCR a průtoková cytometrie
Diskuse
Závěry
Seznam odborné literatury
1. Nachtigal, P., Zemankova Vecerova, L., Rathouska, J., and Strasky, Z. (2012) The role of endoglin in atherosclerosis. Atherosclerosis 224, 4-11
2. Venkatesha, S., Toporsian, M., Lam, C., Hanai, J., Mammoto, T., Kim, Y. M., Bdolah, Y., Lim, K. H., Yuan, H. T., Libermann, T. A., Stillman, I. E., Roberts, D., D'Amore, P. A., Epstein, F. H., Sellke, F. W., Romero, R., Sukhatme, V. P., Letarte, M., and Karumanchi, S. A. (2006) Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med 12, 642-649
3. Hawinkels, L. J., Kuiper, P., Wiercinska, E., Verspaget, H. W., Liu, Z., Pardali, E., Sier, C. F., and ten Dijke, P. (2010) Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis. Cancer Res 70, 4141-4150
4. Botella, L. M., Sanchez-Elsner, T., Sanz-Rodriguez, F., Kojima, S., Shimada, J., Guerrero-Esteo, M., Cooreman, M. P., Ratziu, V., Langa, C., Vary, C. P., Ramirez, J. R., Friedman, S., and Bernabeu, C. (2002) Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury. Blood 100, 4001-4010
5. Ollauri-Ibanez, C., Lopez-Novoa, J. M., and Pericacho, M. (2017) Endoglin-based biological therapy in the treatment of angiogenesis-dependent pathologies. Expert Opin Biol Ther 17, 1053-1063
6. Sanchez-Elsner, T., Botella, L. M., Velasco, B., Langa, C., and Bernabeu, C. (2002) Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways. J Biol Chem 277, 43799-43808
7. van Uden, P., Kenneth, N. S., and Rocha, S. (2008) Regulation of hypoxia-inducible factor-1alpha by NF-kappaB. Biochem J 412, 477-484
8. Valbuena-Diez, A. C., Blanco, F.J., Oujo, B. et al. (2012) Oxysterol-induced soluble endoglin release and its involment in hypertension. In Circulation pp. 2612-2624
9. Toporsian, M., Gros, R., Kabir, M. G., Vera, S., Govindaraju, K., Eidelman, D. H., Husain, M., and Letarte, M. (2005) A role for endoglin in coupling eNOS activity and regulating vascular tone revealed in hereditary hemorrhagic telangiectasia. Circ Res 96, 684-692
10. Jerkic, M., Rivas-Elena, J. V., Prieto, M., Carron, R., Sanz-Rodriguez, F., Perez-Barriocanal, F., Rodriguez-Barbero, A., Bernabeu, C., and Lopez-Novoa, J. M. (2004) Endoglin regulates nitric oxide-dependent vasodilatation. FASEB J 18, 609-611
11. Rossi, E., Sanz-Rodriguez, F., Eleno, N., Duwell, A., Blanco, F. J., Langa, C., Botella, L. M., Cabanas, C., Lopez-Novoa, J. M., and Bernabeu, C. (2013) Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration. Blood 121, 403-415
12. Rossi, E., Pericacho, M., Bachelot-Loza, C., Pidard, D., Gaussem, P., Poirault-Chassac, S., Blanco, F. J., Langa, C., Gonzalez-Manchon, C., Novoa, J. M. L., Smadja, D. M., and Bernabeu, C. (2018) Human endoglin as a potential new partner involved in platelet-endothelium interactions. Cell Mol Life Sci 75, 1269-1284
13. Steinberg, D. (2002) Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime. Nat Med 8, 1211-1217
14. Levitan, I., Volkov, S., Subbaiah, P.V. (2010) Oxidized LDL: Diversity, Patterns of Recognition, and Pathophysiology. In Antioxidants & Redox Signaling pp. 39-75
15. Chalubinski, M., Zemanek, K., Skowron, W., Wojdan, K., Gorzelak, P., and Broncel, M. (2013) The effect of 7-ketocholesterol and 25-hydroxycholesterol on the integrity of the human aortic endothelial and intestinal epithelial barriers. Inflamm Res 62, 1015-1023
16. Olkkonen, V. M., Beaslas, O., Nissila, E. (2012) Oxysterols and their cellular effectors. In Biomolecules pp. 76-103
17. Hayden, J. M., Brachova, L., Higgins, K., Obermiller, L., Sevanian, A., Khandrika, S., and Reaven, P. D. (2002) Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol. J Lipid Res 43, 26-35
18. Rathouska, J., Jezkova, K., Nemeckova, I., and Nachtigal, P. (2015) Soluble endoglin, hypercholesterolemia and endothelial dysfunction. Atherosclerosis 243, 383-388
19. Strasky, Z., Vecerova, L., Rathouska, J., Slanarova, M., Brcakova, E., Kudlackova, Z., Andrys, C., Micuda, S., and Nachtigal, P. (2011) Cholesterol effects on endoglin and its downstream pathways in ApoE/LDLR double knockout mice. Circ J 75, 1747-1755
20. Zemankova, L., Varejckova, M., Dolezalova, E., Fikrova, P., Jezkova, K., Rathouska, J., Cerveny, L., Botella, L. M., Bernabeu, C., Nemeckova, I., and Nachtigal, P. (2015) Atorvastatin-induced endothelial nitric oxide synthase expression in endothelial cells is mediated by endoglin. J Physiol Pharmacol 66, 403-413
21. Ruiz-Remolina, L., Ollauri-Ibanez, C., Perez-Roque, L., Nunez-Gomez, E., Perez-Barriocanal, F., Lopez-Novoa, J. M., Pericacho, M., and Rodriguez-Barbero, A. (2017) Circulating soluble endoglin modifies the inflammatory response in mice. PLoS One 12, e0188204
22. Ishibashi, S., Herz, J., Maeda, N., Goldstein, J. L., and Brown, M. S. (1994) The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins. Proc Natl Acad Sci U S A 91, 4431-4435
23. Csanyi, G., Gajda, M., Franczyk-Zarow, M., Kostogrys, R., Gwozdz, P., Mateuszuk, L., Sternak, M., Wojcik, L., Zalewska, T., Walski, M., and Chlopicki, S. (2012) Functional alterations in endothelial NO, PGI(2) and EDHF pathways in aorta in ApoE/LDLR-/- mice. Prostaglandins & other lipid mediators 98, 107-115
24. Jawien, J., Csanyi, G., Gajda, M., Mateuszuk, L., Lomnicka, M., Korbut, R., and Chlopicki, S. (2007) Ticlopidine attenuates progression of atherosclerosis in apolipoprotein E and low density lipoprotein receptor double knockout mice. Eur J Pharmacol 556, 129-135
25. Yamagata, K., Tanaka, N., and Suzuki, K. (2013) Epigallocatechin 3-gallate inhibits 7-ketocholesterol-induced monocyte-endothelial cell adhesion. Microvasc Res 88, 25-31
26. Kij, A., Mateuszuk, L., Sitek, B., Przyborowski, K., Zakrzewska, A., Wandzel, K., Walczak, M., and Chlopicki, S. (2016) Simultaneous quantification of PGI2 and TXA2 metabolites in plasma and urine in NO-deficient mice by a novel UHPLC/MS/MS method. J Pharm Biomed Anal 129, 148-154
27. Przyborowski, K., Wojewoda, M., Sitek, B., Zakrzewska, A., Kij, A., Wandzel, K., Zoladz, J. A., and Chlopicki, S. (2015) Effects of 1-Methylnicotinamide (MNA) on Exercise Capacity and Endothelial Response in Diabetic Mice. PLoS One 10, e0130908
28. Vitverova, B., Blazickova, K., Najmanova, I., Vicen, M., Hyspler, R., Dolezelova, E., Nemeckova, I., Tebbens, J. D., Bernabeu, C., Pericacho, M., and Nachtigal, P. (2018) Soluble endoglin and hypercholesterolemia aggravate endothelial and vessel wall dysfunction in mouse aorta. Atherosclerosis 271, 15-25
29. Nemeckova, I., Serwadczak, A., Oujo, B., Jezkova, K., Rathouska, J., Fikrova, P., Varejckova, M., Bernabeu, C., Lopez-Novoa, J. M., Chlopicki, S., and Nachtigal, P. (2015) High soluble endoglin levels do not induce endothelial dysfunction in mouse aorta. PLoS One 10, e0119665
30. Puig-Kroger, A., Relloso, M., Fernandez-Capetillo, O., Zubiaga, A., Silva, A., Bernabeu, C., and Corbi, A. L. (2001) Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells. Blood 98, 2175-2182
31. Dopico, A. M., Bukiya, A. N., and Jaggar, J. H. (2018) Calcium- and voltage-gated BK channels in vascular smooth muscle. Pflugers Arch
32. Santibanez, J. F., Letamendia, A., Perez-Barriocanal, F., Silvestri, C., Saura, M., Vary, C. P., Lopez-Novoa, J. M., Attisano, L., and Bernabeu, C. (2007) Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent TGF-beta signaling. J Cell Physiol 210, 456-468
33. Kaitu'u-Lino, T. J., Palmer, K. R., Whitehead, C. L., Williams, E., Lappas, M., and Tong, S. (2012) MMP-14 Is Expressed in Preeclamptic Placentas and Mediates Release of Soluble Endoglin. American Journal of Pathology 180, 888-894
34. Kaczara, P., Proniewski, B., Lovejoy, C., Kus, K., Motterlini, R., Abramov, A. Y., and Chlopicki, S. (2018) CORM-401 induces calcium signalling, NO increase and activation of pentose phosphate pathway in endothelial cells. FEBS J 285, 1346-1358
35. Gallardo-Vara, E., Blanco, F. J., Roque, M., Friedman, S. L., Suzuki, T., Botella, L. M., and Bernabeu, C. (2016) Transcription factor KLF6 upregulates expression of metalloprotease MMP14 and subsequent release of soluble endoglin during vascular injury. Angiogenesis 19, 155-171
36. Henry-Berger, J., Mouzat, K., Baron, S., Bernabeu, C., Marceau, G., Saru, J. P., Sapin, V., Lobaccaro, J. M., and Caira, F. (2008) Endoglin (CD105) expression is regulated by the liver X receptor alpha (NR1H3) in human trophoblast cell line JAR. Biol Reprod 78, 968-975
37. Lawrence, T. (2009) The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol 1, a001651
38. Mbalaviele, G., Sommers, C. D., Bonar, S. L., Mathialagan, S., Schindler, J. F., Guzova, J. A., Shaffer, A. F., Melton, M. A., Christine, L. J., Tripp, C. S., Chiang, P. C., Thompson, D. C., Hu, Y., and Kishore, N. (2009) A novel, highly selective, tight binding IkappaB kinase-2 (IKK-2) inhibitor: a tool to correlate IKK-2 activity to the fate and functions of the components of the nuclear factor-kappaB pathway in arthritis-relevant cells and animal models. J Pharmacol Exp Ther 329, 14-25
39. Vecerova, L., Strasky, Z., Rathouska, J., Slanarova, M., Brcakova, E., Micuda, S., and Nachtigal, P. (2012) Activation of TGF-beta receptors and Smad proteins by atorvastatin is related to reduced atherogenesis in ApoE/LDLR double knockout mice. J Atheroscler Thromb 19, 115-126
40. Brownfoot, F. C., Hannan, N., Onda, K., Tong, S., and Kaitu'u-Lino, T. (2014) Soluble endoglin production is upregulated by oxysterols but not quenched by pravastatin in primary placental and endothelial cells. Placenta 35, 724-731
 
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