Vliv glukokortikoidní léčby na muskuloskeletální aparát dětských pacientů s akutní lymfoblastickou leukemií

• Název práce v češtině: Vliv glukokortikoidní léčby na muskuloskeletální aparát dětských pacientů s akutní lymfoblastickou leukemií
• Název v anglickém jazyce: Impact of glucocorticoid treatment on musculosceletal system of pediatric patients with acute lymphoblastic leukemia.
• Klíčová slova: akutní lymfoblastická leukemie, glukokortikoidy, svalová síla, pohybové programy, osteonekróza, kostní minerální denzita
• Klíčová slova anglicky: acute lymphoblastic leukemia, glucocorticoids, muscle strength, exercise programs, osteonecrosis, bone mineral density
• Akademický rok vypsání: 2016/2017
• Typ práce: bakalářská práce
• Jazyk práce: čeština
• Ústav: Klinika rehabilitace a tělovýchovného lékařství (13-432)
• Vedoucí / školitel: Mgr. MgA. Filip Jevič
• Řešitel: skrytý - zadáno vedoucím/školitelem
• Datum přihlášení: 17.05.2017
• Datum zadání: 20.04.2018
• Datum potvrzení stud. oddělením: 17.05.2017
• Datum a čas obhajoby: 22.05.2018 08:00
• Datum odevzdání elektronické podoby: 23.04.2018
• Datum odevzdání tištěné podoby: 23.04.2018
• Datum proběhlé obhajoby: 22.05.2018
• Oponenti: doc. MUDr. Lucie Šrámková, Ph.D.

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Předběžná náplň práce

Tato rešeršní bakalářská práce se zabývá problematikou komplikací muskuloskeletálního systému u dětských pacientů s diagnózou akutní lymfoblastické leukemie (ALL), kteří podstupují chemoterapeutickou léčbu zahrnující vysoké kumulativní dávky glukokortikoidů. Mezi muskuloskeletální komplikace řadíme steroidní myopatii, osteonekrózu a sníženou kostní minerální denzitu. V přehledu poznatků jsou uvedeny jejich základní patofyziologické mechanismy a rizikové faktory jejich vzniku. Ve speciální části jsou představeny současné možnosti hodnocení svalové síly a dostupné pohybové programy. Dále je shrnuta diagnostika osteonekrózy a kostní minerální denzity s dosavadními možnostmi terapeutických intervencí.
Součástí práce je charakteristika metod měření svalové síly a pohybových programů s uvedením výsledků, kterých bylo v jednotlivých studiích dosaženo. V diskuzi jsou rozebrány limity, výhody a nedostatky využití metod měření svalové síly a pohybových programů v klinické praxi.

Předběžná náplň práce v anglickém jazyce

This bachelor thesis aims to provide a general overview of complications of musculoskeletal system in pediatric patients diagnosed with acute lymphoblastic leukemia (ALL) undergoing chemotherapy treatment involving high cumulative doses of glucocorticoids. Musculoskeletal complications include steroid myopathy, osteonecrosis and reduced bone mineral density. The first part describes their basic pathophysiological mechanisms and the risk factors of their origin. The second part presents the current possibilities of muscle strength assessment and available exercise programs. Furthermore, diagnosis of osteonecrosis and bone mineral density are presented together with current possibilities of therapeutic intervention.
The thesis also covers characteristics of muscle strength measuring methods and exercise programs along with presentation of the results of individual studies. In the discussion part, there are broken down the limits, advantages and disadvantages of using the muscle strength measuring methods and exercise programs in clinical practice.