Predikce poškození střeva u novorozenců s gastroschízou

• Název práce v češtině: Predikce poškození střeva u novorozenců s gastroschízou
• Název v anglickém jazyce: Prediction of intestinal damage in neonates with gastroschisis
• Klíčová slova: jednoduchá gastroschíza, komplexní gastroschíza, i-FABP v moči, prenatální ultrazvukové vyšetření, kvalita života
• Klíčová slova anglicky: simple gastroschisis, complex gastroschisis, urinary I-FABP, prenatal ultrasound, quality of life
• Akademický rok vypsání: 2014/2015
• Typ práce: disertační práce
• Jazyk práce: čeština
• Ústav: Klinika dětské chirurgie (13-381)
• Vedoucí / školitel: prof. MUDr. Michal Rygl, Ph.D.
• Řešitel: skrytý - zadáno a potvrzeno stud. odd.
• Datum přihlášení: 02.04.2015
• Datum zadání: 02.04.2015
• Datum potvrzení stud. oddělením: 02.04.2015
• Datum a čas obhajoby: 23.09.2019 12:30
• Datum odevzdání elektronické podoby: 15.05.2019
• Datum odevzdání tištěné podoby: 15.05.2019
• Datum proběhlé obhajoby: 23.09.2019
• Oponenti: doc. MUDr. Tomáš Pešl, Ph.D.

Seznam odborné literatury

1. Brebner A, Czuzoj-Shulman N, Abenhaim HA: Prevalence and predictors of mortality in gastroschisis: a population-based study of 4803 cases in the USA. J Matern Fetal Neonatal Med. 2018 Nov 26:1-7.

2. Rahul SK, Yadav R, Kumar V. et al.: Left Sided Gastroschisis. J Neonatal Surg. 2017 Apr 15;6(2):53.

3. Wood SJ, Samangaya RA, Gillham JC, et al: Gastroschisis and the risk of short bowel syndrome: outcomes and counselling. Neonatology 2014, 105:5–8.


4. Phillips JD, Raval MV, Redden C, et al.: Gastroschisis, atresia, dysmotility: surgical treatment strategies for a distinct clinical entity. J Pediatr Surg 2008, 43:2208–2212.

5. Hill SJ, Durham MM: Management of cryptorchidism and gastroschisis. J Pediatr Surg. 2011 Sep;46(9):1798-803.

6. Holcomb GW, Murphy JD, Ostlie DJ. Ashcraft‘s Pediatric Surgery, Elsevier 2014:660−72.

7. Rittler M et al.: Gastroschisis and young mothers: What makes them different from other mothers of the same age? Birth Defects Res A Clin Mol Teratol. 2015 Jun;103(6):536-43.

8. Lap CC, Brizot ML, Pistorius LR, et al. Outcome of isolated gastroschisis; an international study, systematic review and meta-analysis. Early Hum Dev 2016;103:209−18.


9. Coufal S, Kokesova A, Tlaskalova-Hogenova H, et al.: Urinary Intestinal Fatty Acid-Binding Protein Can Distinguish Necrotizing Enterocolitis from Sepsis in Early Stage of the Disease. J Immunol Res. 2016; 2016:5727312.

10. Bingold TM, Franck K, Holzer K, et al.: Intestinal Fatty Acid Binding Protein: A Sensitive Marker in Abdominal Surgery and Abdominal Infection. Surg Infect (Larchmt). 2015; 16(3):247–53.

11. Derikx JP, Evennett NJ, Degraeuwe PL, et al.: Urine based detection of intestinal mucosal cell damage in neonates with suspected necrotising enterocolitis. Gut. 2007; 56(10):1473–5.

12. Phelan JP, Smith CV, Broussard P, et al: Amniotic fluid volume assessment with the four-quadrant technique at 36–42 weeks’ gestation. J Reprod Med 1987, 32:540–542.

13. Pet GE, Stark RA, Meehan JJ, et al. Outcomes of bedside sutureless umbilical closure without endotracheal intubation for gastroschisis repair in surgical infants. Am J Surg 2017; 213:958−62. 


14. Bianchi A, Dickson AP.: Elective delayed reduction and no anesthesia:‚minimal in- tervention management‘ for gastrochisis. J Pediatr Surg 1998;33:1338−40. 


15. Kobzova J,Vignerova J,Blaha P, et al.: The 6th nationwide anthropological survey of children and adolescents in the Czech Republic in 2001. Central European Journal Of Public Health 2004;12(3):126-30. 


16. Kuleva M, Khen-Dunlop N, Dumez Y,et al.: Is complex gastroschisis predictable by prenatal ultrasound? BJOG 2012, 119:102–109. 


17. Huh NG, Hirose S, Goldstein RB: Prenatal intraabdominal bowel dilation is associated with postnatal gastrointestinal complications in fetuses with gastroschisis. Am J Obstet Gynecol 2010, 202(396):e391–e396. 


18. Nick AM, Bruner JP, Moses R, et al.: Second-trimester intra-abdominal bowel dilation in fetuses with gastroschisis predicts neonatal bowel atresia. Ultrasound Obstet Gynecol 2006, 28:821–825.

19. Janoo J, Cunningham M, Hobbs GR, et al.: Can antenatal ultrasounds help predict postnatal outcomes in babies born with gastroschisis? The West Virginia experience. W V Med J 2013:109:22–27.

20. Ghionzoli M, James CP, David AL et al.: Gastroschisis with intestinal atresia–predictive value of antenatal diagnosis and outcome of postnatal treatment. J Pediatr Surg 2012, 47:322–328

21. Chen CP, Liu FF, Jan SW et al.: Prenatal diagnosis and perinatal aspects of abdominal wall defects. Am J Perinatol 1996, 13:355–361.


22. Capelle X, Schaaps JP, Foidart JM: Prenatal care and postnatal outcome for fetuses with laparoschisis. J Gynecol Obstet Biol Reprod , Paris, 2007, 36:486–495.

23. Johnston R, Haeri S: Oligohydramnios and growth restriction do not portend worse prognosis in gastroschisis pregnancies. J Matern Fetal Neonatal Med. 2016 Dec;29(24):4055-8.

24. Badillo AT, Hedrick HL, Wilson RD et al.: Prenatal ultrasonographic gastrointestinal abnormalities in fetuses with gastroschisis do not correlate with postnatal outcomes. J Pediatr Surg 2008: 43:647–653 


25. Kunz SN, Tieder JS, Whitlock K, et al: Primary fascial closure versus staged closure with silo in patients with gastroschisis: a meta-analysis. J Pediatr Surg. 2013; 48(4):845–57. 

26. Grootjans J, Lenaerts K, Buurman WA, et al: Life and death at the mucosal-luminal interface: New perspectives on human intestinal ischemia-reperfusion. World J Gastroenterol. 2016; 22 (9):2760–70. 


27. Caglar M, Karaguzel G, Gokhan-Ocak G, et al.: Multidirectional and simultaneous evaluation of gastroschisis-related intestinal damage in chick embryos. J Pediatr Surg. 2014; 49(11):1577–84.

28. Eleftheriadis E, Kotzampassi K, Papanotas K., et al: Gut ischemia, oxidative stress, and bacterial translocation in elevated abdominal pressure in rats. World J Surg. 1996; 20(1):11–6.


29. Koivusalo A, Lindahl H, Rintala RJ.: Morbidity and quality of life in adult patients with a congenital abdominal wall defect: a questionnaire surfy, J Pediatr Surg 2002;37(11):1594-601. 


30. Kaiser MM, Kahl F, von Schwabe C, et al: Omphalocele and gastroschisis. Outcome--complications--follow-up--quality of life. Chirurg 2000;71(10):1256-62.


31. Tunell WP, Puffinbarger NK, Tuggle DW, et al.: Abdominal wall defects in infants. Survival and implications for adult life. Ann Surg 1995;221(5):525-8; discussion 528-30.

32. Halsband H, von Schwabe C.: Long term results and quality of life of children with omphalocele and gastroschisis. Langenbecks Arch Chir Suppl II Verh Dtsch Ges Chir 1989:951-5. 


33. Sawicka E, Płoska-Urbanek B, Michalak J, et al.: Advances in treatment of congenital gastroschisis based on personal examinations. Med Wieku Rozwoj 2000;4(2):197-205. 


34. Ing C, DiMaggio CJ, Whitehouse A, et al.: Long-term differences in language and cognitive function after childhood exposure to anesthesia. Pediatrics 2012;130(3):e476-85.

35. Aker J, Block RI, Biddle C.: Anesthesia and the developing brain. AANA J 2015;83(2):139-47. 


36. Chemaly M, El-Rajab MA, Ziade FM, et al.: Effect of one anesthetic exposure on long-term behavioral changes in children. J Clin Anesth 2014;26(7):551-6.

37. Lunzer H, Menardi G, Brezinka C.: Long-term follow-up of children with prenatally diagnosed omphalocele and gastroschisis. J Matern Fetal Med 2001;10(6):385-92.

38. Harris EL, Hart SJ, Minutillo C, et al.: The long-term neurodevelopmental and psychological outcomes of gastroschisis: A cohort study. J Pediatr Surg 2016;51(4):549-53.

39. Henrich K, Huemmer HP, Reingruber B., et al.: Gastroschisis and omphalocele: treatments and long-term outcomes. Pediatr Surg Int 2008;24(2):167-73.

40. Davies BW, Stringer MD.: The survivors of gastroschisis. Arch Dis Child 1997;77(2):158-60. 


41. Piaseczna-Piotrowska A, Jóźwiak A.: Ileus due to adhesions as a consequence of abdominal surgery in childhood - analysis of 94 cases. Med Wieku Rozwoj 2011;15(1):91-5.

Předběžná náplň práce

Cíl práce: Cílem práce bylo najít prenatální ultrazvukové nálezy u plodu a biochemický marker u novorozence s gastroschízou, které by dokázaly predikovat pooperační vývoj klinického stavu novorozence a rychlost obnovy funkce střeva, dále zavést do praxe chirurgickou techniku kpostupnému uzávěru defektu břišní stěny – preformované silikonové silo pro gastroschízu a zhodnotit kvalitu života dítěte s gastroschízou.

Předběžná náplň práce v anglickém jazyce

The aim of the study was to identify both prenatal ultrasonographic markers in fetuses and a biochemical marker in newborns with gastroschisis that predict postnatal outcome; to perform a new technique of defect closure by preformed silicone silo for gastroschisis and to evaluate long-term quality of life and somatic growth of patients with gastroschisis and compare them with the general population.