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Detail práce
  
Effects of antidepressants and depressive disorders on mitochondrial functions
Název práce v češtině: Vliv antidepresiv a depresivní poruchy na mitochondriální funkce
Název v anglickém jazyce: Effects of antidepressants and depressive disorders on mitochondrial functions
Klíčová slova: antidepresiva, stabilizátory nálady, deprese, mitochondrie, elektronový transportní řetězec, citrátový cyklus, oxidativní fosforylace
Klíčová slova anglicky: antidepressants, mood stabilizers, depression, mitochondria, electron transport chain, citric acid cycle, oxidative phosphorylation
Akademický rok vypsání: 2011/2012
Typ práce: rigorózní práce
Jazyk práce: angličtina
Ústav: Katedra farmakologie a toxikologie (16-16170)
Vedoucí / školitel: prof. RNDr. Zdeněk Fišar, CSc.
Řešitel: skrytý - zadáno a potvrzeno stud. odd.
Datum přihlášení: 20.06.2012
Datum zadání: 20.06.2012
Datum potvrzení stud. oddělením: 24.03.2015
Datum a čas obhajoby: 19.02.2015 00:00
Datum odevzdání elektronické podoby:23.04.2014
Datum proběhlé obhajoby: 19.02.2015
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Předběžná náplň práce
V tomto projektu byly studovány jednak in vitro účinky různých antidepresiv a stabilizátorů nálady na mitochondriální funkce, jednak změny vybraných mitochondriálních funkcí osob s depresivními poruchami. Měření byla prováděna nejprve na izolovaných mitochondriích ze zvířecích mozků (in vitro model), poté na krevních destičkách depresivních pacientů. Byly měřeny účinky farmakologicky odlišných antidepresiv a stabilizátorů nálady na mitochondrie izolované ze zvířecích mozků (in vitro model). Aktivita izoforem monoaminooxidasy (MAO) byla stanovena radiochemicky, aktivity dalších mitochondriálních enzymů spektrofotometricky. Celková aktivita systému oxidační fosforylace byla určena respirometrií s vysokým rozlišením. Metody byly modifikovány pro měření stejných parametrů v krevních destičkách u pacientů s depresivní epizodou a u zdravých kontrol. Cílem projektu bylo zjistit, zda jsou mitochondriální funkce antidepresivy, stabilizátory nálady a depresí významně ovlivněny a zda mohou být využity jako prediktory odezvy na léčbu antidepresivy nebo biologické markery depresivní poruchy.
Předběžná náplň práce v anglickém jazyce
In our project, in vitro effects of pharmacologically different antidepressants and mood-stabilisators on mitochondrial functions were studied as well as selected mitochondrial functions in patients with depressive disorders. In vitro effects of pharmacologically different antidepressants and mood stabilizers on the activities of mitochondrial enzymes were measured in mitochondria isolated from pig brains (in vitro model). Activity of monoamine oxidase (MAO) isoforms was determined radiochemically, activities of other mitochondrial enzymes were measured spectrophotometrically. Overall activity of the system of oxidative phosphorylation was measured electrochemically using high-resolution respirometry. Methods were modified to measure the same parameters in blood platelets of patients with depressive episode and healthy controls. The aim of the study was to find out, whether mitochondrial functions are affected by antidepressants, mood stabilizers and depression, and can be further used as biological markers of depressive disorders.
 
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