Témata prací (Výběr práce)Témata prací (Výběr práce)(verze: 368)
Detail práce
   Přihlásit přes CAS
Vliv kouření matky na homeostázu fetoplacentární jednotky
Název práce v češtině: Vliv kouření matky na homeostázu fetoplacentární jednotky
Název v anglickém jazyce: The effect of maternal smoking on the homeostasis of the fetoplacental unit
Klíčová slova: kouření v těhotenství, steroidní hormony, fyziologické rozmezí, plod, novorozenec
Klíčová slova anglicky: smoking in pregnancy, steroids, physiological range, fetus, newborn
Akademický rok vypsání: 2014/2015
Typ práce: disertační práce
Jazyk práce: čeština
Ústav: Klinika gynekologie, porodnictví a neonatologie 1. LF UK a VFN (11-00790)
Vedoucí / školitel: prof. MUDr. Antonín Pařízek, CSc.
Řešitel: skrytý - zadáno a potvrzeno stud. odd.
Datum přihlášení: 07.10.2014
Datum zadání: 07.10.2014
Datum potvrzení stud. oddělením: 07.10.2014
Datum a čas obhajoby: 17.06.2021 11:00
Místo konání obhajoby: Fyziologický ústav 1. LF UK
Datum odevzdání elektronické podoby:22.04.2021
Datum proběhlé obhajoby: 17.06.2021
Předmět: Obhajoba dizertační práce (B90002)
Oponenti: prof. PhDr. Michal Miovský, Ph.D.
  prof. MUDr. Martin Procházka, Ph.D.
 
 
Konzultanti: MUDr. Michaela Dušková, Ph.D.
Seznam odborné literatury
1. Adamcová K, Dušková M, Pařízek A. Smoking in pregnancy-negative impacton mother and child. Opinions on nicotine substitution. Ceska Gynekol, 2015 Aug;80(4):264-70.
2. Adamcová K, Kolátorová L, Škodová T, Šimková M, Pařízek A, Stárka L, Dušková M. Changes to fetal steroidogenesis caused by maternal smoking. Physiol Res, 2017, sv. 66 (Suppl.3), s. 375–386.
3. Adamcová K, Kolátorová L, Škodová T, Šimková M, Pařízek A, Stárka L, Dušková M. Steroid hormone levels in the peripartum period – differences caused by fetal sex and delivery type. Physiol Res. 67, (Suppl. 3), 2018, 489–497.
4. Alfaidy N, Li W, Macintosh T, et al. Late gestation increase in 11betahydroxysteroid dehydrogenase 1 expression in human fetal membranes: a novel intrauterine source of cortisol. J Clin Endocrinol Metab, 2003; 88:5033–8.
5. Andersen AN, Rønn B, Tjønneland A, Djursing H, Schiøler V. Low maternal but normal fetal prolactin levels in cigarette smoking pregnant women. Acta Obstet Gynecol Scand, 1984; 63(3):237-9.
6. Archer DF, Mathur RS, Wiqvist N, Diczfalusy E. Quantitative assessment of the de novo sterol and steroid synthesis in the human foeto-placental unit. 2. Synthesis and secretion of steroids and steroid sulphates by the midgestation foetus. Acta Endocrinol (Copenh), 1971; 66:666–78.
7. Bader D, Riskin A, Vafsi O, Tamir A, Peskin B, Israel N, et al. Alphafetoprotein in the early neonatal period–a large study and review of the literature. Clin Chim Acta, 2004; 349:15–23.
8. Baron JA, Comi RJ, Cryns V, Brinck-Johnsen T, Mercer NG. The effect of cigarette smoking on adrenal cortical hormones. J Pharmacol Exp Ther, 1995, 272(1):151-5.
9. Begeot M, Dubois MP, Dubois PM.Immunologic localization of alpha- and beta-endorphins and beta-lipotropin in corticotropic cells of the normal and anencephalic fetal pituitaries. Cell Tissue Res, 1978; 193:413–22.
10. Benyu S, Wen Q, Feng X,Xiaomin W,Qiangdong G, Wenchong J, Shue W, Mengmeng X,Sufang Y. The relation of passive smoking with cervical cancer. Medicine (Baltimore), 2018 Nov; 97(46): e13061.
11. Blanks AM, Brosens JJ. Progesterone action in the myometrium and decidua in preterm birth. Facts Views Vis Obgyn, 2012; 4:33–43.
12. Brand JS, Hiyoshi A, Cao Y, Lawlor DA, Cnattingius S, Montgomery S. Maternal smoking during pregnancy and fractures in offspring: national register based sibling comparison study. BMJ, 2020; 368; 170-7.
13. Carlsen SM, Jacobsen G, Bjerve KS. Androgen levels in pregnant women decrease with increasing maternal age. Scand J Clin Lab Invest, 2003, 63(1):23-6.
14. Carlsen SM, Jacobsen G, Romundsrad P. Maternal testosterone levels during pregnancy are associated with offspring size at birth. Eur J Endocrinol, 2006, 155(2):365-70.
15. Carr BR, Simpson ER. De novo synthesis of cholesterol by the human fetal adrenal gland. Endocrinology, 1981; 108: 2154–62.
16. Carr BR, Simpson ER. Cholesterol synthesis in human fetal tissues. J Clin Endocrinol Metab, 1982; 55:447–52.
17. Cohen SH, Alexander DD, Krebs NF, Young BE, Cabana MD, Erdmann P, Hays NP, Bezold CP, Levin-Sparenberg E, Turini M, Saavedra JM. Factors Associated with Breastfeeding Initiation and Continuation: A Meta-Analysis. J Pediatr, 2018 Dec; 203: 190-196.
18. Coleman DT, Bancroft C. Nicotine acts directly on pituitary GH3 cells to inhibit prolactin promoter activity. J Neuroendocrinol, 1995,7(10):785-9.
19. Cooper GS, Baird DD, Hulka BS, Weinberg CR, Savitz DA, Hughes CL Jr. Follicle-stimulating hormone concentrations in relation to active and passive smoking. Obstet Gynecol, 1995, 85(3):407-11.
20. Corona G, Mannucci E, Petrone L, Ricca V, Mansani R, Cilotti A, Balercia B, Chiarini V, Giommi R, Forti G, Maggi M. Psychobiological correlates of smoking in patients with erectile dysfunction. International Journal of Impotence Research, 2005, 17, 527–534.
21. Crha I, Hrubá D. Kouření a reprodukce. 1. vyd., Brno: Masarykova univerzita, 2000, 54 s., ISBN 80-210-2284-1.
22. Cross J, Linker E, Leslie M. Sex-Dependent Effects of Nicotine on the Developing Brain. J Neurosci Res. 2017 Jan; 95(1-2):422-436.
23. Čech E, Hájek Z, Maršál K, Srp B. Porodnictví, Praha, 124-125, ISBN 80-247-1313-9, 2006.
24. De Hertogh R, Thomas K, Hoet JJ, Vanderheyden I. Plasma concentrations of unconjugated estrone, estradiol-17beta and estriol, and HCS throughout pregnancy in diabetics and gestational diabetics. Diabetologia, 1976; 12:455–61.
25. Di Pietro JA, Costigan KA, Kivlinghan KT, Chen P, Laudenslager ML. Maternal salivary cortisol differs by fetal sex during the second half of pregnancy. Psychoneuroendocrinology, 2011, 36(4):588-91.
26. Dechanet C, Anahory T, Mathieu Daude JC, Quantin X, Reyftmann L, Hamamah S, Hedon B, Dechaud H. Effects of cigarette smoking on reproduction. Hum Reprod Update, 2011, 17: 76-95.
27. Diczfaluzy E, Pion R, Schwers J. Steroid biogenesis and metabolism in the human foeto-placental unit at midpregnancy. Arch Anat Microsc Morphol Exp, 1965 Jan-Mar; 54:67-83.
28. Divers WA Jr, Wilkes MM, Babaknia A, Yen SS. Maternal smoking and elevation of catecholamines and metabolites in the amniotic fluid. Am J Obstet Gynecol, 1981, 141(6), 625–628.
29. Dušková M, Hruškovičová H, Šimůnková K, Stárka L, Pařízek A. The effects of smoking on steroid metabolism and fetal programming. J Steroid Biochem Mol Biol, 2014, 139, 138–143.
30. Dušková M, Kolátorová L, Stárka L. Androgens in women - critical evaluation of the methods for their determination in diagnostics of endocrine disorders. Physiol Res. 67 (Suppl 3), 2018, 379-390.
31. Dušková M, Kolátorová L, Šimková M, Šrámková M, Horáčková L, Vítků J, Stárka L. Steroid diagnostics of 21st century in the light of their new roles and analytical tools. Physiol Res, 69(Suppl 2), 2020; 193-203.
32. Dušková M, Šimůnková K, Hill M, Velíková M, Kubátová J, Kancheva L, Kazihnitková H, Hruškovičová H, Pospíšilová H, Rácz B, Salátová M, Cirmanová V, Králíková E, Stárka L, Pařízek A: Chronic cigarette smoking alters circulating sex hormones and neuroactive steroids in premenopausal women, Physiol Res, 2012; 61(1):97-111.
33. Emanuel RL, Robinson BG, Seely EW, et al. Corticotrophin releasing hormone levels in human plasma and amniotic fluid during gestation. Clin Endocrinol (Oxf), 1994; 40:257–62.
34. Fluck CE, Pandey AV. Steroidogenesis of the testis–new genes and pathways. Ann Endocrinol (Paris), 2014; 75:40–7.
35. Frederick SL, Reus VI, Ginsberg D, Hall SM, Munoz RF, Ellman G. Cortisol and response to dexamethasone as predictors of withdrawal distress and abstinence success in smokers. Biol Psychiatry, 1998, 43(7):525-30.
36. Freour T, Masson D, Mirallie S, Jean M, Bach K, Dejoie T, Barriere P. Active smoking compromises IVF outcome and affects ovarian reserve. Reprod Biomed Online, 2008, 16: 96-102.
37. Friedman AJ, Ravnikar VA, Barbieri RL. Serum steroid hormone profiles in postmenopausal smokers and nonsmokers. Fertil Steril, 1987, 47(3):398-401.
38. Fuxe K, Andersson K, Eneroth P, Härfstrand A, Agnati LF. Neuroendocrine actions of nicotine and of exposure to cigarette smoke: medical implications. Psychoneuroendocrinology, 1989,14(1-2):19-41.
39. Gilliland FD, Berhane K, McConnell R. Maternal smoking during pregnancy, environmental tobacco smoke exposure and childhood lung function. Thorax, 2000, 55, 271–276.
40. Gilliland FD, Li YF, Peters JM. Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med, 2001, 163, 429–436.
41. Glynn DA, Cryan JF, Kent P. Update on smoking cessation therapies. Adv Ther, 2009, 26, 369–382.
42. Gossain VV, Sherma NK, Srivastava L, Michelakis AM, Rovner DR. Hormonal effects of smoking--II: Effects on plasma cortisol, growth hormone, and prolactin. Am J Med Sci, 1986, 291(5):325-7.
43. Goto M, Brickwood S, Wilson DI, Wood PJ, Mason JI, Hanley NA. Steroidogenic enzyme expression within the adrenal cortex during early human gestation. Endocr Res, 2002; 28:641–5.
44. Guichard A, de Ikonicoff LK, Cedard L. [Delta 5–3 beta hydroxysteroid dehydrogenase activity in the human full term placenta after culture: the effect of chorionic gonatropin]. C R Acad Sci Hebd Seances Acad Sci D, 1975; 280:1481–4.
45. Gunes T, Koklu E, Yikilmaz A et al. Influence of maternal smoking on neonatal aortic intima–media thickness, serum IGF-I and IGFBP-3 levels. Eur J Pediatr, 2007 Jan 4, 166(10), 1039–1044.
46. Hanrahan JP, Tager IB, Segal MR. The effect of maternal smoking during pregnancy on early infant lung function. Am Rev Respir Dis, 1992, 145(5), 1129–1135.
47. Hart R, Sloboda DM, Doherty DA et al. Prenatal determinants of uterine volume and ovarian reserve in adolescence. J Clin Endocrinol Metab, 2009, 94(12), 4931–4937.
48. Hautanen A, Adlercreutz H. Hyperinsulinaemia, dyslipidaemia and exaggerated adrenal androgen response to adrenocorticotropin in male smokers. Diabetologia, 1993,36(12):1275-81.
49. Heussner K, Ruebner M, Huebner H, Rascher W, Menedez-Castro C, Hartner A, Fahlbusch FB, Rauh M. Species differences of 11beta-hydroxysteroid dehydrogenase type 2 function in human and rat term placenta determined via LC-MS/MS. Placenta. 2016, 37:79-84.
50. Hill M, Pařízek A, Jirásek JE, Jirkovská M, Velíková M, Dušková M, Klímková M, Pašková A, Žižka Z, Germanová A, Koucký M, Kalousová M, Stárka L. Is maternal progesterone actually independent of the fetal steroids? Physiol Res, 2010a, 59: 211-224.
51. Hill M, Pařízek A, Kancheva R, Dušková M, Velíková M, Kříž L, Klímková M, Pašková A, Žižka Z, Matucha P, Meloun M, Stárka L. Steroid metabolome in plasma from the umbilical artery, umbilical vein, maternal cubital vein and in amniotic fluid in normal and preterm labor. J Steroid Biochem Mol Biol, 2010b, 121: 594-610.
52. Hill M, Pařízek A, Velíková M, Kubátová J, Kancheva R, Dušková M, Šimůnková K, Klímková M, Pašková A, Žižka Z, Jirásek JE, Jirkovská M, Stárka L. The distribution of placental oxidoreductase isoforms provides different milieus of steroids influencing pregnancy in the maternal and fetal compartment. Horm Mol Biol Clin Invest, 2010c, 4(3): 581–600.
53. Hillebrand JJ, de Wied D, Adan RA. Neuropeptides, foodintake and body weight regulation: a hypothalamic focus. Peptides, 2002, 23, 2283–2306.
54. Holloway AC, Lim GE, Petrik JJ et al. Fetal and neonatal exposure to nicotine in Wistar rats results in increased beta cell apoptosis at birth and postnatal endocrine and metabolic changes associated with type 2 diabetes. Diabetologia, 2005, 48, 2661–2666.
55. Hrubá D. Kouření a reprodukce, 2004,http://www.med.muni.cz/prelek/zdravi/clanky/hruba/repro.html.
56. Hrubá D. Riziko kouření v těhotenství se stále podceňuje. Tolerovat kouření v těhotenství je neodborné a neetické. Prak Gynek, 2011, 15(1), 34–39.
57. Hruškovičová H, Bičíková M, Vondra K., Stárka L., Dušková M. Vztah neuroaktivních steroidnů a vybraných závislostí, DMEV, 2011, 14, 4:217-224.
58. Ingvarsson RF, Bjarnason AO, Dagbjartsson A, Hardardottir H, Haraldsson A, Thorkelsson T. The effects of smoking in pregnancy on factors influencing fetal growth. Acta Paediatr, 2007; 96(3):383-6.
59. Istvan JA, Buist AS, Hess DL, Voelker H.Relationship of smoking cessation and nicotine gum use to salivary androstenedione and testosterone in middle-aged men. Metabolism, 1994, 44: 90-95.
60. Jandíková H, Dušková M, Stárka L. Influence of smoking and smoking cessation on human reproductive hormonal balance. Physiol Res, 2017, Sep 26; 66(Suppl 3):323-331.
61. Jedrychowski W, Flak E. Maternal smoking during pregnancy and postnatal exposure to environmental tobacco smoke as predisposition factors to acute respiratory infections. Environmental Health Perspectives, 1997, 105(3), 302–306.
62. Kandel DB, Udry JR. Prenatal effects of maternal smoking on daughters‘ smoking: nicotine or testosterone exposure? Am J Public Health, 1999, 89(9), 1377–1383.
63. Kato I, Toniolo P, Koenig KL, Shore RE, Zeleniuch-Jacquotte A, Akhmedkhanov A, Riboli E. Epidemiologic correlates with menstrual cycle length in middle aged women. Eur J Epidemiol, 1999, 15: 809-814.
64. Kerkhof GF, Leunissen RW, Willemsen RH et al. Influence of preterm birth and birth size on gonadal function in young men. J Clin Endocrinol Metab, 2009, 94(11), 4243–4250.
65. Kirschbaum C, Wüst S, Strasburger CJ. 'Normal' cigarette smoking increases free cortisol in habitual smokers. Life Sci. 1992,50(6):435-42.
66. Klak J, Hill M, Parizek A, Havlikova H, Bicikova M, Hampl R, Fait T, Sulcova J, Pouzar V, Kancheva R, Starka L. Pregnanolone isomers, pregnenolone and their polar conjugates around parturition. Physiol Res, 2003; 52:211–21.
67. Králíková E, Bajerová J, Raslová N et al. Smoking and pregnancy: prevalence, knowledge, antrophometry, risk communication. PMR, 2005, 106(2), 195–200.
68. Kuijper EA, Ket JC, Caanen MR, Lambalk CB. Reproductive hormone concentrations in pregnancy and neonates: a systematic review. Reprod Biomed Online, 2013 Jul; 27(1):33-63.
69. Kuijper EA, Twisk JW, Korsen T, Caanen MR, Kushnir MM, Rockwood AL, Meikle AW, Hompes PG, Wit JM, Lambalk CB. Mid-pregnancy, perinatal, and neonatal reproductive endocrinology: a prospective cohort study in twins and singleton control subjects. Fertil Steril. 2015; 104(6):1527-34.
70. Lackmann GM, Salzberger U, Tollner U et al. Metabolites of a tobacco-specific carcinogen in urine from newborns. J Natl Cancer Inst, 1999, 91, 459–465.
71. Lawrence J, Xiao D, Xue Q et al. Prenatal nicotine exposure increases heart susceptibility to ischemia/reperfusion injury in adult offspring. J Pharmacol Exp Ther, 2008, 324, 331–341.
72. Lieberman E, Torday J, Barbieri R, Cohen A, Van Vunakis H, Weiss ST. Association of intrauterine cigarette smoke exposure with indices of fetal lung maturation. Obstet Gynecol, 1992 Apr; 79(4):564-70.
73. Linton EA, Woodman JR, Asboth G, et al. Corticotrophin releasing hormone: its potential for a role in human myometrium. Exp Physiol, 2001; 86:273–81.
74. Main KM, Skakkebaek NE, Toppari J. Cryptorchidism as part of the testicular dysgenesis syndrome: the environmental connection. Endocr Dev, 2009, 14, 167–173.
75. Manjer J, Johansson R, Lenner P. Smoking as a determinant for plasma levels of testosterone, androstenedione, and DHEAs in postmenopausal women. Eur J Epidemiol, 2005,20(4): 331-7.
76. Mastorakos G, Ilias I. Maternal and fetal hypothalamic-pituitary-adrenal axes during pregnancy and postpartum. Ann N Y Acad Sci, 2003, 997:136-49.
77. McCarthy M. Estradiol and developing brain. Physiol Rev, 2008, 88: 91-134.
78. McDonald SD, Walker M, Perkins SL, Beyene J, Murphy K, Gibb W, Ohlsson A. The effect of tobacco exposure on the fetal hypothalamic-pituitary-adrenal axis. , BJOG, 2006 Nov; 113(11):1289-95.
79. McLean M, Bisits A, Davies J, et al. A placental clock controlling the length of human pregnancy. Nat Med, 1995; 1:460–3.
80. McLean M, Smith R. Corticotrophin-releasing hormone and human parturition. Reproduction. 121(4):493-501, 2001.
81. Meeker CI, DeCesaris V, Tulp O. Metabolism of 7-3 H-pregnenolone in normal human placenta maintained in organ culture. Am J Obstet Gynecol, 1971; 111:840–5.
82. Mendelsohn C, Gould G, Oncken C. Management of smoking in pregnant women. Austr Fam Physician, 2014, 43, 46–51.
83. Mendelson CR. Minireview: fetal-maternal hormonal signaling in pregnancy and labor. Mol Endocrinol 2009; 23:947–54
84. Mesiano S, Wang Y, Norwitz ER. Progesterone receptors in the human pregnancy uterus: do they hold the key to birth timing? Reprod Sci, 2011; 18:6–19.
85. Michnovicz JJ, Hershcopf RJ, Naganuma H, Bradlow HL, Fishman J. Increased 2-hydroxylation of estradiol as a possible mechanism for the anti-estrogenic effect of cigarette smoking. N Engl J Med, 1986, 315(21):1305-9.
86. Mitchell EA, Milerad J. Smoking and the sudden infantdeath syndrome. Rev Environ Health, 2006, 21, 81–103.
87. Montgomery SM, Ekbom A. Smoking during pregnancy and diabetes mellitus in a British longitudinal birth cohort. BMJ, 2002, 324–326.
88. Morel Y, Roucher F, Plotton I, Goursaud C, Tardy V, Mallet D. Evolution of steroids during pregnancy: Maternal, placental and fetal synthesis. Ann Endocrinol. 2016 Jun;77(2):82-9.
89. Natali A, Mondaini N, Lombardi G, Del Popolo G, Rizzo M. Heavy smoking is an important risk factor for erectile dysfunction in young men. Int J Impot Res, 2005 May-Jun,17(3):227-30.
90. Nechanská B, Mravčík V, Sopko B, Velebil P. Rodičky užívající alkohol, tabák a nelegální drogy. Ces Gynek, 2012, 77(5), 457–469.
91. Nodwell A, Carmichael L, Fraser M, et al. Placental release of corticotrophin-releasing hormone across the umbilical circulation of the human newborn. Placenta, 1999; 20:197–202.
92. Ochedalski T, Lachowicz-Ochedalska A, Dec W, Czechowski B. Examining the effects of tobacco smoking on levels of certain hormones in serum of young men. Ginekol Pol, 1994, 65(2):87-93.
93. Okuyemi KS, Ahluwalia JS, Harris KJ. Pharmacotherapy of smoking cessation. Arch Fam Med, 2000, 9, 270–281.
94. Pařízek A, Mikešová M, Jirák R, Hill M, Koucký M, Pašková A, Velíková M, Adamcová K, Šrámková M, Jandíková H, Dušková M, Stárka L. Steroid hormones in the development of postpartum depression. Physiol Res. 63 Suppl 2, 2014: 277-282.
95. Pařízek A, Dušková M, Vítek L, Šrámková M, Hill M, Adamcová K, Šimják P, Černý A, Kokrdová Z, Vráblíková H, Boudová B, Koucký M, Malíčková K, Stárka L. The role of steroid hormones in the development of intrahepatic cholestasis of pregnancy. Physiol Res 64 (Suppl. 2), 2015: 203-210.
96. Pařízek A, Hill M, Dušková M, Vítek L, Velíková M, Kancheva K, Šimják P, Koucký M, Kokrdová Z, Adamcová K, Černý A, Hájek Z, Stárka L. A comprehensive evaluation of steroid metabolism in women with intrahepatic cholestasis of pregnancy. PLoS One, 2016 11(8): e0159203.
97. Pašková A, Pařízek A, Hill M, Velíková M, Kubátová J, Dušková M, Adamcová K, Koucký M, Šimják P, Černý A, Stárka L.Steroid metabolome in the umbilical cord: is it necessary to differentiate between arterial and venous blood? Physiol Res 63, 2014: 115-126.
98. Pasqualini JR, Chetrite GS. The formation and transformation of hormones in maternal, placental and fetal compartments: biological implications. Horm Mol Biol Clin Investig, 2016; 27(1):11-28.
99. Pasqualini JR, Kincl FA, editors. Hormones and the fetus, vol. 1. Oxford: Pergamon Press, 1985:73–172.
100. Pasqualini JR. Enzymes involved in the formation and transformation of steroid hormones in the fetal and placental compartments. J Steroid Biochem Mol Biol, 2005; 97:401–15.
101. Patterson TR, Stringham JD, Meikle AW. Nicotine and cotinine inhibit steroidogenesis in mouse Leydig cells. Life Sci, 1990, 46(4):265-72.
102. Peters MJ, Morgan LC. The pharmacotherapy of smoking cessation. Med J Aust, 2002, 176, 486–490.
103. Pezzi V, Mathis JM, Rainey WE, Carr BR. Profiling transcript levels for steroidogenic enzymes in fetal tissues. J Steroid Biochem Mol Biol, 2003; 87:181–9
104. Pineles BL, Park E, Samet JM. Systematic Review and Meta-Analysis of Miscarriage and Maternal Exposure to Tobacco Smoke During Pregnancy.Am J Epidemiol, 2014 Apr 1; 179(7): 807–823.
105. Power C, Atherton K, Thomas C. Maternal smoking in pregnancy, adult adipozity and other risk factors for cardiovascular disease. Atherosclerosis. 2010 Aug; 643-648.
106. Ramlau-Hansen CH, Thulstrup AM, Olsen J, Ernst E, Andersen CY, Bonde JP. Maternal smoking in pregnancy and reproductive hormones in adult sons. Int J Androl, 2008; 31(6):565-72.
107. Ratcliffe JM, Gladen BC, Wilcox AJ, Herbst AL. Does early exposure to maternal smoking affect future fertility in adult males? Reprod Toxicol, 1992; 6(4):297-307.
108. Ravanos K, Dagklis T, Petousis S, Margioula-Siarkou Ch, Prapas Y, Prapas N. Factors implicated in the initiation of human parturition in term and preterm labor: a review, Gynecol Endocrinol, 2015;31(9):679-83.
109. Rode L., Kjærgaard H., Damm P., et al. Effect of Smoking Cessation on Gestational and Postpartum Weight Gain and Neonatal Birth Weight. Obstet Gynecol, 2013 Sep; 122(3):618-25.
110. Salazar G, Phil M, Albala C, Yáñez M, Serón-Ferré M, Vio F. Smoking effects on prolactin at the end of pregnancy. Nutrition Research, 1995,15(11): 1599-1604.
111. Salvini S, Stampfer MJ, Barbieri RL, Hennekens CH. Effects of age, smoking and vitamins on plasma DHEAS levels: a cross-sectional study in men. J Clin Endocrinol Metab, 1992,74(1):139-43.
112. Saridjan NS, Huizink AC, Koetsier JA, Jaddoe VW, Mackenbach JP, Hofman A, Kirschbaum C, Verhulst FC, Tiemeier H. Do social disadvantage and early family adversity affect the diurnal cortisol rhythm in infants? The Generation R Study. Horm Behav. 2010 Feb; 57(2):247-54.
113. Schuetze P, Lopez FA, Granger DA, Eiden RD. The association between prenatal exposure to cigarettes and cortisol reactivity and regulation in 7-month-old infants. Dev Psychobiol, 2008 Dec; 50(8):819-34.
114. Shaarawy M, Mahmoud KZ. Endocrine profile and semen characteristics in male smokers. Fertil Steril, 1982 Aug,38(2):255-7.
115. Seyler LE Jr, Pomerleau OF, Fertig JB, Hunt D, Parker K. Pituitary hormone response to cigarette smoking. Pharmacol Biochem Behav, 1986,24(1):159-62
116. Shah T, Sullivan K, Carter J. Sudden infant death syndrome and reported maternal smoking during pregnancy. Am J Public Health, 2006 October, 96 (10), 1757-1759.
117. Slotkin TA, Saleh JL, McCook EC, Seidler FJ. Impaired cardiac function during postnatal hypoxia in rats exposed to nicotine prenatally: implications for perinatal morbidity and mortality, and for sudden infant death syndrome. Teratology, 1997, 55, 177–184.
118. Smith LM, Cloak CC, Poland RE, Torday J, Ross MG. Prenatal nicotine increases testosterone levels in the fetus and female offspring. Nicotine Tob Res, 2003; 5(3):369-74.
119. Soares SR, Melo MA. Cigarette smoking and IVF. Obstet Gynec, 2008, 3(4), 555–563.
120. Somm E, Schwitzgebel VM, Vauthay DM et al. Prenatal nicotine exposure alters early pancreatic islet and adipose tissue development with consequences on the control of body weight and glucose metabolism later in life. Endocrinology, 2008, 149, 6289–6299.
121. Soneji S, Beltrán-Sánchez H. Association of Maternal Cigarette Smoking and Smoking Cessation With Preterm Birth. JAMA Netw Open., 2019, Apr; 2(4): e192514.
122. Sosvorová L, Vítků J, Chlupáčová T, Mohapl M, Hampl R. Determination of seven selected neuro- and immunomodulatory steroids in human cerebrospinal fluid and plasma using LC-MS/MS. Steroids 98, 2015a: 1-8.
123. Sosvorová L,Hill M, Mohapl M, Vítků J, Hampl R. Steroid hormones in prediction of normal pressure hydrocephalus. J Steroid Biochem Mol Biol, 2015b, 152:124-32.
124. Sowers MF, Beebe JL, McConnell D, Randolph J, Jannausch M. Testosterone concentrations in women aged 25-50 years: associations with lifestyle, body composition, and ovarian status. Am J Epidemiol, 2001,153(3):256-64.
125. Speroff, L. and Fritz, M. (2005) The clinical gynecologic endocrinology and infertility. 7th Edition, Lippincott Williams & Wilkins, Philadelphia.
126. Stárka L., Hill M., Králíková E. Kouření a endokrinní systém. DMEV, 2005 8: 180-186.
127. Strauss JF, Barbieri RB. Yen and Jaffe’s Reproductive Endocrinology. 5th Edition, 2004, 340.
128. Stroud LR, Papandonatos GD, Shenassa E, Rodriguez D, Niaura R, LeWinn KZ, Lipsitt LP, Buka SL. Prenatal glucocorticoids and maternal smoking during pregnancy independently program adult nicotine dependence in daughters: a 40-year prospective study. Biol Psychiatry, 2014; 75(1):47-55.
129. Sun K, Brockman D, Campos B, et al. Induction of surfactant protein A expression by cortisol facilitates prostaglandin synthesis in human chorionic trophoblasts. J Clin Endocrinol Metab, 2006; 91: 4988–94.
130. Šimůnková K, Marek J. CBG - nejen transportní protein. DMEV, 2012; 15: 251-257.
131. Tagawa N, Hidaka Y, Takano T, Shimaoka Y, Kobayashi Y, Amino N. Serum concentrations of androstenediol and androstenediol sulfate, and their relation to cytokine production during and after normal pregnancy. Steroids, 2004 Sep; 69(10):675-80.
132. Tankó LB, Christiansen C. An update on the antiestrogenic effect of smoking: a literature review with implications for researchers and practitioners. Menopause 11: 104-109, 2004.
133. Tansavatdi K, McClain B, Herrington DM. The effects of smoking on estradiol metabolism. Minerva Ginecol 56: 105-114, 2004.
134. Thomford PJ, Mattioson DR. The effect of cigarette smoking on female reproduction. J Ark Med Soc, 1986, 82: 597-604.
135. Tong VT, England LJ, Dietz PM, Asare LA. Smoking patterns and use of cessation interventions during pregnancy. Am J Prev Med, 2008, 35, 327–333.
136. Troisi R, Hoover RN, Thadhani R, Hsieh CC, Sluss P, Ballard-Barbash R, Potischman N. Maternal, prenatal and perinatal characteristics and first trimester maternal serum hormone concentrations. Br J Cancer. 2008, 99(7):1161-4.
137. Trummer H, Habermann H, Haas J, Pummer K. The impact of cigarette smoking on human semen parameters and hormones. Hum Reprod, 2002, 17(6):1554-9.
138. Vannuccini S, Bocchi C, Severi FM, Challis JR, Petralgia F. Endocrinology of human parturition. Ann Endocrinol, 2016, Jun, 77 (2): 105-13.
139. Varvarigou AA, Liatsis SG, Vassilakos P, Decavalas G, Beratis NG.Effect of maternal smoking on cord blood estriol, placental lactogen, chorionic gonadotropin, FSH, LH, and cortisol. J Perinat Med, 2009; 37(4):364-9.
140. Varvarigou AA, Petsali M, Vassilakos P, Beratis NG. Increased cortisol concentrations in the cord blood of newborns whose mothers smoked during pregnancy. J Perinat Med, 2006, 34(6), 466–470.
141. Vaz LR, Leonardi-Bee J, Aveyard P et al. Factors associated with smoking cessation in early and late pregnancy in the smoking, nicotine, and pregnancy trial: A Trial of Nicotine Replacement Therapy. Nicotine Tob Res, 2014, 16(4), 381–389.
142. Velasco E, Malacara JM, Cervantes F, de León JD, Dávalos G, Castillo J. Gonadotropins and prolactin serum levels during the perimenopausal period: correlation with diverse factors. Fertil Steril, 1990 ,53(1):56-60
143. Vítků J, Chlupáčová T, Sosvorová L, Hampl R, Hill M, Heráček J, Biciková M, Stárka L. Development and validation of LC-MS/MS method for quantification of bisphenol A and estrogens in human plasma and seminal fluid. Atlanta, 2015, 140: 62-67.
144. Vítků J, Heráček J, Sosvorová L, Hampl R, Chlupáčová T, Hill M, Sobotka V, Biciková M, Stárka L. Associations of bisphenol A and polychlorinated biphenyls with spermatogenesis and steroidogenesis in two biological fluids from men attending an infertility clinic. Environ Int, 2016, 89-90: 166-173.
145. Voutilainen R, Miller WL. Developmental expression of genes for the steroidogenic enzymes P450cc (20,22 desmolase), P450c17 (17 alpha hydroxylase/17,20 lyase) and P450c21 (21-hydroxylase) in the human fetus. J Clin Endocrinol Metab, 1986; 63:1145–50.
146. Waddell BJ. The placenta as hypothalamus and pituitary. Possible impact on maternal and fetal adrenal function. Reprod Fertil, 1993 Dec, 5:479.
147. Weigert M, Hofstetter G, Kaipl D, Gottlich H, Krischker U, Bichler K, Poehl M, Feichtinger W. The effect of smoking on oocyte quality and hormonal parameters of patients undergoing in vitro fertilization-embryo transfer. J Assist Reprod Genet, 1999,16(6):287-93.
148. Wideroe M, Vik T, Jacobsen G, Bakketeig LS. Does maternal smoking during pregnancy cause childhood overweight? Paediatr Perinat Epidemiol, 2003, 17, 171–179.
149. Wilkins JN, Carlson HE, Van Vunakis H, Hill MA, Gritz E, Jarvik ME. Nicotine from cigarette smoking increases circulating levels of cortisol, growth hormone, and prolactin in male chronic smokers. Psychopharmacology (Berl), 1982,78(4):305-8.
150. Windham GC, Elkin EP, Swan SH, Waller KO, Fenster L. Cigarette smoking and effects on menstrual function. Obstet Gynecol, 1999, 93: 59-65.
Předběžná náplň práce
Kouření ženy v těhotenství představuje závažné zdravotní riziko pro matku a zejména pro její dítě. Kouření cigaret vyvolává u žen komplexní změny steroidogeneze v průběhu celého života. Ke sledování vlivu kouření na fetoplacentární jednotku se zaměřením na steroidní hormony bylo nutné nejprve zmapovat změny vybraných steroidů kolem porodu.
První část práce je zaměřená na sledování vybraných steroidních hormonů v peripartálním období (37. týden těhotenství, I. doba porodní u matek a smíšená pupečníková krev jejich novorozenců) a hledání vztahů k věku matky, nárůstu tělesné hmotnosti během těhotenství, typu porodu a pohlaví plodu.
Zajímavé bylo porovnání steroidů ve vztahu k typu porodu: vaginální porod versus plánovaný císařský řez. U žen nekuřaček, které čekaly hocha a rodily spontánně byly nalezeny signifikantně vyšší hladiny 17-OH-pregnenolonu, progesteronu, kortizolu, kortikosteronu a signifikantně nižší hladiny estradiolu oproti nekuřačkám, které čekaly hocha a rodily plánovaným císařským řezem. V mateřské krvi ve 37. týdnu těhotenství byly podle pohlaví plodu zjištěny rozdíly mezi steroidy, což se neprokázalo u novorozenců. Věk matky, nárůst tělesné hmotnosti a porodní hmotnost novorozence neměly vztah k žádnému ze sledovaných steroidů. Byla vytvořena referenční rozmezí pro sledované steroidy měřené LC-MS/MS.
Ve druhé části práce jsme sledovali změny tvorby steroidních hormonů u těhotných kuřaček. Tato část byla zaměřena na změny steroidogeneze v krvi matek ve 37. týdnu těhotenství a ve smíšené pupečníkové krvi jejich novorozenců.
Ve skupině žen, které čekaly hocha, byly u kuřaček ve 37. týdnu těhotenství proti nekuřačkám vyšší sérové hladiny kortizonu, DHEA, 7α-OH–DHEA, 17-OH-pregnenolonu, testosteronu
a androstendionu. Ve skupině žen, které čekaly děvče, byly u kuřaček ve 37. týdnu těhotenství nižší sérové hladiny 7β-OH-DHEA a vyšší hladiny androstendionu. U novorozených hochů byly zjištěny
u potomků kuřaček vyšší hladiny testosteronu. U novorozených děvčat byly u kuřaček nižší hladiny 7α-OH–DHEA. Kouření v těhotenství vyvolává změny v tvorbě steroidů, jak u těhotných žen, tak
u jejich potomků.
Výsledky prezentované v této práci mohou přispět k lepšímu pochopení fyziologických změn steroidních hormonů v peripartálním období a k ozřejmění důsledků kouření v těhotenství na možné patofyziologické změny v celkovém nastavení steroidní osy.
Předběžná náplň práce v anglickém jazyce
Maternal smoking causes serious health danger for a mother but especially for a baby. Cigarette smoking produces complex steroidogenesis changes during the whole life of a woman. To study the influence of smoking on fetoplacental unit focusing on steroid hormons it was important first to concentrate on changes of the chosen steroids around the delivery.
The first part of the thesis is dedicated to observe some chosen steroid hormons in peripartal period (37th week of the pregnancy, first stage of labor of mothers and mixed umbilical blood of their neonates) and to look for relations to the age of mother, the increase of the weight during the pregnancy, the type of the delivery and the sex of the baby.
It was interesting to compare steroids in the relation to the type of the delivery: vaginal delivery versus planned caesarean section. Non-smoking women who delivered a boy spontaneously had significantly higher level of 17-OH-pregnenolone, progesterone, cortisol, corticosterone and significantly lower level of estradiol in comparison with non-smoking women who delivered a boy by a planned Caesarean section. In the maternal blood in the 37th week of the pregnancy there were found differences between steroids in accordance to the sex of the fetus but they were not found in the neonates’ case. The age of mother, the increase of the human weight and the birth weight of the neonate didn’t have any relation to any of the observed steroids. There were created reference ranges for observed steroids measured by LC-MS/MS.
In the second part my thesis was monitoring changes of the creation of steroid hormons of smoking mothers. This part was focused on changes of steroidogenesis in blood of mothers in the 37th week of their pregnancy and in mixed umbilical blood of their neonates.
In the group of women who were expecting a boy there were smoking women in the 37th week who had higher serum levels of cortisone, DHEA, 7α-OH-DHEA, 17-OH-pregnenolone, testosterone and androstenedione in comparison with non-smoking women. In the group of women who were expecting a girl there were smoking women in the 37th week who had lower serum levels of 7β-OH-DHEA and higher levels of androstenedione. There were detected higher levels of testosterone at the boys of smoking mothers. But at the girls of smoking mothers there were detected lower levels of 7α-OH-DHEA. Smoking during pregnancy causes changes in the creation of steroids not only in the case of pregnant women but also in the case of their children.
The results shown in this thesis can help to understand better physiological changes of steroid hormons in peripartal period and to clarify impacts of smoking in pregnancy on possible patophysiological changes in overall setting of steroid axis.
 
Univerzita Karlova | Informační systém UK