Témata prací (Výběr práce)Témata prací (Výběr práce)(verze: 368)
Detail práce
   Přihlásit přes CAS
Vliv stresu na periferii a v CNS s ohledem na úlohu muskarinových receptorů
Název práce v češtině: Vliv stresu na periferii a v CNS s ohledem na úlohu muskarinových receptorů
Název v anglickém jazyce: The effects of stress on the periphery and in the central nervous system with respect to the role of muscarinic receptors
Klíčová slova: M2 muskarinové receptory, stres, biorytmus, CRH, integrační úloha hypotalamu
Klíčová slova anglicky: M2 muscarinic receptors, stress, biological rhytms, CRH, hypothalamic integration
Akademický rok vypsání: 2013/2014
Typ práce: disertační práce
Jazyk práce: čeština
Ústav: Fyziologický ústav 1. LF UK (11-00150)
Vedoucí / školitel: prof. MUDr. Jaromír Mysliveček, Ph.D., MBA
Řešitel: skrytý - zadáno a potvrzeno stud. odd.
Datum přihlášení: 04.08.2014
Datum zadání: 04.08.2014
Datum potvrzení stud. oddělením: 04.08.2014
Datum a čas obhajoby: 17.03.2022 10:00
Místo konání obhajoby: Fyziologický ústav 1. LF UK
Datum odevzdání elektronické podoby:14.02.2022
Datum proběhlé obhajoby: 17.03.2022
Předmět: Obhajoba dizertační práce (B90002)
Oponenti: prof. MUDr. Jitka Kuncová, Ph.D.
  doc. RNDr. Ján Bakoš, Ph.D.
 
 
Seznam odborné literatury
1. Abrams, P., Andersson, K. E., Buccafusco, J. J., Chapple, C., de Groat, W. C., Fryer, A. D., Kay, G., Laties, A., Nathanson, N. M., Pasricha, P. J., & Wein, A. J. (2006). Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder. British journal of pharmacology, 148(5), 565–578.https://doi.org/10.1038/sj.bjp.0706780
2. Abrahamson, E. E., & Moore, R. Y. (2001). Suprachiasmatic nucleus in the mouse: retinal innervation, intrinsic organization and efferent projections. Brain research, 916(1-2), 172–191. https://doi.org/10.1016/s0006-8993(01)02890-6
3. Adelman J.P., Clapham D.E., Hibino H., Inanobe A., Jan L.Y., Karschin A., Kubo Y., Kurachi Y., Lazdunski M., Miki T., Nichols C.G., Palmer L.G., Pearson W.L., Sackin H., Seino S., Slesinger P.A., Tucker S. and Vandenberg C.A., (2019). Inwardly rectifying potassium channels (KIR) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). https://doi.org/10.2218/gtopdb/F74/2019.4.
4. Adigun, A. A., Wrench, N., Seidler, F. J., & Slotkin, T. A. (2010). Neonatal dexamethasone treatment leads to alterations in cell signaling cascades controlling hepatic and cardiac function in adulthood. Neurotoxicology and teratology, 32(2), 193–199.https://doi.org/10.1016/j.ntt.2009.10.002
5. Akasu T., Inokuchi H. (2000) Modulation of Synaptic Transmission in the Autonomic Nervous System. In: Kuba K., Higashida H., Brown D.A., Yoshioka T. (eds) Slow Synaptic Responses and Modulation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-66973-9_51
6. Alexander, S. P., Fabbro, D., Kelly, E., Mathie, A., Peters, J. A., Veale, E. L., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., Southan, C., Davies, J. A., Boison, D., Burns, K. E., Dessauer, C., Gertsch, J., Helsby, N. A., Izzo, A. A., Koesling, D., Ostrom, R., … Wong, S. S. (2021). THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. British journal of pharmacology, 178 Suppl 1, S313–S411. https://doi.org/10.1111/bph.
7. Allon, N., Rabinovitz, I., Manistersky, E., Weissman, B. A., & Grauer, E. (2005). Acute and long-lasting cardiac changes following a single whole-body exposure to sarin vapor in rats. Toxicological sciences : an official journal of the Society of Toxicology, 87(2), 385–390.https://doi.org/10.1093/toxsci/kfi263
8. Andres, A. L., Regev, L., Phi, L., Seese, R. R., Chen, Y., Gall, C. M., & Baram, T. Z. (2013). NMDA receptor activation and calpain contribute to disruption of dendritic spines by the stress neuropeptide CRH. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(43), 16945–16960. https://doi.org/10.1523/JNEUROSCI.1445-13.2013
9. Anumonwo, J. M., & Lopatin, A. N. (2010). Cardiac strong inward rectifier potassium channels. Journal of molecular and cellular cardiology, 48(1), 45–54.https://doi.org/10.1016/j.yjmcc.2009.08.013
10. Arraj M, Lemmer B. Circadian rhythms in heart rate, motility, and body temperature of wild-type C57 and eNOS knock-out mice under light-dark, free-run, and after time zone transition. Chronobiol Int. 2006;23(4):795-812. doi: 10.1080/07420520600827111. PMID: 16887749.
11. Aschoff, J. Circadian Rhythms in Man: A self-sustained oscillator with an inherent frequency underlies human 24-hour periodicity, SCIENCE, 11 Jun 1965, Vol 148, Issue 3676•pp. 1427-1432 DOI: 10.1126/science.148.3676.1427
12. Bailer, U. F., & Kaye, W. H. (2003). A review of neuropeptide and neuroendocrine dysregulation in anorexia and bulimia nervosa. Current drug targets. CNS and neurological disorders, 2(1), 53–59. https://doi.org/10.2174/1568007033338689
13. Bao, A. M., Meynen, G., & Swaab, D. F. (2008). The stress system in depression and neurodegeneration: focus on the human hypothalamus. Brain research reviews, 57(2), 531–553. https://doi.org/10.1016/j.brainresrev.2007.04.005
14. Bernard, C. (1865). Introduction à l’étude de la Médecine Expérimentale.. J. B. Baillière et Fils, Paris, English Translation by H. C. Greene, New York, NY: Dover Publications, Inc. 8889.
15. Behar, J., Ganesan, A., Zhang, J., & Yaniv, Y. (2016). The Autonomic Nervous System Regulates the Heart Rate through cAMP-PKA Dependent and Independent Coupled-Clock Pacemaker Cell Mechanisms. Frontiers in physiology, 7, 419. https://doi.org/10.3389/fphys.2016.00419
16. Benes, J., Novakova, M., Rotkova, J., Farar, V., Kvetnansky, R., Riljak, V., & Myslivecek, J. (2012). Beta3 adrenoceptors substitute the role of M(2) muscarinic receptor in coping with cold stress in the heart: evidence from M(2)KO mice. Cellular and molecular neurobiology, 32(5), 859–869. https://doi.org/10.1007/s10571-011-9781-3
17. Berti, C., Zsolnay, V., Shannon, T. R., Fill, M., & Gillespie, D. (2017). Sarcoplasmic reticulum Ca2+, Mg2+, K+, and Cl- concentrations adjust quickly as heart rate changes. Journal of molecular and cellular cardiology, 103, 31–39. https://doi.org/10.1016/j.yjmcc.2016.10.018
18. Billman G. E. (2020). Homeostasis: The Underappreciated and Far Too Often Ignored Central Organizing Principle of Physiology. Frontiers in physiology, 11, 200. https://doi.org/10.3389/fphys.2020.00200
19. Binder M.D., Hirokawa N., Windhorst U. (eds) Encyclopedia of Neuroscience (2009). Springer, Berlin, Heidelberg.https://doi.org/10.1007/978-3-540-29678-2_4479
20. Bisognano, J. D., Weinberger, H. D., Bohlmeyer, T. J., Pende, A., Raynolds, M. V., Sastravaha, A., Roden, R., Asano, K., Blaxall, B. C., Wu, S. C., Communal, C., Singh, K., Colucci, W., Bristow, M. R., & Port, D. J. (2000). Myocardial-directed overexpression of the human beta(1)-adrenergic receptor in transgenic mice. Journal of molecular and cellular cardiology, 32(5), 817–830. https://doi.org/10.1006/jmcc.2000.1123
21. Bissonnette, J. M., Knopp, S. J., Maylie, J., & Thong, T. (2007). Autonomic cardiovascular control in methyl-CpG-binding protein 2 (Mecp2) deficient mice. Autonomic neuroscience : basic & clinical, 136(1-2), 82–89.https://doi.org/10.1016/j.autneu.2007.04.007
22. Boehm, S., & Kubista, H. (2002). Fine tuning of sympathetic transmitter release via ionotropic and metabotropic presynaptic receptors. Pharmacological reviews, 54(1), 43–99. https://doi.org/10.1124/pr.54.1.43
23. Boivin DB, Boudreau P. Impacts of shift work on sleep and circadian rhythms. Pathol Biol (Paris). 2014 Oct;62(5):292-301. doi: 10.1016/j.patbio.2014.08.001. Epub 2014 Sep 20. PMID: 25246026.
24. Brodde, O. E., Broede, A., Daul, A., Kunde, K., & Michel, M. C. (1992). Receptor systems in the non-failing human heart. Basic research in cardiology, 87 Suppl 1, 1–14.https://doi.org/10.1007/978-3-642-72474-9_1
25. Brodde, O. E., Michel, M. C., & Zerkowski, H. R. (1995). Signal transduction mechanisms controlling cardiac contractility and their alterations in chronic heart failure. Cardiovascular research, 30(4), 570–584.
26. Brodde, O. E., & Michel, M. C. (1999). Adrenergic and muscarinic receptors in the human heart. Pharmacological reviews, 51(4), 651–690.
27. Brodde, O. E., Bruck, H., Leineweber, K., & Seyfarth, T. (2001). Presence, distribution and physiological function of adrenergic and muscarinic receptor subtypes in the human heart. Basic research in cardiology, 96(6), 528–538.https://doi.org/10.1007/s003950170003
28. Brodde OE, Leineweber K (2004) Autonomic receptor systems in the failing and aging human heart: similarities and differences. Eur J Pharmacol 500:167–176
29. Brodde, O. E., Bruck, H., & Leineweber, K. (2006). Cardiac adrenoceptors: physiological and pathophysiological relevance. Journal of pharmacological sciences, 100(5), 323–337. https://doi.org/10.1254/jphs.crj06001x
30. Brunson, K. L., Eghbal-Ahmadi, M., Bender, R., Chen, Y., & Baram, T. Z. (2001). Long-term, progressive hippocampal cell loss and dysfunction induced by early-life administration of corticotropin-releasing hormone reproduce the effects of early-life stress. Proceedings of the National Academy of Sciences of the United States of America, 98(15), 8856–8861. https://doi.org/10.1073/pnas.151224898
31. Brunton Paula J. , Russell John A. in Knobil and Neill's Physiology of Reproduction (Fourth Edition), 2015 ISBN 978-0-12-397175-3, Academic Press https://doi.org/10.1016/C2011-1-07288-0
32. Buijs, R. M., & Kalsbeek, A. (2001). Hypothalamic integration of central and peripheral clocks. Nature reviews. Neuroscience, 2(7), 521–526. https://doi.org/10.1038/35081582
33. Burnstock G. (2009). Autonomic neurotransmission: 60 years since sir Henry Dale. Annual review of pharmacology and toxicology, 49, 1–30. https://doi.org/10.1146/annurev.pharmtox.052808.102215
34. Buynitsky, T., & Mostofsky, D. I. (2009). Restraint stress in biobehavioral research: Recent developments. Neuroscience and biobehavioral reviews, 33(7), 1089–1098.https://doi.org/10.1016/j.neubiorev.2009.05.004
35. Bymaster, F. P., Carter, P. A., Zhang, L., Falcone, J. F., Stengel, P. W., Cohen, M. L., Shannon, H. E., Gomeza, J., Wess, J., & Felder, C. C. (2001). Investigations into the physiological role of muscarinic M2 and M4 muscarinic and M4 receptor subtypes using receptor knockout mice. Life sciences, 68(22-23), 2473–2479. https://doi.org/10.1016/s0024-3205(01)01041-4
36. Calvillo, L., Vanoli, E., Andreoli, E., Besana, A., Omodeo, E., Gnecchi, M., Zerbi, P., Vago, G., Busca, G., & Schwartz, P. J. (2011). Vagal stimulation, through its nicotinic action, limits infarct size and the inflammatory response to myocardial ischemia and reperfusion. Journal of cardiovascular pharmacology, 58(5), 500–507. https://doi.org/10.1097/FJC.0b013e31822b7204
37. Cannon, W. B. The Wisdom of the Body. Nature 133, 82 (1934). https://doi.org/10.1038/133082a0
38. Cannon, W. B. (1939). The Wisdom of the Body. New York: WW Norton and Company.
39. Carnevali, L., Bondarenko, E., Sgoifo, A., Walker, F. R., Head, G. A., Lukoshkova, E. V., Day, T. A., & Nalivaiko, E. (2011). Metyrapone and fluoxetine suppress enduring behavioral but not cardiac effects of subchronic stress in rats. American journal of physiology. Regulatory, integrative and comparative physiology, 301(4), R1123–R1131.https://doi.org/10.1152/ajpregu.00273.2011
40. Chan, S., & Debono, M. (2010). Replication of cortisol circadian rhythm: new advances in hydrocortisone replacement therapy. Therapeutic advances in endocrinology and metabolism, 1(3), 129–138.https://doi.org/10.1177/2042018810380214
41. Chatterjee, S., Nam, D., Guo, B., Kim, J. M., Winnier, G. E., Lee, J., Berdeaux, R., Yechoor, V. K., & Ma, K. (2013). Brain and muscle Arnt-like 1 is a key regulator of myogenesis. Journal of cell science, 126(Pt 10), 2213–2224. https://doi.org/10.1242/jcs.12051910.1242/jcs.120519. Epub 2013 Mar 22. PMID: 23525013; PMCID: PMC3672937.
42. Chen, R., Seo, D. O., Bell, E., von Gall, C., & Lee, C. (2008). Strong resetting of the mammalian clock by constant light followed by constant darkness. The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(46), 11839–11847. https://doi.org/10.1523/JNEUROSCI.2191-08.2008
43. Chen, Y., Andres, A. L., Frotscher, M., & Baram, T. Z. (2012). Tuning synaptic transmission in the hippocampus by stress: the CRH system. Frontiers in cellular neuroscience, 6, 13. https://doi.org/10.3389/fncel.2012.00013
44. Chen, Y., Kramár, E. A., Chen, L. Y., Babayan, A. H., Andres, A. L., Gall, C. M., Lynch, G., & Baram, T. Z. (2013). Impairment of synaptic plasticity by the stress mediator CRH involves selective destruction of thin dendritic spines via RhoA signaling. Molecular psychiatry, 18(4), 485–496.https://doi.org/10.1038/mp.2012.17
45. Chen, Y., Molet, J., Lauterborn, J. C., Trieu, B. H., Bolton, J. L., Patterson, K. P., Gall, C. M., Lynch, G., & Baram, T. Z. (2016). Converging, Synergistic Actions of Multiple Stress Hormones Mediate Enduring Memory Impairments after Acute Simultaneous Stresses. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(44), 11295–11307.https://doi.org/10.1523/JNEUROSCI.2542-16.2016
46. Chen, X., Bai, Y., Sun, H., Su, Z., Guo, J., Sun, C., & Du, Z. (2017). Overexpression of M3 Muscarinic Receptor Suppressed Adverse Electrical Remodeling in Hypertrophic Myocardium Via Increasing Repolarizing K+ Currents. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43(3), 915–925. https://doi.org/10.1159/000481642
47. Chocyk, A., Przyborowska, A., Makuch, W., Majcher-Maślanka, I., Dudys, D., & Wędzony, K. (2014). The effects of early-life adversity on fear memories in adolescent rats and their persistence into adulthood. Behavioural brain research, 264, 161–172.https://doi.org/10.1016/j.bbr.2014.01.040
48. Chruscinski, A. J., Rohrer, D. K., Schauble, E., Desai, K. H., Bernstein, D., & Kobilka, B. K. (1999). Targeted disruption of the beta2 adrenergic receptor gene. The Journal of biological chemistry, 274(24), 16694–16700. https://doi.org/10.1074/jbc.274.24.16694
49. Czeisler, C. A., Duffy, J. F., Shanahan, T. L., Brown, E. N., Mitchell, J. F., Rimmer, D. W., Ronda, J. M., Silva, E. J., Allan, J. S., Emens, J. S., Dijk, D. J., & Kronauer, R. E. (1999). Stability, precision, and near-24-hour period of the human circadian pacemaker. Science (New York, N.Y.), 284(5423), 2177–2181.https://doi.org/10.1126/science.284.5423.2177
50. Cole, C. R., Blackstone, E. H., Pashkow, F. J., Snader, C. E., & Lauer, M. S. (1999). Heart-rate recovery immediately after exercise as a predictor of mortality. The New England journal of medicine, 341(18), 1351–1357.https://doi.org/10.1056/NEJM199910283411804
51. Communal, C., & Colucci, W. S. (2005). The control of cardiomyocyte apoptosis via the beta-adrenergic signaling pathways. Archives des maladies du coeur et des vaisseaux, 98(3), 236–241.
52. Contoreggi C. (2015). Corticotropin releasing hormone and imaging, rethinking the stress axis. Nuclear medicine and biology, 42(4), 323–339. https://doi.org/10.1016/j.nucmedbio.2014.11.008
53. Costa G. Sleep deprivation due to shift work. Handb Clin Neurol. 2015;131:437-46. doi: 10.1016/B978-0-444-62627-1.00023-8. PMID: 26563802.
54. Czeisler, C. A., Duffy, J. F., Shanahan, T. L., et al. Stability,precision, and near-24-hour period of the human circadian pace-maker. Science, 1999, 284: 2177–218
55. Davies K. J. (2016). Adaptive homeostasis. Molecular aspects of medicine, 49, 1–7.https://doi.org/10.1016/j.mam.2016.04.007
56. Di Comite, G., Grazia Sabbadini, M., Corti, A., Rovere-Querini, P., & Manfredi, A. A. (2007). Conversation galante: how the immune and the neuroendocrine systems talk to each other. Autoimmunity reviews, 7(1), 23–29. https://doi.org/10.1016/j.autrev.2007.03.004
57. DiFrancesco D. (2010). The role of the funny current in pacemaker activity. Circulation research, 106(3), 434–446.https://doi.org/10.1161/CIRCRESAHA.109.208041
58. Donner, N. C., Siebler, P. H., Johnson, D. T., Villarreal, M. D., Mani, S., Matti, A. J., & Lowry, C. A. (2016). Serotonergic systems in the balance: CRHR1 and CRHR2 differentially control stress-induced serotonin synthesis. Psychoneuroendocrinology, 63, 178–190. https://doi.org/10.1016/j.psyneuen.2015.09.024
59. Drolet, G., & Rivest, S. (2001). Corticotropin-releasing hormone and its receptors; an evaluation at the transcription level in vivo. Peptides, 22(5), 761–767.https://doi.org/10.1016/s0196-9781(01)00389-8
60. Dubowy, C., & Sehgal, A. (2017). Circadian Rhythms and Sleep in Drosophila melanogaster. Genetics, 205(4), 1373–1397. https://doi.org/10.1534/genetics.115.185157
61. Dyavanapalli, J., Dergacheva, O., Wang, X., & Mendelowitz, D. (2016). Parasympathetic Vagal Control of Cardiac Function. Current hypertension reports, 18(3), 22. https://doi.org/10.1007/s11906-016-0630-0
62. Dyavanapalli, J., Hora, A. J., Escobar, J. B., Schloen, J., Dwyer, M. K., Rodriguez, J., Spurney, C. F., Kay, M. W., & Mendelowitz, D. (2020). Chemogenetic activation of intracardiac cholinergic neurons improves cardiac function in pressure overload-induced heart failure. American journal of physiology. Heart and circulatory physiology, 319(1), H3–H12. https://doi.org/10.1152/ajpheart.00150.2020
63. Ebling, F. J., Lincoln, G. A., Wollnik, F., & Anderson, N. (1988). Effects of constant darkness and constant light on circadian organization and reproductive responses in the ram. Journal of biological rhythms, 3(4), 365–384.https://doi.org/10.1177/074873048800300406
64. Ecker, P. M., Lin, C. C., Powers, J., Kobilka, B. K., Dubin, A. M., & Bernstein, D. (2006). Effect of targeted deletions of beta1- and beta2-adrenergic-receptor subtypes on heart rate variability. American journal of physiology. Heart and circulatory physiology, 290(1), H192–H199. https://doi.org/10.1152/ajpheart.00032.2005
65. Eglen R. M. (2006). Muscarinic receptor subtypes in neuronal and non-neuronal cholinergic function. Autonomic & autacoid pharmacology, 26(3), 219–233. https://doi.org/10.1111/j.1474-8673.2006.00368.x
66. Ehlen, J. C., Brager, A. J., Baggs, J., Pinckney, L., Gray, C. L., DeBruyne, J. P., Esser, K. A., Takahashi, J. S., & Paul, K. N. (2017). Bmal1 function in skeletal muscle regulates sleep. eLife, 6, e26557. https://doi.org/10.7554/eLife.26557
67. El-Armouche, A., Gocht, F., Jaeckel, E., Wittköpper, K., Peeck, M., & Eschenhagen, T. (2007). Long-term beta-adrenergic stimulation leads to downregulation of protein phosphatase inhibitor-1 in the heart. European journal of heart failure, 9(11), 1077–1080. https://doi.org/10.1016/j.ejheart.2007.09.006
68. Fasano C, Niel JP. The mammalian sympathetic prevertebral ganglia: models for the study of neuronal networks and basic neuronal properties. Auton Neurosci. 2009 Oct 5;150(1-2):8-20. doi: 10.1016/j.autneu.2009.06.006. Epub 2009 Jul 5. PMID: 19581130.
69. Fernandez, M. P., Pettibone, H. L., Bogart, J. T., Roell, C. J., Davey, C. E., Pranevicius, A., Huynh, K. V., Lennox, S. M., Kostadinov, B. S., & Shafer, O. T. (2020). Sites of Circadian Clock Neuron Plasticity Mediate Sensory Integration and Entrainment. Current biology : CB, 30(12), 2225–2237.e5. https://doi.org/10.1016/j.cub.2020.04.025
70. Finsterwald, C., & Alberini, C. M. (2014). Stress and glucocorticoid receptor-dependent mechanisms in long-term memory: from adaptive responses to psychopathologies. Neurobiology of learning and memory, 112, 17–29.https://doi.org/10.1016/j.nlm.2013.09.017
71. Fisher, J. T., Vincent, S. G., Gomeza, J., Yamada, M., & Wess, J. (2004). Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 18(6), 711–713. https://doi.org/10.1096/fj.03-0648fje
72. Focke, C., & Iremonger, K. J. (2020). Rhythmicity matters: Circadian and ultradian patterns of HPA axis activity. Molecular and cellular endocrinology, 501, 110652. https://doi.org/10.1016/j.mce.2019.110652
73. Foulkes, N. S., Duval, G., & Sassone-Corsi, P. (1996). Adaptive inducibility of CREM as transcriptional memory of circadian rhythms. Nature, 381(6577), 83–85. https://doi.org/10.1038/381083a0
74. Frank, K., & Kranias, E. G. (2000). Phospholamban and cardiac contractility. Annals of medicine, 32(8), 572–578.https://doi.org/10.3109/07853890008998837
75. Fryer, A. D., & Jacoby, D. B. (1998). Muscarinic receptors and control of airway smooth muscle. American journal of respiratory and critical care medicine, 158(5 Pt 3), S154–S160.https://doi.org/10.1164/ajrccm.158.supplement_2.13tac120
76. Fu, L., Pelicano, H., Liu, J., Huang, P., & Lee, C. (2002). The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell, 111(1), 41–50. https://doi.org/10.1016/s0092-8674(02)00961-3
77. Fuge, P., Aust, S., Fan, Y., Weigand, A., Gärtner, M., Feeser, M., Bajbouj, M., & Grimm, S. (2014). Interaction of early life stress and corticotropin-releasing hormone receptor gene: effects on working memory. Biological psychiatry, 76(11), 888–894.https://doi.org/10.1016/j.biopsych.2014.04.016
78. Füzesi, T., Daviu, N., Wamsteeker Cusulin, J. I., Bonin, R. P., & Bains, J. S. (2016). Hypothalamic CRH neurons orchestrate complex behaviours after stress. Nature communications, 7, 11937. https://doi.org/10.1038/ncomms11937
79. Gallagher, J. P., Orozco-Cabal, L. F., Liu, J., & Shinnick-Gallagher, P. (2008). Synaptic physiology of central CRH system. European journal of pharmacology, 583(2-3), 215–225.https://doi.org/10.1016/j.ejphar.2007.11.075
80. Gauthier, C., Leblais, V., Kobzik, L., Trochu, J. N., Khandoudi, N., Bril, A., Balligand, J. L., & Le Marec, H. (1998). The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle. The Journal of clinical investigation, 102(7), 1377–1384.https://doi.org/10.1172/JCI2191
81. Gauthier, C., Leblais, V., Moniotte, S., Langin, D., & Balligand, J. L. (2000). The negative inotropic action of catecholamines: role of beta3-adrenoceptors. Canadian journal of physiology and pharmacology, 78(9), 681–690.
82. Gerstner, J. R., & Yin, J. C. (2010). Circadian rhythms and memory formation. Nature reviews. Neuroscience, 11(8), 577–588. https://doi.org/10.1038/nrn2881
83. Gibbs D. M. (1986). Vasopressin and oxytocin: hypothalamic modulators of the stress response: a review. Psychoneuroendocrinology, 11(2), 131–139.https://doi.org/10.1016/0306-4530(86)90048-x
84. Goldstein D. S. (1995). Stress, catecholamines, and cardiovascular disease Oxford University Press, 1995
85. Goldstein D. S. (2003). Catecholamines and stress. Endocrine regulations, 37(2), 69–80.
86. Goldstein D. S. (2010). Adrenal responses to stress. Cellular and molecular neurobiology, 30(8), 1433–1440. https://doi.org/10.1007/s10571-010-9606-9
87. Gomeza, J., Shannon, H., Kostenis, E., Felder, C., Zhang, L., Brodkin, J., Grinberg, A., Sheng, H., & Wess, J. (1999). Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice. Proceedings of the National Academy of Sciences of the United States of America, 96(4), 1692–1697. https://doi.org/10.1073/pnas.96.4.1692
88. Gordan, R., Gwathmey, J. K., & Xie, L. H. (2015). Autonomic and endocrine control of cardiovascular function. World journal of cardiology, 7(4), 204–214. https://doi.org/10.4330/wjc.v7.i4.204
89. Grammatopoulos, D. K., Randeva, H. S., Levine, M. A., Kanellopoulou, K. A., & Hillhouse, E. W. (2001). Rat cerebral cortex corticotropin-releasing hormone receptors: evidence for receptor coupling to multiple G-proteins. Journal of neurochemistry, 76(2), 509–519. https://doi.org/10.1046/j.1471-4159.2001.00067.x
90. Grimm, S., Gärtner, M., Fuge, P., Fan, Y., Weigand, A., Feeser, M., Aust, S., Heekeren, H. R., Jacobs, A., Heuser, I., & Bajbouj, M. (2015). Variation in the corticotropin-releasing hormone receptor 1 (CRHR1) gene modulates age effects on working memory. Journal of psychiatric research, 61, 57–63. https://doi.org/10.1016/j.jpsychires.2014.12.001
91. Groeneweg, F. L., Karst, H., de Kloet, E. R., & Joëls, M. (2011). Rapid non-genomic effects of corticosteroids and their role in the central stress response. The Journal of endocrinology, 209(2), 153–167.https://doi.org/10.1530/JOE-10-0472
92. Grouzmann, E., Cavadas, C., Grand, D., Moratel, M., Aubert, J. F., Brunner, H. R., & Mazzolai, L. (2003). Blood sampling methodology is crucial for precise measurement of plasma catecholamines concentrations in mice. Pflugers Archiv : European journal of physiology, 447(2), 254–258. https://doi.org/10.1007/s00424-003-1140-x
93. Guo, H., Brewer, J. M., Lehman, M. N., & Bittman, E. L. (2006). Suprachiasmatic regulation of circadian rhythms of gene expression in hamster peripheral organs: effects of transplanting the pacemaker. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(24), 6406–6412. https://doi.org/10.1523/JNEUROSCI.4676-05.2006
94. Gupta, D., & Morley, J. E. (2014). Hypothalamic-pituitary-adrenal (HPA) axis and aging. Comprehensive Physiology, 4(4), 1495–1510.https://doi.org/10.1002/cphy.c130049
95. Günther, B., Morgado, E., & Jiménez, R. F. (2003). Homeostasis and heterostasis: from invariant to dimensionless numbers. Biological research, 36(2), 211–221.https://doi.org/10.4067/s0716-97602003000200011
96. Hafner, M., Koeppl, H., & Gonze, D. (2012). Effect of network architecture on synchronization and entrainment properties of the circadian oscillations in the suprachiasmatic nucleus. PLoS computational biology, 8(3), e1002419. https://doi.org/10.1371/journal.pcbi.1002419
97. Harding, S. E. (1997). Lack of evidence for beta3-adrenoceptor modulation of contractile function in human ventricular myocytes. Circulation, 96(8S).
98. Hata, T., Itoh, E., Funakami, Y., Ishida, K., & Uchida, S. (2001). Blood pressure and heart rate are increased by AF-DX 116, a selective M2 antagonist, in autonomic imbalanced and hypotensive rats caused by repeated cold stress. Japanese journal of pharmacology, 85(3), 313–321. https://doi.org/10.1254/jjp.85.313
99. Harfmann, B. D., Schroder, E. A., Kachman, M. T., Hodge, B. A., Zhang, X., & Esser, K. A. (2016). Muscle-specific loss of Bmal1 leads to disrupted tissue glucose metabolism and systemic glucose homeostasis. Skeletal muscle, 6, 12. https://doi.org/10.1186/s13395-016-0082-x
100. Harper, D. G., Tornatzky, W., & Miczek, K. A. (1996). Stress induced disorganization of circadian and ultradian rhythms: comparisons of effects of surgery and social stress. Physiology & behavior, 59(3), 409–419. https://doi.org/10.1016/0031-9384(95)02012-8
101. Henry, J. P., Liu, Y. Y., Nadra, W. E., Qian, C. G., Mormede, P., Lemaire, V., Ely, D., & Hendley, E. D. (1993). Psychosocial stress can induce chronic hypertension in normotensive strains of rats. Hypertension (Dallas, Tex. : 1979), 21(5), 714–723. https://doi.org/10.1161/01.hyp.21.5.714
102. Henry in Laragh, J. H., & Brenner, B. M. (1995). Hypertension: Pathophysiology, diagnosis, and management. New York: Raven Press.
103. Herring, N., & Paterson, D. J. (2009). Neuromodulators of peripheral cardiac sympatho-vagal balance. Experimental physiology, 94(1), 46–53. https://doi.org/10.1113/expphysiol.2008.044776
104. Hoffmann, C., Leitz, M. R., Oberdorf-Maass, S., Lohse, M. J., & Klotz, K. N. (2004). Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedeberg's archives of pharmacology, 369(2), 151–159. https://doi.org/10.1007/s00210-003-0860-y
105. Holsboer, F., & Ising, M. (2008). Central CRH system in depression and anxiety--evidence from clinical studies with CRH1 receptor antagonists. European journal of pharmacology, 583(2-3), 350–357. https://doi.org/10.1016/j.ejphar.2007.12.032
106. Horowitz M. (2002). From molecular and cellular to integrative heat defense during exposure to chronic heat. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 131(3), 475–483. https://doi.org/10.1016/s1095-6433(01)00500-1
107. Höschl, C., Hajek, T. Hippocampal damage mediated by corticosteroids — a neuropsychiatric research challenge. Eur Arch Psychiatry Clin Nuerosci 251, 81–88 (2001).https://doi.org/10.1007/BF03035134
108. Huang, C. J., Webb, H. E., Zourdos, M. C., & Acevedo, E. O. (2013). Cardiovascular reactivity, stress, and physical activity. Frontiers in physiology, 4, 314.https://doi.org/10.3389/fphys.2013.00314
109. Hupalo, S., Bryce, C. A., Bangasser, D. A., Berridge, C. W., Valentino, R. J., & Floresco, S. B. (2019). Corticotropin-Releasing Factor (CRF) circuit modulation of cognition and motivation. Neuroscience and biobehavioral reviews, 103, 50–59.https://doi.org/10.1016/j.neubiorev.2019.06.010
110. Illnerova H, Sumova A (2009), Vnitřní časový systém,Interní Med. 2008; 10(7): 350-352
111. Ishii M, Kurachi Y. Muscarinic acetylcholine receptors. Curr Pharm Des. 2006;12(28):3573-3581. doi:10.2174/138161206778522056
112. James G. D. (2019). The Adaptive Value and Clinical Significance of Allostatic Blood Pressure Variation. Current hypertension reviews, 15(2), 93–104.https://doi.org/10.2174/1573402115666190301144316
113. Joëls M. (2018). Corticosteroids and the brain. The Journal of endocrinology, 238(3), R121–R130. https://doi.org/10.1530/JOE-18-0226
114. Jones, J.R., Chaturvedi, S., Granados-Fuentes, D. et al. Circadian neurons in the paraventricular nucleus entrain and sustain daily rhythms in glucocorticoids. Nat Commun 12, 5763 (2021). https://doi.org/10.1038/s41467-021-25959-9
115. Joung, B., Ogawa, M., Lin, S. F., & Chen, P. S. (2009). The calcium and voltage clocks in sinoatrial node automaticity. Korean circulation journal, 39(6), 217–222. https://doi.org/10.4070/kcj.2009.39.6.217
116. Kagias, K., Nehammer, C., & Pocock, R. (2012). Neuronal responses to physiological stress. Frontiers in genetics, 3, 222. https://doi.org/10.3389/fgene.2012.00222
117. Kantermann, T., & Eastman, C. I. (2018). Circadian phase, circadian period and chronotype are reproducible over months. Chronobiology international, 35(2), 280–288. https://doi.org/10.1080/07420528.2017.1400979
118. Kamp, T. J., & Hell, J. W. (2000). Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase C. Circulation research, 87(12), 1095–1102.https://doi.org/10.1161/01.res.87.12.1095
119. Karalis, K., Muglia, L. J., Bae, D., Hilderbrand, H., & Majzoub, J. A. (1997). CRH and the immune system. Journal of neuroimmunology, 72(2), 131–136. https://doi.org/10.1016/s0165-5728(96)00178-6
120. Karst, H., den Boon, F. S., Vervoort, N., Adrian, M., Kapitein, L. C., & Joëls, M. (2022). Non-genomic steroid signaling through the mineralocorticoid receptor: Involvement of a membrane-associated receptor?. Molecular and cellular endocrinology, 541, 111501. https://doi.org/10.1016/j.mce.2021.111501
121. Kastin, Abba J. Handbook of Biologically Active Peptides, Academic Press,2006, Pages 655-662 https://doi.org/10.1016/B978-012369442-3/50095-7
122. Kay, M. W., Jain, V., Panjrath, G., & Mendelowitz, D. (2022). Targeting Parasympathetic Activity to Improve Autonomic Tone and Clinical Outcomes. Physiology (Bethesda, Md.), 37(1), 39–45. https://doi.org/10.1152/physiol.00023.2021
123. Kelleher, F. C., Rao, A., & Maguire, A. (2014). Circadian molecular clocks and cancer. Cancer letters, 342(1), 9–18.https://doi.org/10.1016/j.canlet.2013.09.040
124. Kim SM, Huang Y, Qin Y, Mizel D, Schnermann J, Briggs JP. Persistence of circadian variation in arterial blood pressure in beta1/beta2-adrenergic receptor-deficient mice. Am J Physiol Regul Integr Comp Physiol. 2008 May;294(5):R1427-34. doi: 10.1152/ajpregu.00074.2008. Epub 2008 Feb 27. PMID: 18305025; PMCID: PMC2386676.
125. Kim, M. H., & Leem, Y. H. (2014). Chronic exercise improves repeated restraint stress-induced anxiety and depression through 5HT1A receptor and cAMP signaling in hippocampus. Journal of exercise nutrition & biochemistry, 18(1), 97–104.https://doi.org/10.5717/jenb.2014.18.1.97
126. Kim, M. S., Maltsev, A. V., Monfredi, O., Maltseva, L. A., Wirth, A., Florio, M. C., Tsutsui, K., Riordon, D. R., Parsons, S. P., Tagirova, S., Ziman, B. D., Stern, M. D., Lakatta, E. G., & Maltsev, V. A. (2018). Heterogeneity of calcium clock functions in dormant, dysrhythmically and rhythmically firing single pacemaker cells isolated from SA node. Cell calcium, 74, 168–179. https://doi.org/10.1016/j.ceca.2018.07.002
127. Kimura, T. , Mukaiyama, O. & Satoh, S. (1992). Journal of Cardiovascular Pharmacology, 19 (3), 382-386.
128. Kiriazis, H., Wang, K., Xu, Q., Gao, X. M., Ming, Z., Su, Y., Moore, X. L., Lambert, G., Gibbs, M. E., Dart, A. M., & Du, X. J. (2008). Knockout of beta(1)- and beta(2)-adrenoceptors attenuates pressure overload-induced cardiac hypertrophy and fibrosis. British journal of pharmacology, 153(4), 684–692. https://doi.org/10.1038/sj.bjp.0707622
129. Kitazawa, T., Asakawa, K., Nakamura, T., Teraoka, H., Unno, T., Komori, S., Yamada, M., & Wess, J. (2009). M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice. The Journal of pharmacology and experimental therapeutics, 330(2), 487–493.https://doi.org/10.1124/jpet.109.153304
130. Kitazawa T. et al. (2016) Regulation of Heart Contractility by M2 and M3 Muscarinic Receptors: Functional Studies Using Muscarinic Receptor Knockout Mouse. In: Myslivecek J., Jakubik J. (eds) Muscarinic Receptor: From Structure to Animal Models. Neuromethods, vol 107. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2858-3_13
131. Kittnar O., Mlček M., Atlas fyziologických regulací, Grada Publishing, a.s., 2009, s. 100
132. Klabunde, R.E.,Cardiovascular Physiology Concepts, New Third Edition, Published by Wolters Kluwer, 2021 ISBN-13: 9781975150075
133. Kloet de, E. R. (2003). Hormones, brain and stress. Endocrine regulations, 37(2), 51–68.
134. Kloet,de E. R., Karst, H., & Joëls, M. (2008). Corticosteroid hormones in the central stress response: quick-and-slow. Frontiers in neuroendocrinology, 29(2), 268–272. https://doi.org/10.1016/j.yfrne.2007.10.002
135. Kloet de, E. R., & Joëls, M. (2017). Brain mineralocorticoid receptor function in control of salt balance and stress-adaptation. Physiology & behavior, 178, 13–20. https://doi.org/10.1016/j.physbeh.2016.12.045
136. Knutsson A. Health disorders of shift workers. Occup Med (Lond). 2003 Mar;53(2):103-8. doi: 10.1093/occmed/kqg048. PMID: 12637594.
137. Kuwahara, M., Tsujino, Y., Tsubone, H., Kumagai, E., Tsutsumi, H., & Tanigawa, M. (2004). Effects of pair housing on diurnal rhythms of heart rate and heart rate variability in miniature swine. Experimental animals, 53(4), 303–309.https://doi.org/10.1538/expanim.53.303
138. Krahn, D. D., Gosnell, B. A., Levine, A. S., & Morley, J. E. (1988). Behavioral effects of corticotropin-releasing factor: localization and characterization of central effects. Brain research, 443(1-2), 63–69. https://doi.org/10.1016/0006-8993(88)91598-3
139. Kvetnanský, R., Pacák, K., Fukuhara, K., Viskupic, E., Hiremagalur, B., Nankova, B., Goldstein, D. S., Sabban, E. L., & Kopin, I. J. (1995). Sympathoadrenal system in stress. Interaction with the hypothalamic-pituitary-adrenocortical system. Annals of the New York Academy of Sciences, 771, 131–158. https://doi.org/10.1111/j.1749-6632.1995.tb44676.x
140. Kvetnansky, R., Sabban, E. L., & Palkovits, M. (2009). Catecholaminergic systems in stress: structural and molecular genetic approaches. Physiological reviews, 89(2), 535–606. https://doi.org/10.1152/physrev.00042.2006
141. Kong, S. S., Liu, J. J., Yu, X. J., Lu, Y., & Zang, W. J. (2012). Protection against ischemia-induced oxidative stress conferred by vagal stimulation in the rat heart: involvement of the AMPK-PKC pathway. International journal of molecular sciences, 13(11), 14311–14325. https://doi.org/10.3390/ijms131114311
142. LaCroix, C., Freeling, J., Giles, A., Wess, J., & Li, Y. F. (2008). Deficiency of M2 muscarinic acetylcholine receptors increases susceptibility of ventricular function to chronic adrenergic stress. American journal of physiology. Heart and circulatory physiology, 294(2), H810–H820.https://doi.org/10.1152/ajpheart.00724.2007
143. Lakatta, E. G., Maltsev, V. A., & Vinogradova, T. M. (2010). A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker. Circulation research, 106(4), 659–673.https://doi.org/10.1161/CIRCRESAHA.109.206078
144. Laukova, M., Tillinger, A., Novakova, M., Krizanova, O., Kvetnansky, R., & Myslivecek, J. (2014). Repeated immobilization stress increases expression of β3 -adrenoceptor in the left ventricle and atrium of the rat heart. Stress and health : journal of the International Society for the Investigation of Stress, 30(4), 301–309. https://doi.org/10.1002/smi.2515
145. Lazarus, R. S., Averill, J. R., & Opton, E. M. (1974). The psychology of coping: Issues of research and assessment. Coping and adaptation, 249-315.
146. Lee, S., Grafweg, S., Schneider, T., Jimenez, M., Giacobino, J. P., Ghanem, A., Tiemann, K., Bloch, W., Müller-Ehmsen, J., Schwinger, R. H., & Brixius, K. (2010). Total beta-adrenoceptor deficiency results in cardiac hypotrophy and negative inotropy. Physiological research, 59(5), 679–689. https://doi.org/10.33549/physiolres.931851
147. Lee, D. Y., Kim, E., & Choi, M. H. (2015, April 30). Technical and clinical aspects
of cortisol as a biochemical marker of chronic stress. BMB Reports. Korean Society for Biochemistry and Molecular Biology - BMB Reports. https://doi.org/10.5483/bmbrep.2015.48.4.275
148. Lemaire, V., & Mormède, P. (1995). Telemetered recording of blood pressure and heart rate in different strains of rats during chronic social stress. Physiology & behavior, 58(6), 1181–1188. https://doi.org/10.1016/0031-9384(95)02064-0
149. Lezcano, N., Mariángelo, J., Vittone, L., Wehrens, X., Said, M., & Mundiña-Weilenmann, C. (2018). Early effects of Epac depend on the fine-tuning of the sarcoplasmic reticulum Ca2+ handling in cardiomyocytes. Journal of molecular and cellular cardiology, 114, 1–9. https://doi.org/10.1016/j.yjmcc.2017.10.005
150. Li, D. L., Liu, B. H., Sun, L., Zhao, M., He, X., Yu, X. J., & Zang, W. J. (2010). Alterations of muscarinic acetylcholine receptors-2, 4 and α7-nicotinic acetylcholine receptor expression after ischaemia / reperfusion in the rat isolated heart. Clinical and experimental pharmacology & physiology, 37(12), 1114–1119. https://doi.org/10.1111/j.1440-1681.2010.05448.x
151. Li, D. L., Liu, J. J., Liu, B. H., Hu, H., Sun, L., Miao, Y., Xu, H. F., Yu, X. J., Ma, X., Ren, J., & Zang, W. J. (2011). Acetylcholine inhibits hypoxia-induced tumor necrosis factor-α production via regulation of MAPKs phosphorylation in cardiomyocytes. Journal of cellular physiology, 226(4), 1052–1059. https://doi.org/10.1002/jcp.22424
152. Lin, L. L., Huang, H. C., Juan, H. F., & 2014 Taida Cancer Systems Biology Study Group (2015). Circadian systems biology in Metazoa. Briefings in bioinformatics, 16(6), 1008–1024.https://doi.org/10.1093/bib/bbv006
153. Looser, R. R., Metzenthin, P., Helfricht, S., Kudielka, B. M., Loerbroks, A., Thayer, J. F., & Fischer, J. E. (2010). Cortisol is significantly correlated with cardiovascular responses during high levels of stress in critical care personnel. Psychosomatic medicine, 72(3), 281–289. https://doi.org/10.1097/PSY.0b013e3181d35065
154. Lovejoy, D. A., Chang, B. S., Lovejoy, N. R., & del Castillo, J. (2014). Molecular evolution of GPCRs: CRH/CRH receptors. Journal of molecular endocrinology, 52(3), T43–T60. https://doi.org/10.1530/JME-13-0238
155. MacDonald, E. A., Rose, R. A., & Quinn, T. A. (2020). Neurohumoral Control of Sinoatrial Node Activity and Heart Rate: Insight From Experimental Models and Findings From Humans. Frontiers in physiology, 11, 170. https://doi.org/10.3389/fphys.2020.00170
156. Madwed, J. B., & Cohen, R. J. (1991). Heart rate response to hemorrhage-induced 0.05-Hz oscillations in arterial pressure in conscious dogs. The American journal of physiology, 260(4 Pt 2), H1248–H1253. https://doi.org/10.1152/ajpheart.1991.260.4.H1248
157. Makino, S., Tanaka, Y., Nazarloo, H. P., Noguchi, T., Nishimura, K., & Hashimoto, K. (2005). Expression of type 1 corticotropin-releasing hormone (CRH) receptor mRNA in the hypothalamic paraventricular nucleus following restraint stress in CRH-deficient mice. Brain research, 1048(1-2), 131–137. https://doi.org/10.1016/j.brainres.2005.04.065
158. Manfredini, R., Salmi, R., Cappadona, R., Signani, F., Basili, S., & Katsiki, N. (2017). Sex and Circadian Periodicity of Cardiovascular Diseases: Are Women Sufficiently Represented in Chronobiological Studies?. Heart failure clinics, 13(4), 719–738.https://doi.org/10.1016/j.hfc.2017.05.008
159. Maras, P. M., & Baram, T. Z. (2012). Sculpting the hippocampus from within: stress, spines, and CRH. Trends in neurosciences, 35(5), 315–324. https://doi.org/10.1016/j.tins.2012.01.005
160. Manolis, A. A., Manolis, T. A., Apostolopoulos, E. J., Apostolaki, N. E., Melita, H., & Manolis, A. S. (2021). The role of the autonomic nervous system in cardiac arrhythmias: The neuro-cardiac axis, more foe than friend?. Trends in cardiovascular medicine, 31(5), 290–302. https://doi.org/10.1016/j.tcm.2020.04.011
161. Mariotti S, Beck-Peccoz P. Physiology of the Hypothalamic-Pituitary-Thyroid Axis. [Updated 2021 Apr 20]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from:https://www.ncbi.nlm.nih.gov/books/NBK278958/
162. Mastitskaya, S., Marina, N., Gourine, A., Gilbey, M. P., Spyer, K. M., Teschemacher, A. G., Kasparov, S., Trapp, S., Ackland, G. L., & Gourine, A. V. (2012). Cardioprotection evoked by remote ischaemic preconditioning is critically dependent on the activity of vagal pre-ganglionic neurones. Cardiovascular research, 95(4), 487–494.https://doi.org/10.1093/cvr/cvs212
163. Mastorakos, G., & Ilias, I. (2003). Maternal and fetal hypothalamic-pituitary-adrenal axes during pregnancy and postpartum. Annals of the New York Academy of Sciences, 997, 136–149. https://doi.org/10.1196/annals.1290.016
164. McEwen B. S. (1998). Stress, adaptation, and disease. Allostasis and allostatic load. Annals of the New York Academy of Sciences, 840, 33–44. https://doi.org/10.1111/j.1749-6632.1998.tb09546.x
165. McEwen, B. S., & Sapolsky, R. M. (1995). Stress and cognitive function. Current opinion in neurobiology, 5(2), 205–216. https://doi.org/10.1016/0959-4388(95)80028-x
166. McEwen, B. S., & Wingfield, J. C. (2003). The concept of allostasis in biology and biomedicine. Hormones and behavior, 43(1), 2–15. https://doi.org/10.1016/s0018-506x(02)00024-7
167. McEwen, B. S., & Wingfield, J. C. (2010). What is in a name? Integrating homeostasis, allostasis and stress. Hormones and behavior, 57(2), 105–111. https://doi.org/10.1016/j.yhbeh.2009.09.011
168. McEwen, B. S., Bowles, N. P., Gray, J. D., Hill, M. N., Hunter, R. G., Karatsoreos, I. N., & Nasca, C. (2015). Mechanisms of stress in the brain. Nature neuroscience, 18(10), 1353–1363. https://doi.org/10.1038/nn.4086
169. Meerlo, P., Sgoifo, A., De Boer, S. F., & Koolhaas, J. M. (1999). Long-lasting consequences of a social conflict in rats: behavior during the interaction predicts subsequent changes in daily rhythms of heart rate, temperature, and activity. Behavioral neuroscience, 113(6), 1283–1290. https://doi.org/10.1037//0735-7044.113.6.1283
170. Meerlo, P., Sgoifo, A., & Turek, F. W. (2002). The effects of social defeat and other stressors on the expression of circadian rhythms. Stress (Amsterdam, Netherlands), 5(1), 15–22. https://doi.org/10.1080/102538902900012323
171. Michel, Martin & Michel-Reher, Martina & Hein, Peter. (2020). A Systematic Review of Inverse Agonism at Adrenoceptor Subtypes. Cells. 9. 1923. 10.3390/cells9091923.
172. Miller W. L. (2018). The Hypothalamic-Pituitary-Adrenal Axis: A Brief History. Hormone research in paediatrics, 89(4), 212–223. https://doi.org/10.1159/000487755
173. Mioni, C., Bazzani, C., Giuliani, D., Altavilla, D., Leone, S., Ferrari, A., Minutoli, L., Bitto, A., Marini, H., Zaffe, D., Botticelli, A. R., Iannone, A., Tomasi, A., Bigiani, A., Bertolini, A., Squadrito, F., & Guarini, S. (2005). Activation of an efferent cholinergic pathway produces strong protection against myocardial ischemia/reperfusion injury in rats. Critical care medicine, 33(11), 2621–2628. https://doi.org/10.1097/01.ccm.0000186762.05301.13
174. Modell H, Cliff W, Michael J, McFarland J, Wenderoth MP, Wright A. A physiologist's view of homeostasis. Adv Physiol Educ. 2015;39(4):259-266. doi:10.1152/advan.00107.2015
175. Mohawk, J. A., Green, C. B., & Takahashi, J. S. (2012). Central and peripheral circadian clocks in mammals. Annual review of neuroscience, 35, 445–462.https://doi.org/10.1146/annurev-neuro-060909-153128
176. Muglia, L., Jacobson, L., Dikkes, P., & Majzoub, J. A. (1995). Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature, 373(6513), 427–432. https://doi.org/10.1038/373427a0
177. Myslivecek, J. (2015). The basis of the stress reaction. Current Science, 109(4), 716–726. http://www.jstor.org/stable/24905732
178. Myslivecek Jaromir,Novakova Martina,Klein Martin, “ Receptor Subtype Abundance as a Tool for Effective Intracellular Signalling”, Cardiovascular & Hematological Disorders-Drug Targets 2008; 8(1) https://doi.org/10.2174/187152908783884939
179. Myslivecek, J., Rícný, J., Palkovits, M., & Kvetnanský, R. (2004). The effects of short-term immobilization stress on muscarinic receptors, beta-adrenoceptors, and adenylyl cyclase in different heart regions. Annals of the New York Academy of Sciences, 1018, 315–322. https://doi.org/10.1196/annals.1296.038
180. Myslivecek, J., Tillinger, A., Novakova, M., & Kvetnanský, R. (2008). Regulation of adrenoceptor and muscarinic receptor gene expression after single and repeated stress. Annals of the New York Academy of Sciences, 1148, 367–376. https://doi.org/10.1196/annals.1410.028
181. Mysliveček, Jaromír (2009): Základy neurověd, Nakladatel: Triton EAN: 9788073870881 ISBN: 978-80-7387-088-1
182. Myslivecek, J., & Trojan, S. (2003). Regulation of adrenoceptors and muscarinic receptors in the heart. General physiology and biophysics, 22(1), 3–14.
183. Nezi, M., Mastorakos, G., & Mouslech, Z. (2015). Corticotropin Releasing Hormone And The Immune/Inflammatory Response. In K. R. Feingold (Eds.) et. al., Endotext. MDText.com, Inc.
184. Ngampramuan, S., Baumert, M., Beig, M. I., Kotchabhakdi, N., & Nalivaiko, E. (2008). Activation of 5-HT(1A) receptors attenuates tachycardia induced by restraint stress in rats. American journal of physiology. Regulatory, integrative and comparative physiology, 294(1), R132–R141. https://doi.org/10.1152/ajpregu.00464.2007
185. Nishi, M., Horii-Hayashi, N., & Sasagawa, T. (2014). Effects of early life adverse experiences on the brain: implications from maternal separation models in rodents. Frontiers in neuroscience, 8, 166. https://doi.org/10.3389/fnins.2014.00166
186. Novak, A., Lorber, A., Itskovitz-Eldor, J., & Binah, O. (2012). Modeling Catecholaminergic Polymorphic Ventricular Tachycardia using Induced Pluripotent Stem Cell-derived Cardiomyocytes. Rambam Maimonides medical journal, 3(3), e0015. https://doi.org/10.5041/RMMJ.10086
187. Ohta H, Yamazaki S, McMahon DG. Constant light desynchronizes mammalian clock neurons. Nat Neurosci. 2005 Mar;8(3):267-9. doi: 10.1038/nn1395. Epub 2005 Jan 30. PMID: 15746913.
188. Ondicova, K., & Mravec, B. (2010). Multilevel interactions between the sympathetic and parasympathetic nervous systems: a minireview. Endocrine regulations, 44(2), 69–75. https://doi.org/10.4149/endo_2010_02_69
189. Okuliarova, M., Rumanova, V. S., Stebelova, K., & Zeman, M. (2020). Dim Light at Night Disturbs Molecular Pathways of Lipid Metabolism. International journal of molecular sciences, 21(18), 6919. https://doi.org/10.3390/ijms21186919
190. Orozco-Cabal, L., Pollandt, S., Liu, J., Shinnick-Gallagher, P., & Gallagher, J. P. (2006). Regulation of synaptic transmission by CRF receptors. Reviews in the neurosciences, 17(3), 279–307. https://doi.org/10.1515/revneuro.2006.17.3.279
191. Quaedflieg, C., & Schwabe, L. (2018). Memory dynamics under stress. Memory (Hove, England), 26(3), 364–376. https://doi.org/10.1080/09658211.2017.1338299
192. Pacák, K., & Palkovits, M. (2001). Stressor specificity of central neuroendocrine responses: implications for stress-related disorders. Endocrine reviews, 22(4), 502–548. https://doi.org/10.1210/edrv.22.4.0436
193. Palkovits, M., Baffi, J. S., & Pacak, K. (1999). The role of ascending neuronal pathways in stress-induced release of noradrenaline in the hypothalamic paraventricular nucleus of rats. Journal of neuroendocrinology, 11(7), 529–539.https://doi.org/10.1046/j.1365-2826.1999.00365.x
194. Pan, Z., Guo, Y., Qi, H., Fan, K., Wang, S., Zhao, H., Fan, Y., Xie, J., Guo, F., Hou, Y., Wang, N., Huo, R., Zhang, Y., Liu, Y., & Du, Z. (2012). M3 subtype of muscarinic acetylcholine receptor promotes cardioprotection via the suppression of miR-376b-5p. PloS one, 7(3), e32571. https://doi.org/10.1371/journal.pone.0032571
195. Pei J, Li N, Chen J, et al. The predictive values of beta1-adrenergic and M2 muscarinic receptor autoantibodies for sudden cardiac death in patients with chronic heart failure. Eur J Heart Fail. 2012;14(8):887-894. doi:10.1093/eurjhf/hfs082
196. Perrin, M. H., & Vale, W. W. (1999). Corticotropin releasing factor receptors and their ligand family. Annals of the New York Academy of Sciences, 885(1), 312-328.
197. Pisarenko, O. I., Shulzhenko, V. S., & Studneva, I. M. (1999). Metabolic and functional effects of carbachol and ischaemic preconditioning in rat isolated heart. Clinical and experimental pharmacology & physiology, 26(1), 26–31. https://doi.org/10.1046/j.1440-1681.1999.02982.x
198. Pönicke, K., Heinroth-Hoffmann, I., & Brodde, O. E. (2003). Demonstration of functional M3-muscarinic receptors in ventricular cardiomyocytes of adult rats. British journal of pharmacology, 138(1), 156–160. https://doi.org/10.1038/sj.bjp.0704997
199. Porges S. W. (1992). Vagal tone: a physiologic marker of stress vulnerability. Pediatrics, 90(3 Pt 2), 498–504.
200. Prithika, U., Vikneswari, R., & Balamurugan, K. (2017). Short term memory of Caenorhabditis elegans against bacterial pathogens involves CREB transcription factor. Immunobiology, 222(4), 684–692. https://doi.org/10.1016/j.imbio.2016.12.008
201. Quaedflieg, C., & Schwabe, L. (2018). Memory dynamics under stress. Memory (Hove, England), 26(3), 364–376.https://doi.org/10.1080/09658211.2017.1338299
202. Racké, K., Juergens, U. R., & Matthiesen, S. (2006). Control by cholinergic mechanisms. European journal of pharmacology, 533(1-3), 57–68. https://doi.org/10.1016/j.ejphar.2005.12.050
203. Randáková, A., Nelic, D., Ungerová, D., Nwokoye, P., Su, Q., Doležal, V., El-Fakahany, E. E., Boulos, J., & Jakubík, J. (2020). Novel M2 -selective, Gi -biased agonists of muscarinic acetylcholine receptors. British journal of pharmacology, 177(9), 2073–2089. https://doi.org/10.1111/bph.14970
204. Randall, D. C., Brown, D. R., McGuirt, A. S., Thompson, G. W., Armour, J. A., & Ardell, J. L. (2003). Interactions within the intrinsic cardiac nervous system contribute to chronotropic regulation. American journal of physiology. Regulatory, integrative and comparative physiology, 285(5), R1066–R1075.https://doi.org/10.1152/ajpregu.00167.2003
205. Rauchenzauner, M., Ernst, F., Hintringer, F., Ulmer, H., Ebenbichler, C. F., Kasseroler, M. T., & Joannidis, M. (2009). Arrhythmias and increased neuro-endocrine stress response during physicians' night shifts: a randomized cross-over trial. European heart journal, 30(21), 2606–2613. https://doi.org/10.1093/eurheartj/ehp268
206. Refojo, D., Schweizer, M., Kuehne, C., Ehrenberg, S., Thoeringer, C., Vogl, A. M., ... & Deussing, J. M. (2011). Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1. Science, 333(6051), 1903-1907.
207. Rohrer, D. K., Desai, K. H., Jasper, J. R., Stevens, M. E., Regula, D. P., Jr, Barsh, G. S., Bernstein, D., & Kobilka, B. K. (1996). Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects. Proceedings of the National Academy of Sciences of the United States of America, 93(14), 7375–7380. https://doi.org/10.1073/pnas.93.14.7375
208. Rom, O., & Reznick, A. Z. (2016). The Stress Reaction: A Historical Perspective. Advances in experimental medicine and biology, 905, 1–4.https://doi.org/10.1007/5584_2015_195
209. Romero, L. M., Dickens, M. J., & Cyr, N. E. (2009). The Reactive Scope Model - a new model integrating homeostasis, allostasis, and stress. Hormones and behavior, 55(3), 375–389. https://doi.org/10.1016/j.yhbeh.2008.12.009
210. Sabban, E. L., Schilt, N., Serova, L. I., Masineni, S. N., & Stier, C. T., Jr (2009). Kinetics and persistence of cardiovascular and locomotor effects of immobilization stress and influence of ACTH treatment. Neuroendocrinology, 89(1), 98–108.https://doi.org/10.1159/000150099
211. Saeed Rubina W., Santosh Varma, Tina Peng-Nemeroff, Barbara Sherry, David Balakhaneh, Jared Huston, Kevin J. Tracey, Yousef Al-Abed, Christine N. Metz; Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation . J Exp Med 4 April 2005; 201 (7): 1113–1123. doi: https://doi.org/10.1084/jem.20040463
212. Sand, C., Peters, S. L., Pfaffendorf, M., & van Zwieten, P. A. (2003). Effects of hypochlorite and hydrogen peroxide on cardiac autonomic receptors and vascular endothelial function. Clinical and experimental pharmacology & physiology, 30(4), 249–253.https://doi.org/10.1046/j.1440-1681.2003.03822.x
213. Santos IN, Spadari-Bratfisch RC. Stress and cardiac beta adrenoceptors. Stress. 2006 Jun;9(2):69-84. doi: 10.1080/10253890600771858. PMID: 16895831.
214. Sassone-Corsi P. (1998). Coupling gene expression to cAMP signalling: role of CREB and CREM. The international journal of biochemistry & cell biology, 30(1), 27–38. https://doi.org/10.1016/s1357-2725(97)00093-9
215. Sauvage, M., & Steckler, T. (2001). Detection of corticotropin-releasing hormone receptor 1 immunoreactivity in cholinergic, dopaminergic and noradrenergic neurons of the murine basal forebrain and brainstem nuclei--potential implication for arousal and attention. Neuroscience, 104(3), 643–652.https://doi.org/10.1016/s0306-4522(01)00137-3
216. Schaaf, M. J., De Kloet, E. R., & Vreugdenhil, E. (2000). Corticosterone effects on BDNF expression in the hippocampus. Implications for memory formation. Stress (Amsterdam, Netherlands), 3(3), 201–208. https://doi.org/10.3109/10253890009001124
217. Schrader, H., Bovim, G., & Sand, T. (1993). The prevalence of delayed and advanced sleep phase syndromes. Journal of sleep research, 2(1), 51–55.https://doi.org/10.1111/j.1365-2869.1993.tb00061.x
218. Schroeder, A. M., & Colwell, C. S. (2013). How to fix a broken clock. Trends in pharmacological sciences, 34(11), 605–619. https://doi.org/10.1016/j.tips.2013.09.002
219. Schulkin J. (2003). Allostasis: a neural behavioral perspective. Hormones and behavior, 43(1), 21–30. https://doi.org/10.1016/s0018-506x(02)00035-1
220. Schulkin, J., & Sterling, P. (2019). Allostasis: A Brain-Centered, Predictive Mode of Physiological Regulation. Trends in neurosciences, 42(10), 740–752.https://doi.org/10.1016/j.tins.2019.07.010
221. Seeger, T., Fedorova, I., Zheng, F., Miyakawa, T., Koustova, E., Gomeza, J., Basile, A. S., Alzheimer, C., & Wess, J. (2004). M2 muscarinic acetylcholine receptor knock-out mice show deficits in behavioral flexibility, working memory, and hippocampal plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(45), 10117–10127. https://doi.org/10.1523/JNEUROSCI.3581-04.2004
222. Selye H. (1975). Confusion and controversy in the stress field. Journal of human stress, 1(2), 37–44. https://doi.org/10.1080/0097840X.1975.9940406
223. Selye, H. A Syndrome produced by Diverse Nocuous Agents. Nature 138, 32 (1936). https://doi.org/10.1038/138032a0
224. Selye H. (1950). Stress and the general adaptation syndrome. British medical journal, 1(4667), 1383–1392. https://doi.org/10.1136/bmj.1.4667.1383
225. Selye, H. (1973). Homeostasis and Heterostasis. Perspectives in Biology and Medicine 16(3), 441-445. doi:10.1353/pbm.1973.0056
226. Selye H. (1976). Stress without distress. Le stress sans detresse. Bruxelles medical, 56(5), 205–210.
227. Sen, A., Kara, A. Y., Koyu, A., Simsek, F., Kizildag, S., & Uysal, N. (2021). The effects of chronic restraint stress on empathy-like behaviour in rats. Neuroscience letters, 765, 136255. https://doi.org/10.1016/j.neulet.2021.136255
228. Sgoifo, A., Pozzato, C., Meerlo, P., Costoli, T., Manghi, M., Stilli, D., Olivetti, G., & Musso, E. (2002). Intermittent exposure to social defeat and open-field test in rats: acute and long-term effects on ECG, body temperature and physical activity. Stress (Amsterdam, Netherlands), 5(1), 23–35.https://doi.org/10.1080/102538902900012387
229. Shavit Stein, E., Itsekson Hayosh, Z., Vlachos, A., & Maggio, N. (2017). Stress and Corticosteroids Modulate Muscarinic Long Term Potentiation (mLTP) in the Hippocampus. Frontiers in cellular neuroscience, 11, 299. https://doi.org/10.3389/fncel.2017.00299
230. Shaw, E., & Tofler, G. H. (2009). Circadian rhythm and cardiovascular disease. Current atherosclerosis reports, 11(4), 289–295.https://doi.org/10.1007/s11883-009-0044-4
231. Sherman, J. E., & Kalin, N. H. (1987). The effects of ICV-CRH on novelty-induced behavior. Pharmacology, biochemistry, and behavior, 26(4), 699–703. https://doi.org/10.1016/0091-3057(87)90599-5
232. Sikora, M., Konopelski, P., Pham, K., Wyczalkowska-Tomasik, A., & Ufnal, M. (2016). Repeated restraint stress produces acute and chronic changes in hemodynamic parameters in rats. Stress (Amsterdam, Netherlands), 19(6), 621–629. https://doi.org/10.1080/10253890.2016.1244667
233. Skeberdis V. A. (2004). Structure and function of beta3-adrenergic receptors. Medicina (Kaunas, Lithuania), 40(5), 407–413.
234. Skeberdis, V. A., Gendviliene, V., Zablockaite, D., Treinys, R., Macianskiene, R., Bogdelis, A., Jurevicius, J., & Fischmeister, R. (2008). beta3-adrenergic receptor activation increases human atrial tissue contractility and stimulates the L-type Ca2+ current. The Journal of clinical investigation, 118(9), 3219–3227. https://doi.org/10.1172/JCI32519
235. Smagin, G. N., Heinrichs, S. C., & Dunn, A. J. (2001). The role of CRH in behavioral responses to stress. Peptides, 22(5), 713–724.https://doi.org/10.1016/s0196-9781(01)00384-9
236. Smith, M. A., Makino, S., Kvetnansky, R., & Post, R. M. (1995). Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 15(3 Pt 1), 1768–1777. https://doi.org/10.1523/JNEUROSCI.15-03-01768.1995
237. Snyder, K. P., Hill-Smith, T. E., Lucki, I., & Valentino, R. J. (2015). Corticotropin-releasing Factor in the Rat Dorsal Raphe Nucleus Promotes Different Forms of Behavioral Flexibility Depending on Social Stress History. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(11), 2517–2525. https://doi.org/10.1038/npp.2015.98
238. Sohn J. W. (2015). Network of hypothalamic neurons that control appetite. BMB reports, 48(4), 229–233. https://doi.org/10.5483/bmbrep.2015.48.4.272
239. Souza, G. G., Mendonça-de-Souza, A. C., Barros, E. M., Coutinho, E. F., Oliveira, L., Mendlowicz, M. V., Figueira, I., & Volchan, E. (2007). Resilience and vagal tone predict cardiac recovery from acute social stress. Stress (Amsterdam, Netherlands), 10(4), 368–374. https://doi.org/10.1080/10253890701419886
240. Spani, D., Arras, M., König, B., & Rülicke, T. (2003). Higher heart rate of laboratory mice housed individually vs in pairs. Laboratory animals, 37(1), 54–62.https://doi.org/10.1258/002367703762226692
241. Stengel, P. W., Gomeza, J., Wess, J., & Cohen, M. L. (2000). M(2) and M(4) receptor knockout mice: muscarinic receptor function in cardiac and smooth muscle in vitro. The Journal of pharmacology and experimental therapeutics, 292(3), 877–885.
242. Sterling, P., & Eyer, J. (1988). Allostasis: A new paradigm to explain arousal pathology. In S. Fisher, & J. Reason (Eds.), Handbook of life stress, cognition and health (pp. 629-649). New York: John Wiley & Sons.
243. Sun, L., Li, D. L., Zhao, M., He, X., Yu, X. J., Miao, Y., Wang, H., Ren, J., & Zang, W. J. (2011). The role of muscarinic receptors in the beneficial effects of adenosine against myocardial reperfusion injury in rats. PloS one, 6(11), e25618.https://doi.org/10.1371/journal.pone.0025618
244. Swaab, D. F., Bao, A. M., & Lucassen, P. J. (2005). The stress system in the human brain in depression and neurodegeneration. Ageing research reviews, 4(2), 141–194.https://doi.org/10.1016/j.arr.2005.03.003
245. Swoap, S. J., Li, C., Wess, J., Parsons, A. D., Williams, T. D., & Overton, J. M. (2008). Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality. American journal of physiology. Heart and circulatory physiology, 294(4), H1581–H1588. https://doi.org/10.1152/ajpheart.01000.2007
246. Szczepanska-Sadowska, E., Wsol, A., Cudnoch-Jedrzejewska, A., & Żera, T. (2021). Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation. International journal of molecular sciences, 22(21), 11465. https://doi.org/10.3390/ijms222111465
247. Takahashi J. S. (2017). Transcriptional architecture of the mammalian circadian clock. Nature reviews. Genetics, 18(3), 164–179. https://doi.org/10.1038/nrg.2016.150
248. Takeuchi, H., Enzo, A., & Minamitani, H. (2001). Circadian rhythm changes in heart rate variability during chronic sound stress. Medical & biological engineering & computing, 39(1), 113–117. https://doi.org/10.1007/BF02345274
249. Thakur, T., Anand, R., Ray, A., & Gulati, K. (2015). Differential effects of chronic predictable and unpredictable stress on neurobehavioral and biochemical responses in rats. Therapeutic Targets for Neurological Diseases, 2.
250. Thompson, R. S., Christianson, J. P., Maslanik, T. M., Maier, S. F., Greenwood, B. N., & Fleshner, M. (2013). Effects of stressor controllability on diurnal physiological rhythms. Physiology & behavior, 112-113, 32–39.https://doi.org/10.1016/j.physbeh.2013.02.009
251. Thosar, S. S., Butler, M. P., & Shea, S. A. (2018). Role of the circadian system in cardiovascular disease. The Journal of clinical investigation, 128(6), 2157–2167. https://doi.org/10.1172/JCI80590
252. Tillinger, A., Novakova, M., Krizanova, O., Kvetnansky, R., & Myslivecek, J. (2014). Heart ventricles specific stress-induced changes in β-adrenoceptors and muscarinic receptors. General physiology and biophysics, 33(3), 357–364. https://doi.org/10.4149/gpb_2014002
253. Tomankova, H., & Myslivecek, J. (2011). Mechanisms of G protein-coupled receptors regulation. Neuro endocrinology letters, 32(5), 607–615.
254. Tornatzky, W., & Miczek, K. A. (1993). Long-term impairment of autonomic circadian rhythms after brief intermittent social stress. Physiology & behavior, 53(5), 983–993. https://doi.org/10.1016/0031-9384(93)90278-n
255. Trendelenburg, A. U., Meyer, A., Wess, J., & Starke, K. (2005). Distinct mixtures of muscarinic receptor subtypes mediate inhibition of noradrenaline release in different mouse peripheral tissues, as studied with receptor knockout mice. British journal of pharmacology, 145(8), 1153–1159. https://doi.org/10.1038/sj.bjp.0706297
256. Tsigos, C., & Chrousos, G. P. (2002). Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. Journal of psychosomatic research, 53(4), 865–871. https://doi.org/10.1016/s0022-3999(02)00429-4
257. Tsukamura H. (2022). Kobayashi Award 2019: The neuroendocrine regulation of the mammalian reproduction. General and comparative endocrinology, 315, 113755.https://doi.org/10.1016/j.ygcen.2021.113755
258. Valentino, R. J., Liouterman, L., & Van Bockstaele, E. J. (2001). Evidence for regional heterogeneity in corticotropin-releasing factor interactions in the dorsal raphe nucleus. The Journal of comparative neurology, 435(4), 450–463.https://doi.org/10.1002/cne.1043
259. Valuskova, P., Farar, V., Janisova, K., Ondicova, K., Mravec, B., Kvetnansky, R., & Myslivecek, J. (2017). Brain region-specific effects of immobilization stress on cholinesterases in mice. Stress (Amsterdam, Netherlands), 20(1), 36–43. https://doi.org/10.1080/10253890.2016.1263836
260. Venihaki, M., & Majzoub, J. (2002). Lessons from CRH knockout mice. Neuropeptides, 36(2-3), 96–102.https://doi.org/10.1054/npep.2002.0906
261. Vosko, A. M., Colwell, C. S., & Avidan, A. Y. (2010). Jet lag syndrome: circadian organization, pathophysiology, and management strategies. Nature and science of sleep, 2, 187–198. https://doi.org/10.2147/NSS.S6683
262. Wang, Z., Shi, H., & Wang, H. (2004). Functional M3 muscarinic acetylcholine receptors in mammalian hearts. British journal of pharmacology, 142(3), 395–408. https://doi.org/10.1038/sj.bjp.0705787
263. Wang, H., Lu, Y., & Wang, Z. (2007). Function of cardiac M3 receptors. Autonomic & autacoid pharmacology, 27(1), 1–11.https://doi.org/10.1111/j.1474-8673.2006.00381.x
264. Wang, X. D., Rammes, G., Kraev, I., Wolf, M., Liebl, C., Scharf, S. H., Rice, C. J., Wurst, W., Holsboer, F., Deussing, J. M., Baram, T. Z., Stewart, M. G., Müller, M. B., & Schmidt, M. V. (2011). Forebrain CRF₁ modulates early-life stress-programmed cognitive deficits. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(38), 13625–13634. https://doi.org/10.1523/JNEUROSCI.2259-11.201
265. Wallukat, G., Nissen, E., Morwinski, R., & Müller, J. (2000). Autoantibodies against the beta- and muscarinic receptors in cardiomyopathy. Herz, 25(3), 261–266. https://doi.org/10.1007/s000590050017
266. Weil, Z. M., Norman, G. J., DeVries, A. C., Berntson, G. G., & Nelson, R. J. (2009). Photoperiod alters autonomic regulation of the heart. Proceedings of the National Academy of Sciences of the United States of America, 106(11), 4525–4530.https://doi.org/10.1073/pnas.0810973106
267. Weinstock M. (2010). Intrauterine factors as determinants of depressive disorder. The Israel journal of psychiatry and related sciences, 47(1), 36–45.
268. Weiss, S., Keren-Raifman, T., Oz, S., Ben Mocha, A., Haase, H., & Dascal, N. (2012). Modulation of distinct isoforms of L-type calcium channels by G(q)-coupled receptors in Xenopus oocytes: antagonistic effects of Gβγ and protein kinase C. Channels (Austin, Tex.), 6(6), 426–437. https://doi.org/10.4161/chan.22016
269. Wess, J., Duttaroy, A., Zhang, W., Gomeza, J., Cui, Y., Miyakawa, T., Bymaster, F. P., McKinzie, L., Felder, C. C., Lamping, K. G., Faraci, F. M., Deng, C., & Yamada, M. (2003). M1-M5 muscarinic receptor knockout mice as novel tools to study the physiological roles of the muscarinic cholinergic system. Receptors & channels, 9(4), 279–290.
270. Werry, T. D., Wilkinson, G. F., & Willars, G. B. (2003). Mechanisms of cross-talk between G-protein-coupled receptors resulting in enhanced release of intracellular Ca2+. The Biochemical journal, 374(Pt 2), 281–296.https://doi.org/10.1042/BJ20030312
271. Willmy-Matthes P, Leineweber K, Wangemann T, Silber RE, Brodde OE. Existence of functional M3-muscarinic receptors in the human heart. Naunyn Schmiedebergs Arch Pharmacol. 2003 Oct;368(4):316-9. doi: 10.1007/s00210-003-0796-2. Epub 2003 Oct 1. PMID: 14520506.
272. Winter, J., Jurek, B. The interplay between oxytocin and the CRF system: regulation of the stress response. Cell Tissue Res 375, 85–91 (2019). https://doi.org/10.1007/s00441-018-2866-2
273. Witte, K., Parsa-Parsi, R., Vobig, M., & Lemmer, B. (1995). Mechanisms of the circadian regulation of beta-adrenoceptor density and adenylyl cyclase activity in cardiac tissue from normotensive and spontaneously hypertensive rats. Journal of molecular and cellular cardiology, 27(5), 1195–1202. https://doi.org/10.1016/0022-2828(95)90055-1
274. Witte, K., Engelhardt, S., Janssen, B. J., Lohse, M., & Lemmer, B. (2004). Circadian and short-term regulation of blood pressure and heart rate in transgenic mice with cardiac overexpression of the beta1-adrenoceptor. Chronobiology international, 21(2), 205–216.https://doi.org/10.1081/cbi-120037801
275. Yaniv, Y., Lakatta, E. G., & Maltsev, V. A. (2015). From two competing oscillators to one coupled-clock pacemaker cell system. Frontiers in physiology, 6, 28. https://doi.org/10.3389/fphys.2015.00028
276. Yoshimura, N., Sasa, M., Yoshida, O., & Takaori, S. (1990). Alpha 1-adrenergic receptor-mediated excitation from the locus coeruleus of the sacral parasympathetic preganglionic neuron. Life sciences, 47(9), 789–797. https://doi.org/10.1016/0024-3205(90)90551-2
277. Zaglia, T., & Mongillo, M. (2017). Cardiac sympathetic innervation, from a different point of (re)view. The Journal of physiology, 595(12), 3919–3930. https://doi.org/10.1113/JP273120
278. Zasadny, F. M., Dyavanapalli, J., Dowling, N. M., Mendelowitz, D., & Kay, M. W. (2020). Cholinergic stimulation improves electrophysiological rate adaptation during pressure overload-induced heart failure in rats. American journal of physiology. Heart and circulatory physiology, 319(6), H1358–H1368. Advance online publication. https://doi.org/10.1152/ajpheart.00293.2020
279. Zeng, Y., Brydges, N. M., Wood, E. R., Drake, A. J., & Hall, J. (2015). Prenatal glucocorticoid exposure in rats: programming effects on stress reactivity and cognition in adult offspring. Stress, 18(3), 353-361.
280. Zhang, J., Fan, Y., Li, Y., Zhu, H., Wang, L., & Zhu, M. Y. (2012). Chronic social defeat up-regulates expression of the serotonin transporter in rat dorsal raphe nukleus and projection regions in a glucocorticoid-dependent manner. Journal of neurochemistry, 123(6), 1054–1068. https://doi.org/10.1111/jnc.12055
281. Zhao, Z. D., Yang, W. Z., Gao, C., Fu, X., Zhang, W., Zhou, Q., Chen, W., Ni, X., Lin, J. K., Yang, J., Xu, X. H., & Shen, W. L. (2017). A hypothalamic circuit that controls body temperature. Proceedings of the National Academy of Sciences of the United States of America, 114(8), 2042–2047.https://doi.org/10.1073/pnas.1616255114
282. Zheng, F., Wess, J., & Alzheimer, C. (2012). M2 muscarinic acetylcholine receptors regulate long-term potentiation at hippocampal CA3 pyramidal cell synapses in an input-specific fashion. Journal of neurophysiology, 108(1), 91–100. https://doi.org/10.1152/jn.00740.2011
283. Zhou, H., Meyer, A., Starke, K., Gomeza, J., Wess, J., & Trendelenburg, A. U. (2002). Heterogeneity of release-inhibiting muscarinic autoreceptors in heart atria and urinary bladder: a study with M(2)- and M(4)-receptor-deficient mice. Naunyn-Schmiedeberg's archives of pharmacology, 365(2), 112–122.https://doi.org/10.1007/s00210-001-0517-7
284. Zimprich, A., Garrett, L., Deussing, J. M., Wotjak, C. T., Fuchs, H., Gailus-Durner, V., de Angelis, M. H., Wurst, W., & Hölter, S. M. (2014). A robust and reliable non-invasive test for stress responsivity in mice. Frontiers in behavioral neuroscience, 8, 125. https://doi.org/10.3389/fnbeh.2014.00125
285. Zylbergold, P., Ramakrishnan, N., & Hebert, T. (2010). The role of G proteins in assembly and function of Kir3 inwardly rectifying potassium channels. Channels (Austin, Tex.), 4(5), 411–421.https://doi.org/10.4161/chan.4.5.13327
Předběžná náplň práce
Tato práce si klade za cíl analyzovat roli muskarinových M2 receptorů (M2MR) v organismu v situaci klidového stavu a ve stresu. Základní funkcí těchto receptorů na periferii je regulace srdeční frekvence, proto lze sledováním změn v srdeční frekvenci hodnotit aktivitu M2MR. V experimentech jsou sledovány změny u subjektů s exprimovanými M2MR a porovnávány s jedinci M2KO, kterým tyto receptory chybí. Srdeční frekvence je funkcí vztahu mezi sympatickým a parasympatickým autonomním tonem; výsledná frekvence je tedy určena interakcí adrenergních a cholinergních receptorů, které jsou spřaženy s G proteiny. Jejich aktivita je ovlivňována etážemi autonomního nervového systému (ANS) s nejvyššími kontrolními centry v hypothalamu, který funguje jako integrátor. Organismus reaguje na absenci M2MR snížením počtu adrenergních receptorů, srdeční frekvence v klidových podmínkách se výrazně nemění. Při stresu omezením volného pohybu (restraint stres) však dochází k rozdílům jak v průběhu stresové reakce, tak v postresovém období, kdy se projeví nedostatek kardioinhibičního vlivu parasympatického nervového systému. Předpokládalo se, že SF určuje vztah mezi adrenergními β (kardioexcitační) a cholinergními M2 (kardioinhibiční) receptory, ale u jedinců s M2KO se může projevit vliv nonM2MR po podání karbacholu (muskarinový agonista).
Ultradiánní srdeční rytmus je nadstavbou cirkadiánního rytmu, kde jsou struktury hypothalamu, konkrétně suprachiasmatické jádro (SCN), určujícím pacemakerem. Odpověď ANS může ovlivnit další hypotalamické funkce – cirkadiánní rytmus, endokrinní regulaci, metabolismus, termoregulaci, příjem potravy a tekutin a může evokovat změny chování a mít vliv na paměť. Proto předpokládáme, že stres by mohl ovlivnit i výše uvedené procesy. Součástí stresové odpovědi je i sekrece kortikotropin releasing hormonu (CRH), má vliv endokrinní na hypotalamo-hypofyzární osu (HPA) a nonHPA účinek jako neuromediátor. Zkoumali jsme vliv stresu na chování a krátkodobou paměť, vliv na dlouhodobou paměť je známý.
Princip dlouhodobé trvalé sympatické stimulace a snížení parasympatického tonu je známý při chronickém srdečním selhání, obstrukční spánkové apnoe nebo dlouhodobé katecholaminové terapii, což je patologická situace, kterou může stres akcentovat. Aferentní informace do hypotalamických center ovlivní celou řadu integračních funkcí hypothalamu (emoce, metabolismus, humorální regulace).
Předběžná náplň práce v anglickém jazyce
This work aims to analyze the role of muscarinic M2 receptors in an organism in the situation of resting state and stress. The core function of these receptors on the periphery is heart rate regulation, therefore, by monitoring the changes in heart rate M2 muscarinic receptor activity can be assessed. In the experiments monitored changes in subjects with expressed M2 muscarinic receptors are compared with M2KO subjects who lack these receptors. Heart rate is the function of the relationship between sympathetic tone and parasympathetic tone; thus, the resulting frequency is determined by the interaction of adrenergic and cholinergic receptors, either of which is attached to the G proteins. Their activity is influenced by the autonomic nervous system network levels with the highest controlling centres in the hypothalamus, which serves as an integrator. The organism responds to the absence of M2 muscarinic receptors by decreasing the number of adrenergic receptors, the heart rate in resting conditions does not change significantly. However, when stressed by restraint of free movement (restraint stress), there are differences both during the stress response and in the post-stress period when a lack of the counteracting influence of the parasympathetic nervous system becomes apparent. The relationship was also thought to be within adrenergic and cholinergic receptors, with M2KO subjects showing evidence of nonM2MR after administration of carbachol (muscarinic agonist).
Ultradian heart rate rhythm is superimposed to circadian rhythm, where hypothalamus structures, specifically the suprachiasmatic nucleus (SCN), are the defining pacemaker. The autonomic response may modify other hypothalamic functions - circadian rhythms, endocrine regulation, metabolism, thermoregulation, food, and fluid intake, and may evoke behavioural changes and have an influence on memory. Therefore, we assume that stress could also impact the above processes. Corticotropin-releasing hormone (CRH) is secreted as a part of the stress response, it works within endocrine system (hypothalamo-hypophyseal or HPA axis effect) and acts as a neuromediator (nonHPA effect). In subjects lacking CRH, we investigate the effect of restraint stress on behaviour and short-term memory, the impact on long-term memory trace has been known.
The principle of long-term sustained sympathetic stimulation and reduction of parasympathetic nervous system tone is known in chronic heart failure, obstructive sleep apnoea, or long-term catecholamine therapy, a situation that can be accentuated by stress. The afferent information to hypothalamic centres will affect a variety of integrative functions of the hypothalamus (emotions, metabolism, humoral regulation).
 
Univerzita Karlova | Informační systém UK