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Výsledky projektu Solubilní endoglin jako rizikovy faktor estrogeny-indukované cholestázy?

Výsledky

▼▲Typ výsledku ▼▲Autor celku ▼▲Název celku
(Celkem 11 zázn.)
Dolezelova, Eva; Igreja Sa, Ivone Cristina; Prasnicka, Alena; Hroch, Milos; Hyspler, Radomir; Ticha, Alena; Lastuvkova, Hana; Cermanova, Jolana; Pericacho, Miguel; Visek, Jakub; Lasticova, Martina; Micuda, Stanislav; Nachtigal, Petr.. High soluble endoglin levels regulate cholesterol homeostasis and bile acids turnover in the liver of transgenic mice. Life Sciences, 2019, sv. 232, s. 1–13. ISSN 0024-3205. IF 3.647. [Článek v časopise]
Article number 116643. https://doi.org/10.1016/j.lfs.2019.116643.

For the first time, we have shown that high sEng plasma levels affect BA homeostasis on the basis of complex liver and intestinal effects. These results from healthy male mice show that high sEng modulates BA metabolism by increasing systemic plasma concentrations of BA due to their increased reabsorption in the ileum, as well as inducing synthesis of BA and promoting their biliary excretion.
Igreja Sá, Ivone Cristina; Tripska, Katarina; Hroch, Milos; Hyspler, Radomir; Ticha, Alena; Lastuvkova, Hana; Schreiberova, Jolana; Dolezelova, Eva; Eissazadeh, Samira; Vitverova, Barbora; Najmanova, Iveta; Vasinova, Martina; Pericacho, Miguel; Micuda, Stanislav; Nachtigal, Petr.. Soluble endoglin as a potential biomarker of nonalcoholic steatohepatitis (NASH) development, participating in aggravation of NASH-related changes in mouse liver. International Journal of Molecular Sciences, 2020, sv. 21(23), s. 1–19. ISSN 1422-0067. IF 6.496. [Článek v časopise]
Article number: 9021. https://doi.org/10.3390/ijms21239021
Igreja Sá, Ivone, Oral presentation at the 25th Congress on Atherosclerosis in Prague [Jiný výsledek]
Igreja Sá, Ivone, ePoster presentation at EAS Congress 2021: A Virtual Congress [Jiný výsledek]
Igreja Sá, Ivone, Unpublished manuscript "Soluble endoglin as a risk factor of estrogen-induced cholestasis" [Jiný výsledek]
Igreja Sá, Ivone, Soluble endoglin as a risk factor of estrogen-induced cholestasis? – 3rd. Year [Jiný výsledek]
Igreja Sá, Ivone, Abstract for oral presentation at 12th Postgraduate and Postdoc Conference at the Faculty of Pharmacy in Hradec Králové, Charles University [Jiný výsledek]
Igreja Sá, Ivone, Poster presentation at EAS 2020 online conference [Jiný výsledek]
Igreja Sá, Ivone, Soluble endoglin as a risk factor of estrogen-induced cholestasis? – 2nd. Year [Jiný výsledek]
Igreja Sá, Ivone, Soluble endoglin as a risk factor of estrogen-induced cholestasis? – 1. Year [Jiný výsledek]
Igreja Sá, Ivone, Poster 23rd Congress on Atherosclerosis in Pilsen [Jiný výsledek]